entity

OP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

30Hypotheses

30Analyses

7Outgoing

0Incoming

Wiki Pages (18)

Knowledge base pages for this entity

Canonical Page

Outgoing (7)

Target	Relation	Type	Str
ESR1	modulates	gene	0.90
endocrine signaling	associated_with	pathway	0.90
Estrogen	modulates	receptor	0.90
Endocrine System	associated_with	process	0.90
chronic kidney disease	causes	disease	0.88
TNF	binds_to	protein	0.85
Breast Cancer	risk_factor_for	disease	0.85

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound to restore hippo	0.709	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II SST interneurons to block t	0.697	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II SST interneur	0.697	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound with 40Hz gamma	0.689	Alzheimer's disease	Circuit-level neural dynamics in neurode
H2: Indole-3-Propionate (IPA) as the Actual Neuroprotective	0.675	neurodegeneration	How does engineered C. butyricum cross t

Closed-loop tACS targeting EC-II PV interneurons to suppress	0.670	Alzheimer's disease	Circuit-level neural dynamics in neurode
Transcriptional Autophagy-Lysosome Coupling	0.665	neurodegeneration	Autophagy-lysosome pathway convergence a
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro	0.662	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Closed-loop tACS targeting EC-II parvalbumin interneurons to	0.660	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial alternating current stimulation to	0.639	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop optogenetic targeting PV interneurons to restore	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.625	Alzheimer's disease	Circuit-level neural dynamics in neurode
APOE-Dependent Autophagy Restoration	0.615	neurodegeneration	Mechanistic role of APOE in neurodegener
Closed-loop focused ultrasound targeting CA1 PV interneurons	0.614	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.614	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.612	Alzheimer's disease	Circuit-level neural dynamics in neurode
STING Antagonism Prevents Acute-to-Chronic Neuroinflammation	0.605	neuroinflammation	What molecular mechanisms drive the tran
Microglial AIM2 Inflammasome as the Primary Driver of TDP-43	0.601	neurodegeneration	What are the mechanisms by which gut mic
IL-10-Producing B10 Cells Establish AQP4-Specific Peripheral	0.601	neuroinflammation	How do B cells mechanistically orchestra
C3aR Blockade Disrupts the Microglial-Astrocyte Feedforward	0.596	neuroinflammation	What molecular mechanisms determine whet
H7: Enteric Nervous System Alpha-Synuclein Propagation Block	0.595	neurodegeneration	How does engineered C. butyricum cross t
TREM2 Agonism to Reprogram Infiltrated Monocytes Toward Neur	0.584	neurodegeneration	What are the specific molecular mechanis
Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re	0.581	neurodegeneration	What are the mechanisms by which gut mic
DAPK1 Inhibition as Dual-Mechanism Neuroprotection Against T	0.579	neurodegeneration	Should microtubule-stabilizing drugs be
Closed-loop tACS targeting EC-II PV interneurons to enhance	0.578	Alzheimer's disease	Circuit-level neural dynamics in neurode
Interneuron SYNGAP1 Deficiency Disrupts Cortical Circuit Ass	0.576	neurodevelopment	How does SYNGAP1, a 'synaptic' protein,
Closed-loop focused ultrasound targeting EC-II PV interneuro	0.568	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.566	Alzheimer's disease	Circuit-level neural dynamics in neurode

Mentioning Analyses (30)

Scientific analyses that reference this entity

Does APOE4 drive tau propagation

neurodegeneration | 2026-04-16 | 0 hypotheses

Does APOE4 drive tau propagation

neurodegeneration | 2026-04-15 | 0 hypotheses

What are the specific molecular determinants that govern tau strain selection du

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.636

How do synthetic EVs achieve brain-specific targeting while avoiding reticuloend

drug delivery | 2026-04-15 | 0 hypotheses

What determines the GPX4/ACSL4 balance that switches microglia from protective t

immunology | 2026-04-15 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Hepatocyte FoxO1 Deficiency Protects From Liver Fibrosis via Reducing Inflammati [PMID:37678798]	Pan Q, Gao M, Kim D, Ai W, Yang W, Jiang	Cell Mol Gastroenterol Hepatol	2024	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
Cinobufagin induces FOXO1-regulated apoptosis, proliferation, migration, and inv [PMID:35176466]	Zhang L, Liang B, Xu H, Gong Y, Hu W, Ji	J Ethnopharmacol	2022	1
Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK [PMID:31693892]	Wang Y, An H, Liu T, Qin C, Sesaki H, Gu	Cell Rep	2019	1
AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking Sy [PMID:30057310]	Song X, Zhu S, Chen P, Hou W, Wen Q, Liu	Curr Biol	2018	1
Obestatin controls the ubiquitin-proteasome and autophagy-lysosome systems in gl [PMID:28675664]	Cid-Díaz T, Santos-Zas I, González-Sánch	J Cachexia Sarcopenia Muscle	2017	1
PTEN loss drives B7H3 upregulation via the mTORC2/FOXO/c-Myc axis to promote tum [PMID:41920736]	Wang Z, Jin N, Li X, Ma X, Feng Y, Yin K	Cell reports	2026	0
Mammalian lipophagy: process and function. [PMID:41681129]	Zhao R, Dai E, Kang R, Liu J, Klionsky D	Autophagy	2026	0
TAZ alleviates ischemic stroke injury by activating Foxo1: Usp1-mediated deubiqu [PMID:41921828]	["Xin Y", "Sun Y", "Pan E", "Li M", "Che	Free radical biology & medicin	2026	0
Combining network pharmacology and multi-omics reveals the role of Shengdihuang- [PMID:41655545]	Cao X, Shang Y, Qu M, Kang Q, Xu Y et al	Phytomedicine	2026	0
A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling an [PMID:41718717]	Golec DP, Gazzinelli-Guimaraes PH, Chaus	J Exp Med	2026	0
Comparative transcriptomics of adherent and suspension chicken fibroblast cell l [PMID:41763754]	Contreras EJ, Nagarajan A, Bromberg BH,	Food Res Int	2026	0
FOXO1 transcription factor modulates airway epithelial responses to viral infect [PMID:41931532]	Daniel NM, Mann-Nüttel R, Shrestha Palik	PLoS One	2026	0
Clinical and immunological significance of FOXO1 as a biomarker of improved resp [PMID:41935603]	Du L, Wang J, Wang Y, Wang H, Xu X et al	Eur J Pharmacol	2026	0
Metformin attenuates TBHP-induced oxidative injury in human lens epithelial cell [PMID:41945556]	Yan Z, Chi W, Yan Z, Wang H	PLoS One	2026	0
Ponatinib inhibits LCK and PI3K signaling and promotes CD8(+) T stem cell memory [PMID:41946709]	Okuhiro Y, Ito S, Watanabe K, Yan Y, Kum	Nat Commun	2026	0
Loss of FoxO in skeletal muscle leads to disrupted muscle metabolism and exacerb [PMID:41950099]	Oyabu M, Sakaue M, Kubo A, Yoshioka K, K	Proc Natl Acad Sci U S A	2026	0
The deubiquitinase activity of CYLD is required for B cell differentiation. [PMID:41951576]	Pseftogas A, Bordini J, Gavriilidis G, F	Cell Death Dis	2026	0
Effects of Vitamin A Restriction on Carcass Characteristics, Antioxidant Capacit [PMID:41856090]	Zhang X, Zhang C, Song J, Bai J, Hao B,	Animal bioscience	2026	0
Transcriptomic identification of CREB1 and FOXO1 activation in neuregulin-1-medi [PMID:41907189]	Bennett KR, Surles-Zeigler MC, Augello C	Frontiers in molecular neurosc	2026	0

OP

Understanding Entity Pages

Wiki Pages (18)

18F-OP-801 Ashvattha Neuroinflammation PET Imaging Trial

Device Therapies Comparison for CBS/PSP

Blood-Brain Barrier Dysfunction in Neurodegeneration

rapamycin-tauopathy

Metabolic-Energetic Restoration: GLP-1 + TFEB Activator Combination

Aché Laboratórios

ARC-IM Adaptive Neurostimulation for Parkinson's Disease

PD Biomarker-to-Mechanism Mapping

Deep Brain Stimulation in Corticobasal Syndrome

Deep Brain Stimulation

TGF-β/BMP Signaling Pathway in Neurodegeneration

Anesthesia Choice in STN-DBS for Parkinson's Disease (NCT05550714)

Deep Brain Stimulation in Corticobasal Syndrome

A Placebo-Controlled, Double-Blind, Parallel-Group, 18-Month Study With an Op... (NCT03887455)

BMP7 Gene (Bone Morphogenetic Protein 7)

Red Nucleus Neurons

Deep Brain Stimulation for Parkinson's Disease

Synapsin1 Protein

Outgoing (7)

Incoming (0)

Targeting Hypotheses (30)

Mentioning Analyses (30)

Does APOE4 drive tau propagation

Does APOE4 drive tau propagation

What are the specific molecular determinants that govern tau strain selection du

How do synthetic EVs achieve brain-specific targeting while avoiding reticuloend

What determines the GPX4/ACSL4 balance that switches microglia from protective t

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

What is the temporal sequence of TREM2 signaling transition from protective to i

What are the precise temporal dynamics of astrocyte ketone production decline du

Should microtubule-stabilizing drugs be reconsidered as therapeutic targets for

What are the physiological functions of BACE1 beyond APP processing that could c

What upstream mechanisms trigger p53 activation specifically in response to poly

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

What molecular mechanisms link elevated sphingomyelin synthase activity to incre

What molecular mechanisms explain how apoE promotes cerebral amyloid angiopathy

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

What molecular mechanisms enable Gal3 to enhance tau fibrillation upon binding t

What molecular mechanisms drive the transition from acute to persistent neuroinf

Why does autophagy inhibition improve neuronal survival when autophagy is typica

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

Why is TYROBP deficiency neuroprotective when TYROBP is an adapter for multiple

Does clusterin exacerbate or protect against neuronal death in neurodegeneration

What specific molecular mechanisms link APOE4 to cholesterol dysregulation in ol

How does pericyte senescence mechanistically promote glioma cell growth and inva

What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effe

What are the specific circulating factors in exercise-conditioned plasma that me

What genetic risk factors predispose individuals to developing CTE following rep

Why do p300/CBP inhibitors reduce both AD incidence and clinically diagnosed TBI

How does FUS loss-of-function in TAZ regulation contribute to ALS/FTD pathogenes

Related Papers (20)