gene

NQO2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NQO2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

0Hypotheses

0Analyses

18Outgoing

1Incoming

0Experiments

0Debates

Summary

NQO2 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, implicated in. Associated with Atherosclerosis, Fatty Liver, Inflammation. Connected to 20 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NQO2
Full Name	NAD(P)H Quinone Dehydrogenase 2
Aliases	NAD(P
Chromosome	6p25.2
Protein Type	Enzyme
Function	NQO2 performs essential protective functions
Molecular Weight	25 kDa
Amino Acids	231 aa
Pathways	Cholesterol, Lipid Metabolism
UniProt ID	P16083
NCBI Gene ID	4835
Ensembl ID	ENSG00000124368
OMIM	160425
GeneCards	NQO2
Human Protein Atlas	NQO2
Associated Diseases	neurodegeneration
Interactions	INFLAMMATION, KEAP1, LDL
KG Connections	19 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NQO2 — AlphaFold P16083 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NQO2 Gene

gene · 553 words

→

NQO2 (NAD(P)H Quinone Dehydrogenase 2)

protein · 643 words

→

Pathway Diagram

graph TD
    NQO2["NQO2
NAD(P)H Quinone
Dehydrogenase 2"]
    
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    NRF2["NRF2
Nuclear Factor
Erythroid 2"]
    KEAP1["KEAP1
Kelch ECH
Associated Protein 1"]
    HMOX1["HMOX1
Heme Oxygenase 1"]
    ANTIOXIDANT_GENES["Antioxidant
Response Genes"]
    
    FERROPTOSIS["FERROPTOSIS"]
    GPX4["GPX4
Glutathione
Peroxidase 4"]
    
    INFLAMMATION_GENE["Inflammatory
Gene Expression"]
    LIPID_METABOLISM["Lipid Metabolism
Dysregulation"]
    LDL["LDL
Oxidation"]
    
    NEURODEGENERATION["Neurodegeneration"]
    METABOLIC_SYNDROME["Metabolic
Syndrome"]
    ATHEROSCLEROSIS["Atherosclerosis"]
    
    NQO2 -->|"associated with"| OXIDATIVE_STRESS
    NQO2 -->|"activates"| KEAP1
    NQO2 -->|"associated with"| NRF2
    KEAP1 -->|"inhibits"| NRF2
    NRF2 -->|"activates"| HMOX1
    NRF2 -->|"activates"| ANTIOXIDANT_GENES
    
    NQO2 -->|"associated with"| FERROPTOSIS
    GPX4 -->|"inhibits"| FERROPTOSIS
    FERROPTOSIS -->|"promotes"| NEURODEGENERATION
    
    NQO2 -->|"activates"| INFLAMMATION_GENE
    NQO2 -->|"activates"| LIPID_METABOLISM
    NQO2 -->|"activates"| LDL
    
    OXIDATIVE_STRESS -->|"contributes to"| NEURODEGENERATION
    INFLAMMATION_GENE -->|"promotes"| NEURODEGENERATION
    
    LIPID_METABOLISM -->|"leads to"| METABOLIC_SYNDROME
    LDL -->|"promotes"| ATHEROSCLEROSIS
    
    style NQO2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style HMOX1 fill:#1b5e20,stroke:#333,stroke-width:2px
    style ANTIOXIDANT_GENES fill:#1b5e20,stroke:#333,stroke-width:2px
    style GPX4 fill:#1b5e20,stroke:#333,stroke-width:2px
    style NRF2 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style KEAP1 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style OXIDATIVE_STRESS fill:#ef5350,stroke:#333,stroke-width:2px,color:#e0e0e0
    style FERROPTOSIS fill:#ef5350,stroke:#333,stroke-width:2px,color:#e0e0e0
    style INFLAMMATION_GENE fill:#ef5350,stroke:#333,stroke-width:2px,color:#e0e0e0
    style NEURODEGENERATION fill:#7d4200,stroke:#333,stroke-width:2px
    style METABOLIC_SYNDROME fill:#7d4200,stroke:#333,stroke-width:2px
    style ATHEROSCLEROSIS fill:#7d4200,stroke:#333,stroke-width:2px

Outgoing (18)

Target	Relation	Type	Str
Fatty Liver	activates	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Nafld	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Inflammation	activates	disease	0.65
Ferroptosis	associated_with	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Cholesterol	activates	pathway	0.60
FERROPTOSIS	associated_with	gene	0.60
Lipid Metabolism	activates	pathway	0.60
INFLAMMATION	activates	gene	0.60
GENES	associated_with	gene	0.60
LDL	activates	gene	0.60
ANTIOXIDANT GENES	associated_with	gene	0.60
KEAP1	activates	gene	0.60
HMOX1	associated_with	gene	0.60
NRF2	associated_with	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60

Incoming (1)

Source	Relation	Type	Str
GPX4	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NQO2 in their description or question text

No additional research found