Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SV2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SV2A |
| Full Name | Synaptic Vesicle Protein 2A |
| Chromosome | 1p31.1 |
| Protein Type | Transporter |
| Function | SV2A is an integral membrane protein localized to synaptic vesicles |
| Subcellular Localization | synaptic vesicles: |
| Pathways | Synaptic vesicle formation |
| UniProt ID | Q9H0Y5 |
| NCBI Gene ID | 9902 |
| Ensembl ID | ENSG00000159166 |
| OMIM | 158621 |
| GeneCards | SV2A |
| Human Protein Atlas | SV2A |
| Disease | Mechanism |
| Alzheimer's Disease | SV2A expression reduced in AD brains; involved in synaptic loss |
| Associated Diseases | ALS |
| Interactions | Proteins, SNAP25, SYNAPTOPHYSIN, GAP43, PSD95, GFAP |
| KG Connections | 34 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["SV2A"]
N1["Anxiety"]
N0 -->|"interacts with"| N1
N2["ALS"]
N0 -->|"associated with"| N2
N3["neuroplasticity"]
N0 -->|"involved in"| N3
N4["GAP43"]
N0 -->|"associated with"| N4
N5["PSD95"]
N0 -->|"associated with"| N5
N6["AND"]
N0 -->|"associated with"| N6
N7["SYNAPTOPHYSIN"]
N0 -->|"associated with"| N7
N8["SAPAP3"]
N0 -->|"associated with"| N8
N9["ANXIETY"]
N9 -->|"interacts with"| N0
N10["Amygdala"]
N0 -->|"expressed in"| N10
N11["Cortex"]
N0 -->|"expressed in"| N11
N12["Hippocampus"]
N0 -->|"expressed in"| N12
N13["Striatum"]
N0 -->|"expressed in"| N13
N14["Proteins"]
N0 -->|"interacts with"| N14
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 disease
class N4 gene
class N5 gene
class N6 gene
class N7 gene
class N8 gene
class N9 gene
class N14 protein| Target | Relation | Type | Str |
|---|---|---|---|
| SYP | correlates_with | protein | 0.95 |
| Alzheimer's disease | biomarker_for | disease | 0.95 |
| SYP | co_expressed_with | protein | 0.90 |
| Synaptic vesicle formation | involved_in | process | 0.90 |
| Synaptic density | biomarker_for | biomarker | 0.90 |
| AΒ | correlates_with | protein | 0.85 |
| SNAP25 | interacts_with | protein | 0.85 |
| SYNAPTOTAGMINS | co_expressed_with | protein | 0.85 |
| GAP43 | co_expressed_with | protein | 0.85 |
| PHOSPHO-TAU | correlates_with | protein | 0.85 |
| Anxiety | interacts_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| neuroplasticity | involved_in | biological_process | 0.60 |
| GAP43 | associated_with | gene | 0.60 |
| PSD95 | associated_with | gene | 0.60 |
| SYNAPTOPHYSIN | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| SAPAP3 | associated_with | gene | 0.60 |
| Amygdala | expressed_in | brain_region | 0.55 |
| Striatum | expressed_in | brain_region | 0.55 |
| Cortex | expressed_in | brain_region | 0.55 |
| Hippocampus | expressed_in | brain_region | 0.55 |
| Proteins | interacts_with | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| FTLD-GRN | downregulates | disease | 0.92 |
| EOAD | downregulates | disease | 0.90 |
| APOE Ε4 | downregulates | gene | 0.88 |
| LOAD | downregulates | disease | 0.85 |
| PSP | downregulates | disease | 0.75 |
| GFAP | interacts_with | gene | 0.60 |
| ANXIETY | interacts_with | gene | 0.60 |
| SAPAP3 | interacts_with | gene | 0.60 |
| SYNAPTOPHYSIN | interacts_with | gene | 0.50 |
| GAP43 | interacts_with | protein | 0.50 |
| PSD95 | interacts_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||