Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NEUROPLASTICITY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | NEUROPLASTICITY |
| Summary | The brain's capacity to reorganize its structure, function, and connections in response to neurodegenerative disease, including adaptive and maladaptive mechanisms. |
| Key Genes/Proteins | BDNF |
| Linked Hypotheses | 2 hypotheses |
Knowledge base pages for this entity
graph TD
NEUROPLASTICITY["NEUROPLASTICITY"]
NEUROPLASTICITY -.protects against.-> Multiple_Sclerosis_Progression["Multiple Sclerosis Progression"]
NEUROPLASTICITY -->|"mediates"| Cognitive_Function["Cognitive Function"]
NEUROPLASTICITY -->|"interacts"| BDNF["BDNF"]
BDNF -->|"promotes"| NEUROPLASTICITY
psychedelics["psychedelics"] -->|"promotes"| NEUROPLASTICITY
ZZCT["ZZCT"] -->|"promotes"| NEUROPLASTICITY
aging["aging"] -->|"inhibits"| NEUROPLASTICITY| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson's Disease | associated_with | disease | 0.95 |
| Major Depressive Disorder | contributes_to | disease | 0.90 |
| Multiple Sclerosis Progression | protects_against | phenotype | 0.85 |
| Brain Recovery | promotes | phenotype | 0.85 |
| NEURODEGENERATION | protects_against | disease | 0.85 |
| Cognitive Function | mediates | phenotype | 0.80 |
| Depressive Symptoms | mediates | phenotype | 0.80 |
| cognitive reserve | contributes_to | phenotype | 0.80 |
| Cytoskeletal Proteins | regulates | protein | 0.80 |
| AGING | modulates | phenotype | 0.80 |
| BDNF | interacts_with | entity | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BDNF | activates | protein | 0.72 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Vocal Cord Neuroplasticity Stimulation | 0.498 | neurodegeneration | Digital biomarkers and AI-driven early d |
| Neuroplasticity-Enhanced Learning Hypothesis | 0.424 | methodology | Unable to extract research questions - t |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Neuron type-specific optogenetic stimulation for differential stroke recovery in [PMID:38825647] | Kim RG, Cho J, Park JY, Kim YR, Lee MC, | Exp Mol Med | 2024 | 1 |
| Optogenetic control of nerve growth. [PMID:25982506] | Park S, Koppes RA, Froriep UP, Jia X, Ac | Sci Rep | 2015 | 1 |
| Optogenetic approaches for neural tissue regeneration: A review of basic optogen [PMID:39995064] | ["Eldar D", "Albert S", "Tatyana A", "Ga | Neural regeneration research | 2026 | 0 |
| A wireless optogenetic stimulation system for long-term function evaluation of m [PMID:41027946] | ["Zhou M", "Yan B", "Yang F", "Chen C", | Nature communications | 2025 | 0 |
| Neural Circuit Mapping and Neurotherapy-Based Strategies. [PMID:40715588] | ["Marei H"] | Cellular and molecular neurobi | 2025 | 0 |
| Role of BDNF-TrkB signaling in the improvement of motor function and neuroplasti [PMID:39662631] | ["Chen Y", "Mao L", "Zhou Q", "Bai D", " | Brain research bulletin | 2025 | 0 |
| Advances in sciatic nerve regeneration: A review of contemporary techniques. [PMID:40475697] | ["Ali S", "Sun M", "Khan M", "Qiang F"] | Regenerative therapy | 2025 | 0 |
| Curcumin Improves Neurogenesis in Alzheimer's Disease Mice via the Upregulation [PMID:38791161] | Lou S, Gong D, Yang M, Qiu Q, Luo J et a | Int J Mol Sci | 2024 | 0 |
| A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic p [PMID:39205389] | Fonseca-Gomes J, Costa-Coelho T, Ferreir | Mol Ther | 2024 | 0 |
| Untitled [PMID:38753056] | ["Wang H", "Huang Z", "Lou S", "Li W", " | Chemical research in toxicolog | 2024 | 0 |
| Electrical Stimulation: How It Works and How to Apply It. [PMID:38972685] | ["Senger J", "Power H", "Moore A"] | Hand clinics | 2024 | 0 |
| Ultrasound-Triggered NO Release to Promote Axonal Regeneration for Noise-Induced [PMID:39561026] | ["Chen B", "Sun Y", "Sun H", "Cong N", " | ACS nano | 2024 | 0 |
| Efficacy of Probiotic Supplements on Brain-Derived Neurotrophic Factor, Inflamma [PMID:38201846] | Hsu YC, Huang YY, Tsai SY, Kuo YW, Lin J | Nutrients | 2023 | 0 |
| Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical [PMID:35090576] | Gao L, Zhang Y, Sterling K, Song W | Transl Neurodegener | 2022 | 0 |
| Enhancing Motor and Sensory Axon Regeneration after Peripheral Nerve Injury Usin [PMID:36555724] | ["Ecanow A", "Berglund K", "Carrasco D", | International journal of molec | 2022 | 0 |
| The impact of acupuncture on neuroplasticity after ischemic stroke: a literature [PMID:36439200] | ["Qin S", "Zhang Z", "Zhao Y", "Liu J", | Frontiers in cellular neurosci | 2022 | 0 |
| The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease. [PMID:32603820] | Amidfar M, de Oliveira J, Kucharska E, B | Life Sci | 2020 | 0 |
| Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in D [PMID:33096634] | Colucci-D'Amato L, Speranza L, Volpicell | Int J Mol Sci | 2020 | 0 |
| Co-transplantation of Schwann cells and neural stem cells in the laminin-chitosa [PMID:33130983] | ["Li Y", "Men Y", "Wang B", "Chen X", "Y | Journal of materials science. | 2020 | 0 |
| Generation of Functional Human 3D Cortico-Motor Assembloids. [PMID:33333020] | ["Andersen J", "Revah O", "Miura Y", "Th | Cell | 2020 | 0 |