Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NMDA-RECEPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | NMDA |
| Full Name | RECEPTOR |
| Aliases | GRIN2B, GRIN1 |
| Molecular Weight | 166 kDa |
| Pathways | glutamate signaling, unfolded protein response, oxidative stress response, mitochondrial function, sphingolipid metabolism |
| GeneCards | NMDA |
| Human Protein Atlas | NMDA |
| Associated Diseases | ALS, Alzheimer, Alzheimer'S Disease, Huntington, disease, epilepsy |
| Known Drugs/Compounds | memantine |
| Interactions | SLC17A7, PSD-95, TET2, ROS, VPS35, P2Y12 |
| KG Connections | 134 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
NMDA_RECEPTOR(["NMDA-RECEPTOR"])
NEUROTOXICITY("NEUROTOXICITY")
ALZHEIMER(["ALZHEIMER"])
Alzheimer_S_Disease["Alzheimer'S Disease"]
disease["disease"]
ALZHEIMER_S("ALZHEIMER'S")
NMDA(["NMDA"])
Neurodegeneration["Neurodegeneration"]
NMDA_RECEPTOR -->|"protects against"| NEUROTOXICITY
NMDA_RECEPTOR -->|"associated with"| ALZHEIMER
NMDA_RECEPTOR -->|"associated with"| Alzheimer_S_Disease
NMDA_RECEPTOR -->|"associated with"| disease
NMDA_RECEPTOR -->|"associated with"| ALZHEIMER_S
NMDA -->|"protects against"| NMDA_RECEPTOR
NMDA -->|"associated with"| NMDA_RECEPTOR
Neurodegeneration -->|"protects against"| NMDA_RECEPTOR
style NMDA_RECEPTOR fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| NEUROTOXICITY | protects_against | concept | 0.50 |
| ALZHEIMER | associated_with | gene | 0.50 |
| Alzheimer'S Disease | associated_with | disease | 0.50 |
| disease | associated_with | disease | 0.50 |
| ALZHEIMER'S | associated_with | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NMDA | protects_against | protein | 0.50 |
| NMDA | associated_with | protein | 0.50 |
| Neurodegeneration | protects_against | disease | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||