Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NGN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NGN2 encodes a bHLH transcription factor that acts as a master regulator of excitatory neuronal fate determination. Essential for cortical development, neuronal differentiation, and neurogenesis. Linked to neurodevelopmental disorders and neurodegeneration.
| Gene Symbol | NGN2 (NEUROG2) |
| Full Name | Neurogenin-2 |
| Chromosome | 4q21.1 |
| Function | regulator of excitatory neuronal fate determination |
| Molecular Weight | 34.7 kDa |
| Amino Acids | 199 aa |
| Exons | 2 |
| Pathways | Notch signaling |
| UniProt ID | Q9HSY5 |
| NCBI Gene ID | 63973 |
| Ensembl ID | ENSG00000174348 |
| OMIM | 607574 |
| Encoded Protein | Ngn2 (Neurogenin-2) |
| Strand | Minus strand |
| Transcript length | ~1.8 kb coding region |
| Associated Diseases | ALS |
| Interactions | DISC1, NGN1, GENES |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NGN2["<b>NGN2</b>"]
Schizophrenia{"Schizophrenia"}
NGN2 -->|"activates"| Schizophrenia
Aging{"Aging"}
NGN2 -->|"activates"| Aging
Depression{"Depression"}
NGN2 -->|"activates"| Depression
Bipolar{"Bipolar"}
NGN2 -->|"activates"| Bipolar
Ms{"Ms"}
NGN2 -->|"activates"| Ms
DISC1["DISC1"]
NGN2 -->|"activates"| DISC1
ASCL1["ASCL1"]
NGN2 -->|"associated with"| ASCL1
DLX2["DLX2"]
NGN2 -->|"associated with"| DLX2
neurodegeneration["neurodegeneration"]
NGN2 -->|"implicated in"| neurodegeneration
style NGN2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Schizophrenia | activates | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| Depression | activates | disease | 0.65 |
| Bipolar | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| DISC1 | activates | gene | 0.60 |
| ASCL1 | associated_with | gene | 0.60 |
| DLX2 | associated_with | gene | 0.60 |
| MEF2C | regulates | gene | 0.60 |
| EPHA5 | regulates | gene | 0.60 |
| NLGN1 | regulates | gene | 0.60 |
| DCC | regulates | gene | 0.60 |
| NGN1 | regulates | gene | 0.60 |
| Neuron | therapeutic_target | cell_type | 0.60 |
| AND | regulates | gene | 0.60 |
| App | therapeutic_target | protein | 0.60 |
| stem cells | expressed_in | cell_type | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| ALS | associated_with | disease | 0.60 |
| Cortex | expressed_in | brain_region | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| Cortex | regulates | brain_region | 0.50 |
| NEURONS | associated_with | concept | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||