gene

SV2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SV2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

34Connections
0Hypotheses
0Analyses
23Outgoing
11Incoming

Summary

SV2A — Synaptic Vesicle Protein 2A

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🧬 Gene Info
Gene SymbolSV2A
Full NameSynaptic Vesicle Protein 2A
Chromosome1p31.1
Protein TypeTransporter
FunctionSV2A is an integral membrane protein localized to synaptic vesicles
Subcellular Localizationsynaptic vesicles:
PathwaysSynaptic vesicle formation
UniProt IDQ9H0Y5
NCBI Gene ID9902
Ensembl IDENSG00000159166
OMIM158621
GeneCardsSV2A
Human Protein AtlasSV2A
DiseaseMechanism
Alzheimer's DiseaseSV2A expression reduced in AD brains; involved in synaptic loss
Associated DiseasesALS
InteractionsProteins, SNAP25, SYNAPTOPHYSIN, GAP43, PSD95, GFAP
KG Connections34 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: SV2A — AlphaFold Q9H0Y5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

SV2A — Synaptic Vesicle Protein 2A

gene · 971 words

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

mechanism · 6138 words

gabaergic-dysfunction

mechanism · 4621 words

Synaptic Vesicle Trafficking in Parkinson's Disease

mechanism · 4417 words

Neurogenesis

cell · 3757 words

Synaptic Plasticity Deficits in Neurodegeneration

mechanism · 3654 words

Pathway Diagram

flowchart TD
    N0["SV2A"]
    N1["Anxiety"]
    N0 -->|"interacts with"| N1
    N2["ALS"]
    N0 -->|"associated with"| N2
    N3["neuroplasticity"]
    N0 -->|"involved in"| N3
    N4["GAP43"]
    N0 -->|"associated with"| N4
    N5["PSD95"]
    N0 -->|"associated with"| N5
    N6["AND"]
    N0 -->|"associated with"| N6
    N7["SYNAPTOPHYSIN"]
    N0 -->|"associated with"| N7
    N8["SAPAP3"]
    N0 -->|"associated with"| N8
    N9["ANXIETY"]
    N9 -->|"interacts with"| N0
    N10["Amygdala"]
    N0 -->|"expressed in"| N10
    N11["Cortex"]
    N0 -->|"expressed in"| N11
    N12["Hippocampus"]
    N0 -->|"expressed in"| N12
    N13["Striatum"]
    N0 -->|"expressed in"| N13
    N14["Proteins"]
    N0 -->|"interacts with"| N14

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene
    class N9 gene
    class N14 protein

Outgoing (23)

TargetRelationTypeStr
SYPcorrelates_withprotein0.95
Alzheimer's diseasebiomarker_fordisease0.95
SYPco_expressed_withprotein0.90
Synaptic vesicle formationinvolved_inprocess0.90
Synaptic densitybiomarker_forbiomarker0.90

Incoming (11)

SourceRelationTypeStr
FTLD-GRNdownregulatesdisease0.92
EOADdownregulatesdisease0.90
APOE Ε4downregulatesgene0.88
LOADdownregulatesdisease0.85
PSPdownregulatesdisease0.75

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found