gene

P2RY14

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P2RY14: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections
0Hypotheses
0Analyses
26Outgoing
15Incoming
0Experiments

Summary

P2RY14 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, therapeutic target, targets. Associated with Ms, Respiratory Disease, Tumor. Connected to 27 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolP2RY14
Full NamePurinergic Receptor P2Y14
AliasesPage for P2RY14 Gene
Chromosome3q25.1
Protein TypeReceptor
Functionencodes a G-protein coupled receptor that responds to UDP-sugars (particularly UDP-glucose, UDP-galactose, and UDP-N-acetylglucosamine) and mediates immune and inflammatory responses.
Primary Expressionimmune tissues and regulates:
Amino Acids336 aa
PathwaysPI3K
UniProt IDQ9HC97
NCBI Gene ID9939
GeneCardsP2RY14
Human Protein AtlasP2RY14
N-terminusExtracellular, glycosylation sites
Transmembrane domains7 α-helices crossing the membrane
Associated Diseasesneurodegeneration
KG Connections41 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: P2RY14 — AlphaFold Q9HC97 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

P2RY14 Gene - Purinergic Receptor P2Y14

gene · 1217 words

P2Y14 Receptor Antagonists for Neurodegeneration

therapeutic · 612 words

Genes

index · 271 words

Pathway Diagram

graph TD
    P2RY14["<b>P2RY14</b>"]
    Ms{"Ms"}
    P2RY14 -->|"expressed in"| Ms
    Tumor{"Tumor"}
    P2RY14 -->|"expressed in"| Tumor
    P2RY1["P2RY1"]
    P2RY14 -->|"therapeutic target"| P2RY1
    P2RX7["P2RX7"]
    P2RY14 -->|"therapeutic target"| P2RX7
    MMP9["MMP9"]
    P2RY14 -->|"expressed in"| MMP9
    FOS["FOS"]
    P2RY14 -->|"expressed in"| FOS
    TAC1["TAC1"]
    P2RY14 -->|"expressed in"| TAC1
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    P2RY14 -->|"expressed in"| IMMUNE_INFILTRATION
    CHONDROCYTE_APOPTOSIS["CHONDROCYTE APOPTOSIS"]
    P2RY14 -->|"expressed in"| CHONDROCYTE_APOPTOSIS
    APOPTOSIS["APOPTOSIS"]
    P2RY14 -->|"expressed in"| APOPTOSIS
    SPP1["SPP1"]
    P2RY14 -->|"expressed in"| SPP1
    Apoptosis(["Apoptosis"])
    P2RY14 -->|"expressed in"| Apoptosis
    P2RX1["P2RX1"]
    P2RX1 -->|"therapeutic target"| P2RY14
    P2RX4["P2RX4"]
    P2RX4 -->|"therapeutic target"| P2RY14
    P2RX7 -->|"therapeutic target"| P2RY14
    P2RY1 -->|"therapeutic target"| P2RY14
    PLIN1["PLIN1"]
    PLIN1 -->|"expressed in"| P2RY14
    IGF1["IGF1"]
    IGF1 -->|"expressed in"| P2RY14
    ATP["ATP"]
    ATP -->|"expressed in"| P2RY14
    P2RY1 -->|"expressed in"| P2RY14
    style P2RY14 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (26)

TargetRelationTypeStr
LUNG TISSUEexpressed_inentity0.95
THERAPEUTIC_TARGETtherapeutic_targetentity0.90
Respiratory Diseasetargetsdisease0.75
Msexpressed_indisease0.65
Tumorexpressed_indisease0.65

Incoming (15)

SourceRelationTypeStr
P2RX1expressed_inentity0.60
P2RX4expressed_inentity0.60
P2RX7expressed_inentity0.60
P2RX1therapeutic_targetgene0.60
P2RX4therapeutic_targetgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found