protein

PRDM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRDM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections
0Hypotheses
0Analyses
11Outgoing
3Incoming

Summary

PRDM2 is a protein involved in neurodegeneration research. Key relationships include: expressed in, contributes to, implicated in. Associated with Cancer, Colorectal Cancer, Tumor. Connected to 15 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolPRDM2
Full NamePRDI-BF1 and RIZ Homology Domain Containing 2
Protein FamilyPRDM Family
Protein TypeTransferase
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular LocalizationNucleus
Molecular Weight59 kDa
UniProt IDQ15691
GeneCardsPRDM2
Human Protein AtlasPRDM2
Alzheimer's DiseaseAltered expression and function contributes to epigenetic dysregulation of neuronal survival genes
Parkinson's DiseaseMay affect dopaminergic neuron survival through transcriptional mechanisms
Huntington's DiseaseInvolved in transcriptional dysregulation caused by mutant huntingtin protein
Associated Diseasesneurodegeneration
KG Connections14 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: PRDM2 — AlphaFold Q15691 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

PRDM2 — PR/SET domain 2

gene · 587 words

Epigenetic Alterations in Alzheimer's Disease

pathway · 2868 words

Epigenetic Regulation

mechanism · 2116 words

ASH1L

gene · 988 words

PRDM2 Histone Methyltransferase (PRDM2)

protein · 505 words

Proteins

index · 296 words

Pathway Diagram

graph TD
    PRDM2["<b>PRDM2</b>"]
    Colorectal_Cancer{"Colorectal Cancer"}
    PRDM2 -->|"expressed_in"| Colorectal_Cancer
    Cancer{"Cancer"}
    PRDM2 -->|"expressed_in"| Cancer
    Tumor{"Tumor"}
    PRDM2 -->|"expressed_in"| Tumor
    DNA(["DNA"])
    PRDM2 -->|"expressed_in"| DNA
    P53(["P53"])
    PRDM2 -->|"expressed_in"| P53
    CANCER(["CANCER"])
    PRDM2 -->|"expressed_in"| CANCER
    ASH1L(["ASH1L"])
    ASH1L -->|"contributes_to"| PRDM2
    ARID1A(["ARID1A"])
    ARID1A -->|"contributes_to"| PRDM2
    PI3K(["PI3K"])
    PI3K -->|"expressed_in"| PRDM2
    style PRDM2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (11)

TargetRelationTypeStr
Colorectal Cancerexpressed_indisease0.65
Cancerexpressed_indisease0.65
Tumorexpressed_indisease0.65
EP300contributes_togene0.60
DNAexpressed_ingene0.60

Incoming (3)

SourceRelationTypeStr
ASH1Lcontributes_togene0.60
ARID1Acontributes_togene0.60
PI3Kexpressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found