protein

YKL-40

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about YKL-40: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

53Connections

0Hypotheses

1Analyses

30Outgoing

22Incoming

Summary

Page for YKL-40 Protein

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🔬 Protein Info

Gene Symbol	YKL
Chromosome	1q32.1
Function	YKL-40, also known as chitinase 3-like protein 1 (CHI3L1), is a secreted glycoprotein belonging to the glycoside hydrolase family 18[@chitinase2020].
GeneCards	YKL
Human Protein Atlas	YKL
Associated Diseases	Alzheimer's disease
Interactions	GFAP, C3, IL-6, TET2, TREM2, CHI3L1
KG Connections	52 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    YKL_40["<b>YKL-40</b>"]
    Astrocytes["Astrocytes"]
    YKL_40 -->|"expressed_in"| Astrocytes
    Alzheimer_s_Disease{"Alzheimer's Disease"}
    YKL_40 -->|"involved_in"| Alzheimer_s_Disease
    Cerebrospinal_Fluid["Cerebrospinal Fluid"]
    YKL_40 -->|"expressed_in"| Cerebrospinal_Fluid
    Neuroinflammation["Neuroinflammation"]
    YKL_40 -->|"regulates"| Neuroinflammation
    ALZHEIMER(["ALZHEIMER"])
    YKL_40 -->|"regulates"| ALZHEIMER
    Alzheimer_S_Disease{"Alzheimer'S Disease"}
    YKL_40 -->|"regulates"| Alzheimer_S_Disease
    CHI3L1(["CHI3L1"])
    CHI3L1 -->|"encodes"| YKL_40
    CLOCK(["CLOCK"])
    CLOCK -->|"regulates"| YKL_40
    style YKL_40 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (31)

Target	Relation	Type	Str
Astrocytes	expressed_in	cell_type	0.95
Alzheimer'S Disease	biomarker_for	disease	0.95
Alzheimer's Disease	involved_in	disease	0.90
Cerebrospinal Fluid	expressed_in	cell_type	0.90
Aging	correlates_with	process	0.90
neuroinflammation	biomarker_for	disease	0.85
neuroinflammation	activates	disease	0.85
Neuroinflammation	regulates	process	0.85
Alzheimer'S Disease Progression	risk_factor_for	phenotype	0.85
microglia	expressed_in	cell_type	0.75
DAM microglia	expressed_in	cell_type	0.65
astrocytes	expressed_in	cell_type	0.65
oxidative stress response	participates_in	pathway	0.65
neuroinflammation	regulates	disease	0.55
neurons	expressed_in	cell_type	0.55
Alzheimer's disease	associated_with	disease	0.55
ubiquitin-proteasome	participates_in	pathway	0.55
neurotrophin signaling	participates_in	pathway	0.55
ALZHEIMER	regulates	gene	0.50
Alzheimer'S Disease	regulates	disease	0.50
Astrocyte	regulates	cell_type	0.50
disease	regulates	disease	0.50
ALZHEIMER'S	regulates	concept	0.50
aging	activates	phenotype	0.50
CEREBROSPINAL FLUID	activates	concept	0.50
NEUROFILAMENT LIGHT CHAIN	associated_with	protein	0.50
SNAP-25	associated_with	protein	0.50
NEUROGRANIN	associated_with	protein	0.50
SYNUCLEIN	associated_with	concept	0.50
α-SYNUCLEIN	associated_with	concept	0.50

Incoming (22)

Source	Relation	Type	Str
CHI3L1	encodes	gene	0.95
GFAP	biomarker_for	gene	0.75
TNF	biomarker_for	gene	0.65
TREM2	biomarker_for	gene	0.65
GFAP	activates	gene	0.65
G3BP1	regulates	gene	0.55
IL-6	regulates	gene	0.55
C3	activates	gene	0.55
IL-6	activates	gene	0.55
TET2	activates	gene	0.55
TREM2	activates	gene	0.55
BDNF	protects_against	gene	0.55
GDNF	protects_against	gene	0.55
IL-6	biomarker_for	gene	0.55
Neuroinflammation	associated_with	process	0.50
Neuroinflammation	regulates	process	0.50
CLOCK	regulates	gene	0.50
CHI3L1	regulates	protein	0.50
CHI3L1	activates	protein	0.50
CHI3L1	associated_with	protein	0.50
CHI3L1	inhibits	protein	0.50
TREM2	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

YKL-40

Understanding Entity Pages

Summary

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Corticobasal Syndrome (CBS)

Novel Therapy Index

nhp-validation-animal-model

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

CBS/PSP Treatment Rankings

Alzheimer's Disease

TREM2 Mechanism Hub

TREM2 Microglial Signaling Pathway in Neurodegeneration

Huntington's Disease

Pre-symptomatic Conversion Windows in ALS Genetic Risk Carriers

Glia-Neuron Crosstalk in Alzheimer's Disease

Cerebrospinal Fluid (CSF) Biomarkers Overview

Novartis Alzheimer's Disease Phase 2 Trial (NCT07094516)

Liquid Biopsy Diagnostics for Corticobasal Syndrome