concept

SEROTONIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SEROTONIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

221Connections

0Hypotheses

0Analyses

29Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	SEROTONIN
Key Genes/Proteins	BDNF, AKT, AMYLOID, PI3K, IL-6
Related Diseases	ALZHEIMER'S DISEASE, PARKINSON'S DISEASE, DEPRESSION, OBESITY
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    SEROTONIN["SEROTONIN"]
    style SEROTONIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    SEROTONIN -.->|"protects against"| Depression["Depression"]
    SEROTONIN -->|"regulates"| NEURONAL_PLASTICITY["NEURONAL PLASTICITY"]
    SEROTONIN -->|"modulates"| GAPDH([GAPDH])
    SEROTONIN -->|"regulates"| Neuronal_Plasticity["Neuronal Plasticity"]
    SEROTONIN -->|"modulates"| SERT([SERT])
    SEROTONIN -->|"involved_in"| Hippocampus_Dependent_Learning["Hippocampus-Dependent Learning"]
    SEROTONIN -->|"regulates"| Neuronal_Maturation["Neuronal Maturation"]
    Exercise["Exercise"] -->|"upregulates"| SEROTONIN
    AADC["AADC"] -->|"catalyzes"| SEROTONIN
    Tryptophan["Tryptophan"] -->|"interacts"| SEROTONIN
    SSRIs{"SSRIs"} -->|"targets"| SEROTONIN
    Circadian_Clock_Genes["Circadian Clock Genes"] -->|"regulates"| SEROTONIN
    SERT -->|"regulates"| SEROTONIN
    exercise["exercise"] -->|"activates"| SEROTONIN
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"regulates"| SEROTONIN
    AMYLOID([AMYLOID]) -->|"activates"| SEROTONIN

Outgoing (70)

Target	Relation	Type	Str
NEURONAL PLASTICITY	regulates	entity	0.90
DEPRESSION	associated_with	entity	0.90
ALZHEIMER'S DISEASE	associated_with	entity	0.85
NEURONS	produces	cell_type	0.70
MELATONIN	causes	drug	0.70
DEPRESSION	increases_risk	disease	0.65
HIPPOCAMPUS	produces	brain_region	0.65
OBESITY	produces	disease	0.65
FLUOXETINE	inhibits	drug	0.65
BIPOLAR DISORDER	regulates	disease	0.65
DEPRESSION	causes	disease	0.65
ALZHEIMER'S DISEASE	targets	disease	0.65
MITOPHAGY	regulates	phenotype	0.65
MITOPHAGY	interacts_with	phenotype	0.65
MITOCHONDRIAL DYSFUNCTION	exacerbates	phenotype	0.65
CORTEX	treats	brain_region	0.65
SCHIZOPHRENIA	causes	disease	0.65
HIPPOCAMPUS	causes	brain_region	0.65
HIPPOCAMPUS	inhibits	brain_region	0.65
OXIDATIVE STRESS	activates	phenotype	0.65
OXIDATIVE STRESS	inhibits	phenotype	0.65
NEUROINFLAMMATION	inhibits	phenotype	0.65
HIPPOCAMPUS	implicated_in	brain_region	0.55
OBESITY	depleted_in	disease	0.55
DOPAMINERGIC NEURONS	activates	concept	0.50
LEVODOPA	associated_with	drug	0.50
L-DOPA	associated_with	drug	0.45
CORTEX	associated_with	brain_region	0.45
SERTRALINE	associated_with	drug	0.45

Incoming (151)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	0.90
PARKINSON'S DISEASE	associated_with	disease	0.74
BDNF	associated_with	gene	0.74
AKT	associated_with	gene	0.66
AMYLOID	associated_with	protein	0.66
PI3K	associated_with	gene	0.66
IL-6	associated_with	gene	0.66
TAU	regulates	protein	0.65
NEURONS	causes	cell_type	0.65
ATP	inhibits	phenotype	0.65
NEUROINFLAMMATION	causes	phenotype	0.65
KYNURENINE PATHWAY	activates	pathway	0.65
TNF	associated_with	gene	0.56
NEUROGENESIS	implicated_in	phenotype	0.55
ALZHEIMER	regulates	gene	0.50
Alzheimer'S Disease	regulates	disease	0.50
ANXIETY	regulates	gene	0.50
disease	regulates	disease	0.50
ALZHEIMER'S	regulates	concept	0.50
NEURONS	associated_with	concept	0.50
AUTISM	activates	disease	0.50
DEPRESSION	activates	disease	0.50
SCHIZOPHRENIA	activates	disease	0.50
ALZHEIMER	activates	gene	0.50
Alzheimer'S Disease	activates	disease	0.50
disease	activates	disease	0.50
ALZHEIMER'S	activates	concept	0.50
DEPRESSION	associated_with	disease	0.50
aging	associated_with	phenotype	0.50
disease	associated_with	disease	0.50
DEMENTIA	associated_with	gene	0.50
HTTLPR	activates	concept	0.50
Hippocampus	activates	entity	0.50
DOPAMINE	activates	concept	0.50
Hippocampus	associated_with	entity	0.50
DOPAMINE	associated_with	concept	0.50
Neuroinflammation	regulates	process	0.50
CLOCK	regulates	gene	0.50
GABA	regulates	gene	0.50
oxidative stress	regulates	phenotype	0.50
Synaptic Plasticity	regulates	pathway	0.50
DOPAMINE	regulates	concept	0.50
acetylcholine	regulates	disease	0.50
mTOR	regulates	entity	0.50
NF-κB	regulates	concept	0.50
Chemoresistance	regulates	pathway	0.50
Neuroinflammation	activates	process	0.50
P2Y12	activates	protein	0.50
MULTIPLE SCLEROSIS	activates	disease	0.50
EXERCISE	causes	concept	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SEROTONIN

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

primary-progressive-aphasia

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

PD Combination Therapy Matrix

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Multiple System Atrophy

GSK-3β in Neurodegeneration

Circadian Rhythm in Neurodegeneration

rasagiline

substantia-nigra

Spinal Cord Dorsal Horn Neurons

Paraventricular Hypothalamic Nucleus (PVN) Neurons

Spinal Cord Stimulation-Affected Neurons

ZDHHC13 — Zinc Finger DHHC-Type Containing 13

Locus Coeruleus Alpha Neurons