OP

The authors evaluate several ALS-associated mutations in OPTN's leucine-zipper d

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

ACSL4-Driven Ferroptotic Priming in Disease-Associated Microglia

Score: 0.891 · alzheimers · 2026-04-02

## Mechanistic Overview ACSL4 (acyl-CoA synthetase long-chain family member 4) catalyzes the esterification of arachido

Optimized Temporal Window for Metabolic Boosting Therapy Determines Success of M

Score: 0.887 · neurodegeneration · 2026-04-16

## Mechanistic Overview The therapeutic hypothesis centers on the critical role of interferon-gamma (IFNγ), encoded by

Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhyth

Score: 0.869 · alzheimers · 2026-04-05

## Mechanistic Overview Parvalbumin-positive (PV+) fast-spiking interneurons in entorhinal cortex layers II–III generat

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Score: 0.865 · alzheimers · 2026-04-05

## Mechanistic Overview Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via direct

Optogenetic restoration of hippocampal gamma oscillations via selective PV inter

Score: 0.865 · alzheimers · 2026-04-07

## Mechanistic Overview Optogenetic restoration of hippocampal gamma oscillations via selective PV interneuron activatio

Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV

Score: 0.865 · molecular-neurobiology · 2026-04-17

## Mechanistic Overview Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV Interneuron-Spe

Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-

Score: 0.863 · alzheimers · 2026-04-07

## Mechanistic Overview Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-gamma coupling a

TYROBP (DAP12) Conditional Antagonism for Early-Stage Neuroprotection

Score: 0.844 · neurodegeneration · 2026-04-16

## Mechanistic Overview TYROBP (DAP12) Conditional Antagonism for Early-Stage Neuroprotection starts from the claim that

miR-155/Interferon-gamma Feedback Loop as a Reversible Molecular Switch for Prot

Score: 0.843 · neurodegeneration · 2026-04-16

## Mechanistic Overview miR-155/Interferon-gamma Feedback Loop as a Reversible Molecular Switch for Protective Microglia

Exposed amyloidogenic segments (β-sheet propensity residues) serve as HSP70 reco

Score: 0.840 · protein-biochemistry · 2026-04-21

## **Molecular Mechanism and Rationale** The recognition of amyloidogenic protein species by the heat shock protein 70

Sequential Iron Chelation (Deferoxamine) and GPX4 Restoration (Sulforaphane) Pre

Score: 0.838 · neurodegeneration · 2026-04-17

## Mechanistic Overview Sequential Iron Chelation (Deferoxamine) and GPX4 Restoration (Sulforaphane) Prevents the Self-A

J-protein co-chaperone system mediates selective autophagy targeting of pathogen

Score: 0.831 · protein-biochemistry · 2026-04-28

**Molecular Mechanism and Rationale** The J-protein co-chaperone system functions as a critical autophagy adapter mecha

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Score: 0.827 · alzheimers · 2026-04-16

## Mechanistic Overview Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via glymph

Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 Proteinopathy Neuro

Score: 0.824 · neurodegeneration · 2026-04-05

## Mechanistic Overview Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 Proteinopathy Neuroinflammation in