HDAC4

Understanding Entity Pages

This page aggregates everything SciDEX knows about HDAC4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

HDAC4 is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, therapeutic target. Associated with ALS, Aging, Als. Connected to 50 entities in the SciDEX knowledge graph.

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graph TD
    HDAC4["<b>HDAC4</b>"]
    Senescence{"Senescence"}
    HDAC4 -->|"therapeutic target"| Senescence
    Aging{"Aging"}
    HDAC4 -->|"inhibits"| Aging
    Ms{"Ms"}
    HDAC4 -->|"inhibits"| Ms
    Cardiovascular{"Cardiovascular"}
    HDAC4 -->|"therapeutic target"| Cardiovascular
    Tumor{"Tumor"}
    HDAC4 -->|"therapeutic target"| Tumor
    Als{"Als"}
    HDAC4 -->|"therapeutic target"| Als
    HDAC4 -->|"associated with"| Aging
    HDAC4 -->|"inhibits"| Senescence
    HDAC4 -->|"inhibits"| Cardiovascular
    HDAC4 -->|"associated with"| Tumor
    ALS{"ALS"}
    HDAC4 -->|"associated with"| ALS
    MEF2A["MEF2A"]
    HDAC4 -->|"inhibits"| MEF2A
    HDAC7["HDAC7"]
    HDAC7 -->|"associated with"| HDAC4
    PTEN["PTEN"]
    PTEN -->|"associated with"| HDAC4
    MEF2A -->|"inhibits"| HDAC4
    DNA["DNA"]
    DNA -->|"inhibits"| HDAC4
    PI3K["PI3K"]
    PI3K -->|"therapeutic target"| HDAC4
    GENES["GENES"]
    GENES -->|"therapeutic target"| HDAC4
    AMPK["AMPK"]
    AMPK -->|"associated with"| HDAC4
    AQP1["AQP1"]
    AQP1 -->|"inhibits"| HDAC4
    AKT["AKT"]
    AKT -->|"therapeutic target"| HDAC4
    PI3K -->|"associated with"| HDAC4
    AND["AND"]
    AND -->|"inhibits"| HDAC4
    AGING["AGING"]
    AGING -->|"inhibits"| HDAC4
    style HDAC4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0