gene 1,470 words KG: OPRM1 2026-03-24
kind:genesection:genesstate:published
Contents

OPRM1 — Mu-Opioid Receptor

🧬 Gene Info
Gene SymbolOPRM1
Full NameMu-Opioid Receptor
Protein TypeProtein
Functionis a G protein-coupled receptor (GPCR) primarily known for its role in pain modulation, reward processing, and opioid drug responses[@minami1995].
Pathwaysautophagy pathway
UniProt IDSearch UniProt
GeneCardsOPRM1
Human Protein AtlasOPRM1
LayerComponents
Outer segment layerPhotoreceptor outer segments
Outer nuclear layerPhot photoreceptor cell bodies
Outer plexiform layerPhotoreceptor synapses
Inner nuclear layerBipolar, horizontal, amacrine cells
Ganglion cell layerGanglion cell axons
FeatureRods
Associated DiseasesAddiction, Alzheimer, Alzheimer'S Disease, Anxiety, Dementia
InteractionsOPRD1, GENES, PER, BDNF, DRD2, DRD4
KG Connections102 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (11)

Noradrenergic-Tau Propagation Blockade
Score: 0.51
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (13)

Alzheimer Indonesia
institution · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with
CYP3A4 — Cytochrome P450 3A4
gene · KG edge: associated_with
CYP2D6 — Cytochrome P450 2D6
gene · KG edge: associated_with
COMT Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

OPRM1 associated_with SLC30A8
OPRM1 associated_with COMT
OPRM1 associated_with NBEA
OPRM1 associated_with HTR2C
OPRM1 associated_with ADRA2A
OPRM1 associated_with BCHE
OPRM1 associated_with SLC6A2
OPRM1 associated_with SLC6A3
OPRM1 associated_with ABCB1
OPRM1 associated_with SLC6A4