protein 1,013 words KG: CHOP 2026-03-29
kind:proteinsection:proteinsstate:publishedkind:redirect
Contents

CHOP Protein

🔬 Protein Info
Gene SymbolCHOP
Full NameCHOP
Chromosome12q13.12
Protein TypeProtein
Functionis a leucine zipper transcription factor that functions as a critical regulator of cellular stress responses, particularly during endoplasmic reticulum (ER) stress and the unfolded protein response...
PathwaysApoptosis, Epigenetic, Er Stress, Ferroptosis, Glycolysis
UniProt IDSearch UniProt
GeneCardsCHOP
Human Protein AtlasCHOP
Associated DiseasesAD, ALI, ALS, Alzheimer, Cancer
Known Drugs/Compoundsrapamycin
InteractionsBECN1, PTEN, DDIT3, NBR1, EMD, MAPK8
KG Connections915 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Neuronal Integrated Stress Response Modulation
Score: 0.45
Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy
Score: 0.43
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Senescence-Activated NAD+ Depletion Rescue
Score: 0.60

Related Analyses (20)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived

Related Experiments (2)

Proposed experiment from debate on TDP-43 undergoes liquid-l
falsification · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (7)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: interacts_with
AMBRA1 Gene
gene · KG edge: activates
ALDH1L1
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

CHOP activates CTSD
CHOP activates DDIT3
CHOP activates DISC1
CHOP activates DNM1L
CHOP activates DRP1
CHOP activates EIF2AK3
CHOP activates EIF2S1
CHOP activates EMD
CHOP activates EPAS1
CHOP activates ERN1