Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PRKNPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Parkin (encoded by the PRKN gene) is a critically important E3 ubiquitin ligase that plays a central role in mitochondrial quality control through mitophagy.
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| Gene Symbol | PRKNPROTEIN |
| Full Name | Parkin |
| Protein Type | Protein |
| Function | is a critically important E3 ubiquitin ligase that plays a central role in mitochondrial quality control through mitophagy. |
| Subcellular Localization | Parkin family proteins that serves as a scaffold for protein interactions and co |
| UniProt ID | Search UniProt |
| GeneCards | PRKNPROTEIN |
| Human Protein Atlas | PRKNPROTEIN |
| RING0 domain (residues 141-188) | A unique domain found in Parkin family proteins that serves as a scaffold for protein interactions and contributes to the active site architecture. |
| RING1 domain (residues 212-277) | Contains the first RING finger motif that coordinates two zinc ions. This domain interacts with E2 ubiquitin-conjugating enzymes. |
| Associated Diseases | AD, Aging, ALI, Als, Alzheimer |
| Known Drugs/Compounds | dimethyl fumarate, FB231, Fumarate, nicotinamide, rapamycin |
| Interactions | ABCD3, ABP, ACTB, Actin, AIF1, AIFM1 |
| KG Connections | 1622 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PRKNPROTEIN["PRKNPROTEIN"]
neurodegeneration["neurodegeneration"]
PRKNPROTEIN -->|"implicated_in"| neurodegeneration
style PRKNPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PRKNPROTEIN in their description or question text
No additional research found