Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PRDM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PRDM2 is a protein involved in neurodegeneration research. Key relationships include: expressed in, contributes to, implicated in. Associated with Cancer, Colorectal Cancer, Tumor. Connected to 15 entities in the SciDEX knowledge graph.
| Gene Symbol | PRDM2 |
| Full Name | PRDI-BF1 and RIZ Homology Domain Containing 2 |
| Protein Family | PRDM Family |
| Protein Type | Transferase |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | Nucleus |
| Molecular Weight | 59 kDa |
| UniProt ID | Q15691 |
| GeneCards | PRDM2 |
| Human Protein Atlas | PRDM2 |
| Alzheimer's Disease | Altered expression and function contributes to epigenetic dysregulation of neuronal survival genes |
| Parkinson's Disease | May affect dopaminergic neuron survival through transcriptional mechanisms |
| Huntington's Disease | Involved in transcriptional dysregulation caused by mutant huntingtin protein |
| Associated Diseases | neurodegeneration |
| KG Connections | 14 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PRDM2["<b>PRDM2</b>"]
Colorectal_Cancer{"Colorectal Cancer"}
PRDM2 -->|"expressed_in"| Colorectal_Cancer
Cancer{"Cancer"}
PRDM2 -->|"expressed_in"| Cancer
Tumor{"Tumor"}
PRDM2 -->|"expressed_in"| Tumor
DNA(["DNA"])
PRDM2 -->|"expressed_in"| DNA
P53(["P53"])
PRDM2 -->|"expressed_in"| P53
CANCER(["CANCER"])
PRDM2 -->|"expressed_in"| CANCER
ASH1L(["ASH1L"])
ASH1L -->|"contributes_to"| PRDM2
ARID1A(["ARID1A"])
ARID1A -->|"contributes_to"| PRDM2
PI3K(["PI3K"])
PI3K -->|"expressed_in"| PRDM2
style PRDM2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7| Target | Relation | Type | Str |
|---|---|---|---|
| Colorectal Cancer | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| EP300 | contributes_to | gene | 0.60 |
| DNA | expressed_in | gene | 0.60 |
| P53 | expressed_in | gene | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| GENES | contributes_to | gene | 0.60 |
| Mapk | expressed_in | pathway | 0.60 |
| Mismatch Repair | expressed_in | pathway | 0.60 |
| Wnt | expressed_in | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||