concept

MEMANTINE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MEMANTINE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

134Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

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💡 Concept Info

Name	MEMANTINE
Key Genes/Proteins	AKT, AMPK, AMYLOID, APP, BDNF, CREB
Related Diseases	ACETYLCHOLINE, ALZHEIMER, ALZHEIMER'S DISEASE, ALZHEIMERS_DISEASE, CHOLESTEROL

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Memantine - NMDA Antagonist for Alzheimer's Disease

therapeutic · 847 words

→

Pathway Diagram

graph TD
    MEMANTINE["MEMANTINE"]
    MEMANTINE -->|"inhibits"| NMDA_RECEPTOR["NMDA RECEPTOR"]
    MEMANTINE -->|"treats"| Dementia["Dementia"]
    MEMANTINE -->|"treats"| Alzheimer_S_Disease["Alzheimer'S Disease"]
    MEMANTINE -->|"treats"| Moderate_To_Severe_Dementia["Moderate To Severe Dementia"]
    MEMANTINE -->|"treats"| Alzheimer_s_Disease["Alzheimer's Disease"]
    MEMANTINE -->|"promotes"| Functional_Stabilization["Functional Stabilization"]
    MEMANTINE -->|"activates"| NRF2["NRF2"]
    MEMANTINE -->|"activates"| NMDA["NMDA"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"target for"| MEMANTINE
    DEMENTIA["DEMENTIA"] -->|"inhibits"| MEMANTINE
    CREB["CREB"] -->|"activates"| MEMANTINE
    EXCITOTOXICITY["EXCITOTOXICITY"] -->|"activates"| MEMANTINE
    DONEPEZIL["DONEPEZIL"] -->|"activates"| MEMANTINE
    APP["APP"] -->|"produces"| MEMANTINE

Outgoing (83)

Target	Relation	Type	Str
ad_clinical_trial_failures:memantine	data_in	dataset_row	0.00
ad_clinical_trial_failures:memantine	data_in	dataset_row	0.00
Moderate To Severe Dementia	treats	disease	0.90
Alzheimer'S Disease	treats	disease	0.90
Dementia	treats	disease	0.90
Alzheimer's Disease	treats	disease	0.85
Functional Stabilization	promotes	phenotype	0.85
Nrf2 Pathway	activates	pathway	0.80
Nrf2	activates	pathway	0.80
NMDA receptor	inhibits	receptor	0.80
glutamate signaling	modulates	pathway	0.80
NRF2	activates	protein	0.80
CREB/RCAN1	activates	pathway	0.80
Oxidative Stress	associated_with	process	0.75
Alzheimer's Disease	treats	disease	0.75
NMDA	activates	entity	0.70
NMDA	inhibits	entity	0.70
unfolded protein response	modulates	pathway	0.70
CSF tracer clearance	enhances	gene	0.70
Alzheimer's disease	treats	disease	0.70
NEURODEGENERATION	exacerbates	disease	0.65
MICROGLIA	treats	cell_type	0.65
NEURODEGENERATION	activates	disease	0.65
NMDAR	treats	gene	0.65
TAU	phosphorylates	gene	0.65
NEURODEGENERATION	inhibits	phenotype	0.65
NEURODEGENERATION	regulates	phenotype	0.65
INFLAMMATION	activates	phenotype	0.65
AKT	regulates	gene	0.65
AKT	inhibits	gene	0.65
AKT	treats	gene	0.65
NMDAR	inhibits	gene	0.65
NMDAR	regulates	gene	0.65
NEURON	protects_against	cell_type	0.65
NEURONS	protects_against	cell_type	0.65
TAU	transports	gene	0.65
ALZHEIMERS_DISEASE	treats	disease	0.64
NMDA receptor	treats	receptor	0.60
depression	treats	disease	0.60
neuroinflammation	treats	disease	0.60
APP	targets	gene	0.60
HSP60	targets	gene	0.60
APP	inhibits	gene	0.60
NMDA	targets	gene	0.60
neurodegeneration	treats	disease	0.60
NMDA receptor	activates	receptor	0.60
RCAN1	targets	gene	0.60
APP	associated_with	gene	0.60
CREB	targets	gene	0.60
oxidative stress response	modulates	pathway	0.60

Incoming (51)

Source	Relation	Type	Str
ad_clinical_trial_failures:memantine	data_in	dataset_row	0.00
ad_clinical_trial_failures:memantine	data_in	dataset_row	0.00
CHOLINERGIC	promotes	cell_type	0.65
APP	transports	gene	0.65
RIBOSOME	produces	organelle	0.65
ALZHEIMER'S DISEASE	regulates	disease	0.65
AKT	phosphorylates	gene	0.65
ALZHEIMER	treats	disease	0.65
ALZHEIMER'S DISEASE	treats	disease	0.65
NEURON	treats	cell_type	0.65
DONEPEZIL	associated_with	drug	0.65
ALZHEIMER	causes	disease	0.65
GALANTAMINE	activates	drug	0.65
EMPAGLIFLOZIN	treats	drug	0.65
38101486	delayed	paper	0.60
38101486	delays	paper	0.60
ACETYLCHOLINE	associated_with	phenotype	0.50
DOPAMINERGIC NEURONS	associated_with	cell_type	0.50
PARKINSON'S DISEASE	associated_with	disease	0.50
INFLAMMATION	associated_with	phenotype	0.50
CHOLESTEROL	associated_with	phenotype	0.50
NEURODEGENERATION	associated_with	phenotype	0.50
MELATONIN	associated_with	drug	0.45
CREB	associated_with	gene	0.45
ALZHEIMER	associated_with	disease	0.45
TAU PHOSPHORYLATION	associated_with	phenotype	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
DEMENTIA	associated_with	disease	0.45
TIDEGLUSIB	associated_with	drug	0.45
NRF2 PATHWAY	associated_with	pathway	0.45
PRAMIPEXOLE	associated_with	drug	0.45
COGNITIVE DECLINE	associated_with	phenotype	0.45
EMPAGLIFLOZIN	associated_with	drug	0.45
BARICITINIB	associated_with	drug	0.45
GLUTAMATE EXCITOTOXICITY	associated_with	phenotype	0.45
GLUTAMATE	associated_with	phenotype	0.45
AKT	associated_with	gene	0.45
GALANTAMINE	associated_with	drug	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.45
EXCITOTOXICITY	associated_with	phenotype	0.45
RIVASTIGMINE	associated_with	drug	0.45
AKT	activates	gene	0.35
ALZHEIMER'S DISEASE	activates	disease	0.35
APP	therapeutic_target	gene	0.35
DEMENTIA	inhibits	disease	0.35
ALZHEIMER'S DISEASE	therapeutic_target	disease	0.35
CREB	activates	gene	0.35
EXCITOTOXICITY	activates	process	0.35
DONEPEZIL	activates	drug	0.35
APP	produces	gene	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance

neuroscience | 2026-04-28 | 7 hypotheses Top: 0.808

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Structured research brief for hypothesis h-var-e2b5a7e7db: GluN2B-Mediated Thala

closed · Rounds: 4 · Score: 0.82 · 2026-04-28

Related Research

Hypotheses and analyses mentioning MEMANTINE in their description or question text

No additional research found