PQBP1

Understanding Entity Pages

This page aggregates everything SciDEX knows about PQBP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

PQBP1 encodes a nuclear protein that binds polyglutamine-expanded proteins and regulates transcription. Mutations cause X-linked mental retardation; dysregulation implicated in ALS, HD, and SCAs.

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graph TD
    PQBP1["PQBP1"]
    CGAS["CGAS"]
    PQBP1 -->|"activates"| CGAS
    Inflammation{"Inflammation"}
    PQBP1 -->|"activates"| Inflammation
    Infection{"Infection"}
    PQBP1 -->|"activates"| Infection
    Als{"Als"}
    PQBP1 -->|"associated_with"| Als
    Neurodegeneration{"Neurodegeneration"}
    PQBP1 -->|"activates"| Neurodegeneration
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
    PQBP1 -->|"activates"| NEURODEGENERATIVE_DISORDERS
    INFLAMMATION["INFLAMMATION"]
    PQBP1 -->|"activates"| INFLAMMATION
    BRAIN_INFLAMMATION["BRAIN INFLAMMATION"]
    PQBP1 -->|"activates"| BRAIN_INFLAMMATION
    GENES["GENES"]
    PQBP1 -->|"activates"| GENES
    STING["STING"]
    PQBP1 -->|"activates"| STING
    CGAS_STING["CGAS-STING"]
    PQBP1 -->|"activates"| CGAS_STING
    MICROGLIA["MICROGLIA"]
    PQBP1 -->|"activates"| MICROGLIA
    Immune_Response(["Immune Response"])
    PQBP1 -->|"activates"| Immune_Response
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"activates"| PQBP1
    TAU["TAU"]
    TAU -->|"activates"| PQBP1