concept

MEF2 TARGET GENES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MEF2 TARGET GENES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

24Connections

0Hypotheses

1Analyses

9Outgoing

15Incoming

0Experiments

1Debates

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💡 Concept Info

Name	MEF2 TARGET GENES
Key Genes/Proteins	AKT, AND, GENES, HDAC, HDAC4, HDAC7
Related Diseases	ALS, Tumor
Related Pathways	Pi3K/Akt

Pathway Diagram

graph TD
    MEF2_TARGET_GENES["MEF2 TARGET GENES"]
    MEF2_TARGET_GENES -->|"inhibits"| PI3K["PI3K"]
    MEF2_TARGET_GENES -->|"inhibits"| Pi3K_Akt["Pi3K/Akt"]
    MEF2_TARGET_GENES -->|"inhibits"| HDAC["HDAC"]
    MEF2_TARGET_GENES -->|"inhibits"| AND["AND"]
    MEF2_TARGET_GENES -->|"inhibits"| GENES["GENES"]
    HDAC4["HDAC4"] -->|"downregulates"| MEF2_TARGET_GENES
    PI3K -->|"regulates"| MEF2_TARGET_GENES
    GENES -->|"inhibits"| MEF2_TARGET_GENES
    AKT["AKT"] -->|"inhibits"| MEF2_TARGET_GENES
    HDAC -->|"inhibits"| MEF2_TARGET_GENES
    AND -->|"inhibits"| MEF2_TARGET_GENES

Outgoing (9)

Target	Relation	Type	Str
Tumor	associated_with	disease	0.65
ALS	associated_with	disease	0.65
HDAC7	associated_with	gene	0.60
PI3K	inhibits	gene	0.60
Pi3K/Akt	inhibits	pathway	0.60
AND	inhibits	gene	0.60
HDAC4	associated_with	gene	0.60
HDAC	inhibits	gene	0.60
GENES	inhibits	gene	0.60

Incoming (15)

Source	Relation	Type	Str
HDAC4	downregulates	protein	0.95
19109909	have diverse functions at	paper	0.90
HDAC4	downregulates	protein	0.90
19109909	are mutated in	paper	0.90
HDAC9 knockout	associated_with	gene	0.90
HDAC9 knockout	increases_expression	process	0.70
HDAC9 knockout	activates	process	0.70
HDAC9	represses	protein	0.70
HDAC4	associated_with	gene	0.60
GENES	inhibits	gene	0.60
AKT	inhibits	gene	0.60
HDAC	inhibits	gene	0.60
PTEN	associated_with	gene	0.60
HDAC7	associated_with	gene	0.60
PI3K	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

neurodegeneration | 2026-04-14 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract shows HDAC9 overexpression reduces Aβ deposition and improves synap

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

Related Research

Hypotheses and analyses mentioning MEF2 TARGET GENES in their description or question text

No additional research found