Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NEUROFILAMENT LIGHT CHAIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | NEUROFILAMENT LIGHT CHAIN |
| Molecular Weight | 61.5 kDa |
| Amino Acids | 543 aa |
| NfL (Light chain, 61 kDa) | The smallest subunit, essential for filament assembly |
| NfM (Medium chain, 95 kDa) | Phosphorylated on serine residues in the tail domain |
| NfH (Heavy chain, 200 kDa) | Heavily phosphorylated, regulates axonal caliber |
| Associated Diseases | Amyotrophic Lateral Sclerosis, Multiple Sclerosis |
| Interactions | PHOSPHORYLATED TAU, AMYLOID, IL10, IL18 |
| KG Connections | 16 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NEUROFILAMENT_LIGHT_CHAIN["NEUROFILAMENT LIGHT CHAIN"]
NEUROFILAMENT_LIGHT_CHAIN -.biomarker for.-> Neuro_Axonal_Injury["Neuro-Axonal Injury"]
NEUROFILAMENT_LIGHT_CHAIN -.biomarker for.-> Neurodegeneration["Neurodegeneration"]
NEUROFILAMENT_LIGHT_CHAIN -->|"involved_in"| Neurological_Disease_Managemen["Neurological Disease Management"]
NEUROFILAMENT_LIGHT_CHAIN -->|"activates"| PHOSPHORYLATED_TAU["PHOSPHORYLATED TAU"]
NEUROFILAMENT_LIGHT_CHAIN -->|"activates"| AMYLOID["AMYLOID"]
NEUROFILAMENT_LIGHT_CHAIN -->|"activates"| CYTOKINES["CYTOKINES"]
NEUROFILAMENT_LIGHT_CHAIN -->|"activates"| TAU_PATHOLOGY["TAU PATHOLOGY"]
NEUROFILAMENT_LIGHT_CHAIN -->|"activates"| ENDOTHELIAL["ENDOTHELIAL"]
Neurodegeneration -->|"activates"| NEUROFILAMENT_LIGHT_CHAIN
IL10["IL10"] -->|"activates"| NEUROFILAMENT_LIGHT_CHAIN
IL18["IL18"] -->|"activates"| NEUROFILAMENT_LIGHT_CHAIN| Target | Relation | Type | Str |
|---|---|---|---|
| PHOSPHORYLATED TAU | activates | protein | 0.50 |
| AMYLOID | activates | gene | 0.50 |
| CYTOKINES | activates | concept | 0.50 |
| TAU PATHOLOGY | activates | concept | 0.50 |
| ENDOTHELIAL | activates | concept | 0.50 |
| SNAP-25 | associated_with | protein | 0.50 |
| NEUROGRANIN | associated_with | protein | 0.50 |
| SYNUCLEIN | associated_with | concept | 0.50 |
| α-SYNUCLEIN | associated_with | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Neurodegeneration | associated_with | disease | 0.50 |
| Neurodegeneration | activates | disease | 0.50 |
| IL10 | activates | gene | 0.50 |
| IL18 | activates | gene | 0.50 |
| TREM2 | associated_with | gene | 0.50 |
| Neuroinflammation | associated_with | process | 0.50 |
| YKL-40 | associated_with | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||