gene

IGF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IGF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

459Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

IGF1 is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with Aging, Als, Alzheimer. Connected to 242 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IGF1
Chromosome	12q23.2
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	7.6 kDa
Amino Acids	70 aa
Exons	6
Pathways	PI3K, MAPK
Ensembl ID	ENSG00000117471
GeneCards	IGF1
Human Protein Atlas	IGF1
Class 1 transcripts	Include exon 1, encode the classic IGF-1A and IGF-1B isoforms
Class 2 transcripts	Include exon 2, produce variants with different N-terminal signal peptides
Ea isoform	The predominant brain isoform
Eb isoform	Less abundant, alternative splicing
Associated Diseases	ALS, Alzheimer, Ms
Known Drugs/Compounds	rapamycin
Interactions	PI3K, PDGFRB, AKT, IGF1R, EGR1, AURKA
KG Connections	459 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    IGF1["IGF1"]
    IGF1 -->|"activates"| Ms["Ms"]
    IGF1 -->|"activates"| Fibrosis["Fibrosis"]
    IGF1 -->|"activates"| Ischemia["Ischemia"]
    IGF1 -->|"inhibits"| Als["Als"]
    IGF1 -->|"target for"| Cancer["Cancer"]
    IGF1 -->|"target for"| Carcinoma["Carcinoma"]
    IGF1 -->|"target for"| Tumor["Tumor"]
    PDGFRB["PDGFRB"] -->|"activates"| IGF1
    IGF1R["IGF1R"] -->|"activates"| IGF1
    EGR1["EGR1"] -->|"activates"| IGF1
    EGF["EGF"] -->|"activates"| IGF1
    AKT["AKT"] -->|"activates"| IGF1
    PON1["PON1"] -->|"target for"| IGF1
    PLIN1["PLIN1"] -->|"expressed in"| IGF1
    CD44["CD44"] -.biomarker for.-> IGF1
    RELB["RELB"] -->|"interacts"| IGF1

Outgoing (312)

Target	Relation	Type	Str
Oligodendrocyte	promotes	cell_type	0.88
Myogenesis	promotes	process	0.85
myogenesis	promotes	process	0.85
senescence	regulates	process	0.85
Synaptic Plasticity	promotes	process	0.85
Cardiovascular Health	regulates	biological_process	0.80
Als	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75
Cancer	regulates	disease	0.75
AKT	regulates	gene	0.70
CANCER	regulates	gene	0.70
MICROGLIA	regulates	cell_type	0.70
MAPK signaling	participates_in	pathway	0.70
TREM2	associated_with	gene	0.65
PI3K	increases	gene	0.65
Ms	activates	disease	0.65
Fibrosis	activates	disease	0.65
Ischemia	activates	disease	0.65
Als	inhibits	disease	0.65
STROKE	associated_with	gene	0.65
Ms	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Atherosclerosis	interacts_with	disease	0.65
Ms	associated_with	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	interacts_with	disease	0.65
Als	expressed_in	disease	0.65
Ms	regulates	disease	0.65
Hypertension	regulates	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65
Fibrosis	biomarker_for	disease	0.65
Diabetes	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Inflammation	expressed_in	disease	0.65
Aging	inhibits	disease	0.65
Huntington	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Longevity	regulates	disease	0.65
Aging	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Inflammation	activates	disease	0.65
Senescence	activates	disease	0.65
Obesity	activates	disease	0.65

Incoming (147)

Source	Relation	Type	Str
Exercise	upregulates	process	0.85
IL30	inhibits	gene	0.80
GENES	activates	gene	0.70
MICROGLIA	exacerbates	cell_type	0.70
MICROGLIA	treats	cell_type	0.70
AKT	increases	gene	0.65
FIBROSIS	regulates	disease	0.65
HIPPOCAMPUS	activates	brain_region	0.65
PDGFRB	activates	gene	0.60
IGF1R	activates	gene	0.60
EGR1	activates	gene	0.60
EGF	activates	gene	0.60
AKT	activates	gene	0.60
AKT	associated_with	gene	0.60
PON1	therapeutic_target	gene	0.60
HMOX1	associated_with	gene	0.60
PLIN1	expressed_in	gene	0.60
CD44	biomarker_for	gene	0.60
RELB	interacts_with	gene	0.60
MAP2K1	associated_with	gene	0.60
PI3K	activates	gene	0.60
PLIN2	activates	gene	0.60
FOS	activates	gene	0.60
STAT3	activates	gene	0.60
BDNF	activates	gene	0.60
MMP2	inhibits	gene	0.60
ARC	activates	gene	0.60
PTEN	inhibits	gene	0.60
IL6	activates	gene	0.60
MMP9	inhibits	gene	0.60
NGF	activates	gene	0.60
HSP90B1	activates	gene	0.60
PI3K	regulates	gene	0.60
EGFR	activates	gene	0.60
HSPA4	activates	gene	0.60
FOXO1	activates	gene	0.60
HSP90AA1	activates	gene	0.60
PRKACB	activates	gene	0.60
PIK3R1	activates	gene	0.60
OVERVIEW	interacts_with	gene	0.60
PI3K	associated_with	gene	0.60
IGF1R	associated_with	gene	0.60
CASPASE3	activates	gene	0.60
HSP90AA1	associated_with	gene	0.60
AKT1	associated_with	gene	0.60
FOXO1	associated_with	gene	0.60
PIK3CG	associated_with	gene	0.60
BAX	activates	gene	0.60
SRC	activates	gene	0.60
ERK1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IGF1

Understanding Entity Pages

Summary

Wiki Pages (21)

IGF1 Gene

Parkinson's Disease

Neuroresilience Mechanisms and Evidence

Alzheimer's Disease

Epigenetic Alterations in Alzheimer's Disease

Growth Factor Therapeutics: Investment Landscape Analysis

IGF-1 Signaling Pathway in Neurodegeneration

Neurogenesis and Neurodegeneration

IGF2 Protein (Insulin-like Growth Factor 2)

Neuroprotective Microglia

Semaglutide (Wegovy/Ozempic) for Neurodegenerative Diseases

Neurogenesis Disease Comparison

VPS51 Gene

metabolic-syndrome-parkinsons-axis

hpgv-parkinsons

CDKN1B — Cyclin-Dependent Kinase Inhibitor 1B

sall1

VPS35/Retromer Stabilizers for Parkinson's Disease

AKT1 Protein