Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Nafld: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | DIABETES MELLITUS, AUTOPHAGY, APOPTOSIS, INFLAMMATION, SIRT1, CYP2E1, CYP3A4, NEURODEGENERATION |
| KG Connections | 257 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
Nafld["<b>Nafld</b>"]
Fatty_Liver{"Fatty Liver"}
Nafld -->|"associated_with"| Fatty_Liver
Liver_Cirrhosis{"Liver Cirrhosis"}
Nafld -->|"contributes_to"| Liver_Cirrhosis
Hepatocellular_Carcinoma{"Hepatocellular Carcinoma"}
Nafld -->|"contributes_to"| Hepatocellular_Carcinoma
Inflammation{"Inflammation"}
Nafld -->|"therapeutic_target"| Inflammation
Hfd["Hfd"]
Hfd -->|"causes"| Nafld
INFLAMMATION(["INFLAMMATION"])
INFLAMMATION -->|"therapeutic_target"| Nafld
Als{"Als"}
Als -->|"therapeutic_target"| Nafld
Autophagy["Autophagy"]
Autophagy -->|"involved_in"| Nafld
style Nafld fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Fatty Liver | associated_with | disease | 1.00 |
| Liver Cirrhosis | contributes_to | disease | 0.95 |
| Hepatocellular Carcinoma | contributes_to | disease | 0.95 |
| Fatty Liver | therapeutic_target | disease | 0.85 |
| Inflammation | therapeutic_target | disease | 0.85 |
| Fatty Liver | contributes_to | disease | 0.85 |
| Fatty Liver | treats | disease | 0.85 |
| Lipid Metabolism | regulates | pathway | 0.80 |
| Oxidative Stress | activates | pathway | 0.80 |
| Mtor | activates | pathway | 0.80 |
| Inflammation | associated_with | disease | 0.75 |
| Lipid Metabolism | activates | pathway | 0.70 |
| Autophagy | regulates | pathway | 0.70 |
| Mtor | therapeutic_target | pathway | 0.70 |
| Er Stress | associated_with | pathway | 0.70 |
| Apoptosis | associated_with | pathway | 0.70 |
| Als | activates | disease | 0.65 |
| Obesity | therapeutic_target | disease | 0.65 |
| Insulin Resistance | therapeutic_target | disease | 0.65 |
| Fatty Liver | causes | disease | 0.65 |
| Hepatitis | associated_with | disease | 0.65 |
| Fatty Liver | activates | disease | 0.65 |
| Hepatitis | treats | disease | 0.65 |
| Fatty Liver | biomarker_for | disease | 0.65 |
| Lipid Metabolism | implicated_in | pathway | 0.60 |
| Microbiota | activates | pathway | 0.60 |
| Jak-Stat | activates | pathway | 0.60 |
| Foxo Signaling | activates | pathway | 0.60 |
| Gut Microbiome | activates | pathway | 0.60 |
| Glycolysis | activates | pathway | 0.60 |
| Microbiota | regulates | pathway | 0.60 |
| Senescence | regulates | pathway | 0.60 |
| Inflammasome | regulates | pathway | 0.60 |
| Nf-Κb | regulates | pathway | 0.60 |
| Lipid Metabolism | causes | pathway | 0.60 |
| Immune Response | therapeutic_target | pathway | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| Cholesterol | inhibits | pathway | 0.60 |
| Chaperone | therapeutic_target | pathway | 0.60 |
| Unfolded Protein Response | therapeutic_target | pathway | 0.60 |
| Proteasome | regulates | pathway | 0.60 |
| Mitophagy | therapeutic_target | pathway | 0.60 |
| Inflammasome | activates | pathway | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Chaperone | regulates | pathway | 0.60 |
| Ferroptosis | therapeutic_target | pathway | 0.60 |
| Complement | therapeutic_target | pathway | 0.60 |
| Microrna | therapeutic_target | pathway | 0.60 |
| Oxidative Stress | treats | pathway | 0.60 |
| Oxidative Stress | inhibits | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Hfd | causes | phenotype | 0.95 |
| INFLAMMATION | therapeutic_target | gene | 0.95 |
| Als | therapeutic_target | disease | 0.95 |
| Autophagy | involved_in | process | 0.90 |
| Lipid Droplets | associated_with | phenotype | 0.85 |
| PI3K | activates | gene | 0.85 |
| AKT | activates | gene | 0.85 |
| OXIDATIVE STRESS | activates | gene | 0.85 |
| MTOR | activates | gene | 0.85 |
| INFLAMMATION | associated_with | gene | 0.85 |
| Hepatocellular Carcinoma | therapeutic_target | disease | 0.75 |
| Carcinoma | therapeutic_target | disease | 0.75 |
| LDL | activates | gene | 0.75 |
| GENES | activates | gene | 0.75 |
| INSULIN RESISTANCE | therapeutic_target | gene | 0.75 |
| AUTOPHAGY | regulates | gene | 0.75 |
| DIABETES MELLITUS | causes | gene | 0.75 |
| MTORC1 | therapeutic_target | gene | 0.75 |
| LIPOPHAGY | therapeutic_target | gene | 0.75 |
| MTOR | therapeutic_target | gene | 0.75 |
| APOPTOSIS | associated_with | gene | 0.75 |
| Cancer | associated_with | disease | 0.75 |
| NRF2 | activates | gene | 0.75 |
| Fibrosis | therapeutic_target | disease | 0.75 |
| CANCER | associated_with | gene | 0.75 |
| CANCER | therapeutic_target | gene | 0.65 |
| IL-6 | activates | gene | 0.65 |
| JAK | activates | gene | 0.65 |
| ROS | therapeutic_target | gene | 0.65 |
| NF-ΚB | regulates | gene | 0.65 |
| MITOCHONDRIAL DYSFUNCTION | regulates | gene | 0.65 |
| AUTOPHAGY | associated_with | gene | 0.65 |
| APOE | inhibits | gene | 0.65 |
| Liver Cancer | associated_with | disease | 0.65 |
| UBIQUITIN | therapeutic_target | gene | 0.65 |
| DIABETES MELLITUS | activates | gene | 0.65 |
| Diabetes | activates | disease | 0.65 |
| PTEN | activates | gene | 0.65 |
| PINK1 | therapeutic_target | gene | 0.65 |
| MITOPHAGY | therapeutic_target | gene | 0.65 |
| NLRP3 | activates | gene | 0.65 |
| MITOCHONDRIA | activates | gene | 0.65 |
| PARKIN | activates | gene | 0.65 |
| APOE | expressed_in | gene | 0.65 |
| PPAR | activates | gene | 0.65 |
| ATG | activates | gene | 0.65 |
| AMPK | activates | gene | 0.65 |
| HO-1 | activates | gene | 0.65 |
| AUTOPHAGY | activates | gene | 0.65 |
| LYSOSOME | regulates | gene | 0.65 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||