Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Mismatch Repair: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | Mismatch Repair |
| Key Genes/Proteins | CANCER, P53, DNA, POLE |
| Related Diseases | Cancer, Als, Tumor, Carcinoma |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
CANCER["CANCER"] -->|"associated"| Mismatch_Repair["Mismatch Repair"]
Cancer["Cancer"] -->|"associated"| Mismatch_Repair["Mismatch Repair"]
P53["P53"] -->|"associated"| Mismatch_Repair["Mismatch Repair"]
Als["Als"] -->|"treats"| Mismatch_Repair["Mismatch Repair"]
style Mismatch_Repair fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| CANCER | associated_with | gene | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| P53 | associated_with | gene | 0.90 |
| Als | treats | disease | 0.90 |
| CANCER | therapeutic_target | gene | 0.90 |
| Cancer | therapeutic_target | disease | 0.90 |
| DNA | associated_with | gene | 0.80 |
| POLE | associated_with | gene | 0.80 |
| Tumor | activates | disease | 0.70 |
| Als | activates | disease | 0.70 |
| Als | therapeutic_target | disease | 0.70 |
| DNA | causes | gene | 0.70 |
| CANCER | treats | gene | 0.70 |
| Cancer | treats | disease | 0.70 |
| Carcinoma | treats | disease | 0.70 |
| Colorectal Cancer | associated_with | disease | 0.70 |
| Gastric Cancer | associated_with | disease | 0.70 |
| ASH1L | expressed_in | gene | 0.60 |
| ARID1A | expressed_in | gene | 0.60 |
| PI3K | associated_with | gene | 0.60 |
| PRDM2 | expressed_in | gene | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| EP300 | expressed_in | gene | 0.60 |
| Colorectal Cancer | expressed_in | disease | 0.60 |
| Cancer | expressed_in | disease | 0.60 |
| Tumor | expressed_in | disease | 0.60 |
| ARID1A | treats | gene | 0.60 |
| PI3K | treats | gene | 0.60 |
| L1CAM | treats | gene | 0.60 |
| AKT | treats | gene | 0.60 |
| MTOR | treats | gene | 0.60 |
| Tumor | treats | disease | 0.60 |
| KRAS | associated_with | gene | 0.60 |
| TP53 | associated_with | gene | 0.60 |
| SMAD4 | associated_with | gene | 0.60 |
| APC | associated_with | gene | 0.60 |
| PIK3CA | associated_with | gene | 0.60 |
| OVERVIEW | inhibits | gene | 0.60 |
| Colorectal Cancer | inhibits | disease | 0.60 |
| HDAC6 | regulates | gene | 0.60 |
| DNA | regulates | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| BRCA1 | regulates | gene | 0.60 |
| Cancer | regulates | disease | 0.60 |
| Als | regulates | disease | 0.60 |
| TP53 | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| RHOA | activates | gene | 0.60 |
| CDH1 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Temporal CAG Repeat Stabilization via CRISPR-Mediated DNA Mi | 0.511 | neurodegeneration | CRISPR-based therapeutic approaches for |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Mismatch repair MLH complexes make distinct contributions to post-replicative mi [PMID:41648604] | Casazza KM, Williams GM, Johengen L, Kel | bioRxiv | 2026 | 0 |