protein

PHOSPHORYLATED TAU

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PHOSPHORYLATED TAU: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

96Connections

1Hypotheses

1Analyses

50Outgoing

30Incoming

0Experiments

1Debates

Summary

Page for Phosphorylated Tau Protein

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🔬 Protein Info

Gene Symbol	PHOSPHORYLATED TAU
Pathways	AMPK
Associated Diseases	aging, Alzheimer Disease, Alzheimer'S Disease, disease, Neuronal loss, Tauopathy
Interactions	ALZHEIMER, AMYLOID, APOE, AQP4, BETA-AMYLOID, IL10
KG Connections	62 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    PHOSPHORYLATED_TAU["PHOSPHORYLATED TAU"]
    ALZHEIMER["ALZHEIMER"]
    PHOSPHORYLATED_TAU -->|"associated with"| ALZHEIMER
    Alzheimer_S_Disease["Alzheimer'S Disease"]
    PHOSPHORYLATED_TAU -->|"associated with"| Alzheimer_S_Disease
    AMYLOID["AMYLOID"]
    PHOSPHORYLATED_TAU -->|"associated with"| AMYLOID
    disease["disease"]
    PHOSPHORYLATED_TAU -->|"associated with"| disease
    ALZHEIMER_S["ALZHEIMER'S"]
    PHOSPHORYLATED_TAU -->|"associated with"| ALZHEIMER_S
    AMYLOID__["AMYLOID-beta"]
    PHOSPHORYLATED_TAU -->|"associated with"| AMYLOID__
    NEUROFIBRILLARY_TANGLES["NEUROFIBRILLARY TANGLES"]
    PHOSPHORYLATED_TAU -->|"associated with"| NEUROFIBRILLARY_TANGLES
    NEURONS["NEURONS"]
    PHOSPHORYLATED_TAU -->|"associated with"| NEURONS
    AMYLOID___PLAQUES["AMYLOID-Beta PLAQUES"]
    PHOSPHORYLATED_TAU -->|"associated with"| AMYLOID___PLAQUES
    BETA_AMYLOID["BETA-AMYLOID"]
    PHOSPHORYLATED_TAU -->|"activates"| BETA_AMYLOID
    ALZHEIMER["ALZHEIMER"]
    PHOSPHORYLATED_TAU -->|"activates"| ALZHEIMER
    Alzheimer_S_Disease["Alzheimer'S Disease"]
    PHOSPHORYLATED_TAU -->|"activates"| Alzheimer_S_Disease
    AMYLOID["AMYLOID"]
    PHOSPHORYLATED_TAU -->|"activates"| AMYLOID
    disease["disease"]
    PHOSPHORYLATED_TAU -->|"activates"| disease
    ALZHEIMER_S["ALZHEIMER'S"]
    PHOSPHORYLATED_TAU -->|"activates"| ALZHEIMER_S
    BETA_AMYLOID["BETA-AMYLOID"]
    PHOSPHORYLATED_TAU -->|"associated with"| BETA_AMYLOID
    Neuroinflammatory["Neuroinflammatory"]
    PHOSPHORYLATED_TAU -->|"associated with"| Neuroinflammatory
    CEREBROSPINAL_FLUID["CEREBROSPINAL FLUID"]
    PHOSPHORYLATED_TAU -->|"associated with"| CEREBROSPINAL_FLUID
    AMYLOID_BETA["AMYLOID BETA"]
    PHOSPHORYLATED_TAU -->|"associated with"| AMYLOID_BETA
    Tauopathy["Tauopathy"]
    PHOSPHORYLATED_TAU -->|"associated with"| Tauopathy
    Astrocyte["Astrocyte"]
    PHOSPHORYLATED_TAU -->|"activates"| Astrocyte
    SYNAPSE["SYNAPSE"]
    PHOSPHORYLATED_TAU -->|"activates"| SYNAPSE
    aging["aging"]
    PHOSPHORYLATED_TAU -->|"associated with"| aging
    AMYLOID["AMYLOID"]
    PHOSPHORYLATED_TAU -->|"expressed in"| AMYLOID
    AMYLOID__["AMYLOID-beta"]
    PHOSPHORYLATED_TAU -->|"expressed in"| AMYLOID__
    Alzheimer_Disease["Alzheimer Disease"]
    PHOSPHORYLATED_TAU -->|"associated with"| Alzheimer_Disease
    Tauopathy["Tauopathy"]
    PHOSPHORYLATED_TAU -->|"activates"| Tauopathy
    GLIOSIS["GLIOSIS"]
    PHOSPHORYLATED_TAU -->|"activates"| GLIOSIS
    CEREBROSPINAL_FLUID["CEREBROSPINAL FLUID"]
    PHOSPHORYLATED_TAU -->|"activates"| CEREBROSPINAL_FLUID
    apoptosis["apoptosis"]
    PHOSPHORYLATED_TAU -->|"activates"| apoptosis

Outgoing (66)

Target	Relation	Type	Str
Chronic Traumatic Encephalopathy	biomarker_for	disease	0.98
Alzheimer's Disease	biomarker_for	disease	0.95
Neuronal Dysfunction	causes	phenotype	0.90
Mild Motor Deficits	biomarker_for	phenotype	0.90
Microtubule Destabilization	causes	phenotype	0.90
Neurofibrillary Tangles	causes	phenotype	0.90
Synaptic Impairment	causes	phenotype	0.90
P62	co_expressed_with	protein	0.85
Synaptic Dysfunction	contributes_to	phenotype	0.85
Neurodegeneration	contributes_to	process	0.85
Alzheimer's Disease	biomarker_for	disease	0.85
Neuronal loss	associated_with	phenotype	0.85
Amyloid-Beta Pathophysiology	associated_with	process	0.85
Kii ALS/PDC	biomarker_for	disease	0.80
Alzheimer's Disease	causes	disease	0.80
Kii Als/Pdc	biomarker_for	disease	0.80
mitophagy	inhibits	process	0.70
Alzheimer's disease	associated_with	disease	0.70
DRP1	interacts_with	protein	0.70
DRP1	interacts_with	protein	0.70
Alzheimer's disease	biomarker_for	disease	0.70
mitophagy	inhibits	process	0.70
apoptosis	activates	process	0.50
Neuroinflammatory	activates	pathway	0.50
AMYLOID	interacts_with	gene	0.50
CEREBROSPINAL FLUID	activates	concept	0.50
Tauopathy	associated_with	disease	0.50
SYNAPSE	activates	concept	0.50
aging	associated_with	phenotype	0.50
AMYLOID	expressed_in	gene	0.50
AMYLOID-β	expressed_in	concept	0.50
Alzheimer Disease	associated_with	disease	0.50
Astrocyte	activates	cell_type	0.50
ALZHEIMER	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50
AMYLOID	associated_with	gene	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
AMYLOID-β	associated_with	concept	0.50
NEUROFIBRILLARY TANGLES	associated_with	concept	0.50
NEURONS	associated_with	concept	0.50
AMYLOID-Β PLAQUES	associated_with	gene	0.50
CEREBROSPINAL FLUID	associated_with	concept	0.50
Cortex	expressed_in	brain_region	0.50
White Matter	expressed_in	process	0.50
OLIGODENDROCYTES	expressed_in	concept	0.50
GRAY MATTER	expressed_in	concept	0.50
ALZHEIMER	activates	gene	0.50
Alzheimer'S Disease	activates	disease	0.50
AMYLOID	activates	gene	0.50

Incoming (30)

Source	Relation	Type	Str
TRIAD3A	downregulates	protein	0.92
proteasomal inhibition	downregulates	mechanism	0.87
TREM2-WT	downregulates	protein	0.85
Proteasome Inhibition	downregulates	mechanism	0.85
VPS35	downregulates	protein	0.85
Indole-3-Acetic Acid	downregulates	compound	0.85
Kynurenic Acid	downregulates	compound	0.80
Microglia	interacts_with	cell_type	0.70
extracellular vesicles	mediates	process	0.70
GMNC	regulates	gene	0.70
autophagy pathway	clears	pathway	0.70
BIN1	regulates	gene	0.70
C16orf95	regulates	gene	0.70
TREM2-WT	inhibits	protein	0.70
LRP1	associated_with	gene	0.60
PHAGOCYTOSIS	activates	gene	0.50
APOE	activates	gene	0.50
microglia	activates	cell_type	0.50
AQP4	interacts_with	gene	0.50
Neurodegeneration	interacts_with	disease	0.50
Neurodegeneration	associated_with	disease	0.50
AMYLOID-BETA	associated_with	protein	0.50
late	regulates	disease	0.50
late	associated_with	disease	0.50
GFAP	associated_with	gene	0.50
Neurodegeneration	activates	disease	0.50
IL10	activates	gene	0.50
IL18	activates	gene	0.50
NEUROFILAMENT LIGHT CHAIN	activates	protein	0.50
BDNF	interacts_with	gene	0.40

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hyperphosphorylated Tau Inhibits PMCA Pumps, Causing Sustain	0.000	-	Does tau aggregation specifically cause

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the optimal oxygen pressure, duration, and frequency parameters for HBO

neurodegeneration | 2026-04-25 | 12 hypotheses Top: 0.640

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What are the optimal oxygen pressure, duration, and frequency parameters for HBO

closed · Rounds: 4 · Score: 0.68 · 2026-04-25

Related Research

Hypotheses and analyses mentioning PHOSPHORYLATED TAU in their description or question text

No additional research found