Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Pi3K/Akt: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Pi3K/Akt is a biological pathway involved in neurodegeneration research. Key relationships include: activates, therapeutic target, inhibits. Associated with ALS, Aging, Als. Connected to 960 entities in the SciDEX knowledge graph.
| Name | Pi3K/Akt |
| Key Genes/Proteins | PI3K, AKT, HIF, CANCER, MTOR, PTEN |
| Related Diseases | Tumor, Cancer |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
PI3K["PI3K"] -->|"activates"| Pi3K_Akt["Pi3K/Akt"]
AKT["AKT"] -->|"activates"| Pi3K_Akt["Pi3K/Akt"]
MYC["MYC"] -->|"activates"| Pi3K_Akt["Pi3K/Akt"]
HIF["HIF"] -->|"activates"| Pi3K_Akt["Pi3K/Akt"]
style Pi3K_Akt fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cellular Survival | regulates | process | 0.90 |
| Proteostasis | regulates | process | 0.90 |
| Apoptosis | inhibits | process | 0.88 |
| Neuronal Survival | activates | process | 0.85 |
| Lithium Neurotoxicity | involved_in | process | 0.85 |
| Homeostasis | associated_with | process | 0.85 |
| PI3K/AKT PATHWAY | associated_with | concept | 0.50 |
| GLUCOSE METABOLISM | associated_with | concept | 0.50 |
| PI3K/AKT PATHWAY | activates | concept | 0.50 |
| Proteins | activates | protein | 0.50 |
| GSK3 | activates | concept | 0.50 |
| PI3K/AKT SIGNALING | activates | concept | 0.50 |
| PI3K/AKT/mTOR | activates | pathway | 0.50 |
| CELL PROLIFERATION | activates | concept | 0.50 |
| PERICYTE | interacts_with | concept | 0.50 |
| ANGPT1 | interacts_with | concept | 0.50 |
| Sepsis | interacts_with | disease | 0.50 |
| PI3K/AKT PATHWAY | interacts_with | concept | 0.50 |
| EXTRACELLULAR VESICLES | interacts_with | concept | 0.50 |
| ANGPT1 | activates | concept | 0.50 |
| ENDOTHELIAL | activates | concept | 0.50 |
| Sepsis | activates | disease | 0.50 |
| ELF3 | activates | concept | 0.50 |
| CYTOKINE | activates | concept | 0.50 |
| PI3K/AKT PATHWAY | inhibits | concept | 0.50 |
| HER2 | activates | concept | 0.50 |
| MAPK SIGNALING | regulates | concept | 0.50 |
| NEUTROPHIL | associated_with | cell_type | 0.50 |
| MAPK SIGNALING | associated_with | concept | 0.50 |
| Cognitive Impairment | activates | phenotype | 0.50 |
| Neuroprotection | activates | process | 0.50 |
| ISCHEMIC | activates | concept | 0.50 |
| ISCHEMIC STROKE | activates | concept | 0.50 |
| MTOR SIGNALING | activates | concept | 0.50 |
| Erk Signaling | activates | pathway | 0.50 |
| PI3K/AKT/mTOR | associated_with | pathway | 0.50 |
| PI3K/AKT/mTOR | regulates | pathway | 0.50 |
| CELL PROLIFERATION | regulates | concept | 0.50 |
| RAPAMYCIN | regulates | concept | 0.50 |
| RAPAMYCIN | inhibits | concept | 0.50 |
| Invasion | causes | pathway | 0.50 |
| PI3K/AKT/mTOR | causes | pathway | 0.50 |
| PI3K/AKT/mTOR | interacts_with | pathway | 0.50 |
| disease | activates | disease | 0.50 |
| INSULIN | activates | concept | 0.50 |
| INSULIN | inhibits | concept | 0.50 |
| PI3K/AKT/mTOR | inhibits | pathway | 0.50 |
| MACROPHAGES | activates | concept | 0.50 |
| QUERCETIN | activates | concept | 0.50 |
| CYTOKINE | regulates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PI3K | activates | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| HIF | activates | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| Tumor | activates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| MTOR | activates | gene | 1.00 |
| PTEN | activates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| NF-ΚB | activates | gene | 1.00 |
| PI3K | regulates | gene | 1.00 |
| NF-ΚB | regulates | gene | 1.00 |
| AKT | regulates | gene | 1.00 |
| GENES | regulates | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| PI3K | inhibits | gene | 1.00 |
| AKT | inhibits | gene | 1.00 |
| GENES | inhibits | gene | 1.00 |
| APOPTOSIS | inhibits | gene | 1.00 |
| ERK | inhibits | gene | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| NRF2 | activates | gene | 1.00 |
| Aging | activates | disease | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| DNA | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| ERK | activates | gene | 1.00 |
| MTOR | regulates | gene | 1.00 |
| Tumor | regulates | disease | 1.00 |
| NF-ΚB | inhibits | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| Inflammation | inhibits | disease | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| APOPTOSIS | regulates | gene | 1.00 |
| PI3K | therapeutic_target | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| MTOR | therapeutic_target | gene | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Als | activates | disease | 1.00 |
| CANCER | regulates | gene | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Cancer | regulates | disease | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| Als | inhibits | disease | 1.00 |
| Breast Cancer | therapeutic_target | disease | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||