Entity Detail ā Knowledge Graph Node
This page aggregates everything SciDEX knows about PRKCG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PRKCG is a gene implicated in neurodegeneration research. Key relationships include: associated with, causes, expressed in. Associated with Ataxia, Neurodegeneration, Spinocerebellar Ataxia. Connected to 13 entities in the SciDEX knowledge graph.
| Gene Symbol | PRKCG |
| Full Name | Protein Kinase C Gamma |
| Chromosome | 19q13.42 |
| Function | is a key mediator of the diacylglycerol (DAG) signaling pathway. |
| Primary Expression | Neuron-specific |
| Molecular Weight | 89 kDa |
| Amino Acids | 697 aa |
| Exons | 17 |
| UniProt ID | [P05129](https://www.uniprot.org/uniprot/P05129) |
| Ensembl ID | ENSG00000156508 |
| OMIM | 176980 |
| GeneCards | PRKCG |
| Human Protein Atlas | PRKCG |
| Associated Diseases | Ataxia, Neurodegeneration, Spinocerebellar Ataxia |
| Interactions | ERK1 |
| KG Connections | 34 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PRKCG["<b>PRKCG</b>"]
Neurodegeneration{"Neurodegeneration"}
PRKCG -->|"associated with"| Neurodegeneration
Ataxia{"Ataxia"}
PRKCG -->|"associated with"| Ataxia
PRKCG -->|"regulates"| Neurodegeneration
Spinocerebellar_Ataxia{"Spinocerebellar Ataxia"}
PRKCG -->|"causes"| Spinocerebellar_Ataxia
PRKCG -->|"causes"| Neurodegeneration
PKC["PKC"]
PRKCG -->|"associated with"| PKC
NEURODEGENERATION["NEURODEGENERATION"]
PRKCG -->|"causes"| NEURODEGENERATION
GENES["GENES"]
PRKCG -->|"causes"| GENES
AND["AND"]
PRKCG -->|"associated with"| AND
Purkinje_Cell["Purkinje Cell"]
PRKCG -->|"expressed in"| Purkinje_Cell
Neuron["Neuron"]
PRKCG -->|"expressed in"| Neuron
neurodegeneration["neurodegeneration"]
PRKCG -->|"implicated in"| neurodegeneration
PKC -->|"associated with"| PRKCG
GENES -->|"associated with"| PRKCG
style PRKCG fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Fragile X-Associated Tremor/Ataxia Syndrome | modulates | disease | 0.90 |
| Fragile X-Associated Tremor/Ataxia Syndrome | therapeutic_target | disease | 0.90 |
| Fragile X-associated tremor/ataxia syndrome | modulates | disease | 0.85 |
| Cgg-Associated Neurotoxicity | modulates | mechanism | 0.85 |
| Gabaergic Dysfunction | associated_with | process | 0.85 |
| neurodegeneration | contributes_to | process | 0.80 |
| therapeutic_target | targets | process | 0.80 |
| disease onset | promotes | phenotype | 0.80 |
| Gabaergic Neurons | expressed_in | cell_type | 0.80 |
| Neurodegeneration | associated_with | disease | 0.65 |
| Ataxia | associated_with | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| Spinocerebellar Ataxia | causes | disease | 0.65 |
| Neurodegeneration | causes | disease | 0.65 |
| PKC | associated_with | gene | 0.60 |
| Purkinje | associated_with | cell_type | 0.60 |
| Rb | associated_with | protein | 0.60 |
| NEURODEGENERATION | causes | gene | 0.60 |
| GENES | causes | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| Neuron | associated_with | cell_type | 0.60 |
| App | associated_with | protein | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| Purkinje Cell | expressed_in | cell_type | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| microglia | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||