Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PLURIPOTENCY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | PLURIPOTENCY |
| Related Pathways | PI3K_AKT_MTOR |
Knowledge base pages for this entity
graph TD
PLURIPOTENCY["PLURIPOTENCY"]
OCT4["OCT4"] -->|"activates"| PLURIPOTENCY
SOX2["SOX2"] -->|"activates"| PLURIPOTENCY
KLF4["KLF4"] -->|"activates"| PLURIPOTENCY
C_MYC["C-MYC"] -->|"activates"| PLURIPOTENCY
PI3K_AKT_mTOR["PI3K/AKT/mTOR"] -->|"regulates"| PLURIPOTENCY
POU5F1["POU5F1"] -->|"involved_in"| PLURIPOTENCY
NANOG["NANOG"] -->|"involved_in"| PLURIPOTENCY| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| SOX2 | associated_with | gene | 0.95 |
| OCT4 | activates | gene | 0.90 |
| SOX2 | activates | gene | 0.90 |
| KLF4 | activates | gene | 0.90 |
| SOX2 | involved_in | gene | 0.90 |
| OCT4 | associated_with | gene | 0.90 |
| KLF4 | associated_with | gene | 0.90 |
| POU5F1 | involved_in | gene | 0.90 |
| OCT4 | promotes | gene | 0.90 |
| SOX2 | promotes | gene | 0.90 |
| KLF4 | promotes | gene | 0.90 |
| MYC | promotes | gene | 0.90 |
| C-MYC | activates | gene | 0.90 |
| PI3K/AKT/mTOR | regulates | pathway | 0.90 |
| C-MYC | associated_with | gene | 0.90 |
| NANOG | involved_in | gene | 0.90 |
| PI3K_AKT_MTOR | regulates | pathway | 0.64 |
| AKT | inhibits | gene | 0.60 |
| SOX2 | regulates | gene | 0.60 |
| PI3K | regulates | gene | 0.60 |
| CYCLIN B1 | regulates | gene | 0.60 |
| CDK1 | regulates | gene | 0.60 |
| PDK1 | regulates | gene | 0.60 |
| AKT | regulates | gene | 0.60 |
| CANCER | inhibits | gene | 0.60 |
| Tumor | inhibits | disease | 0.60 |
| Cancer | inhibits | disease | 0.60 |
| Carcinoma | inhibits | disease | 0.60 |
| ERK | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity