concept

PABP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PABP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections

0Hypotheses

0Analyses

24Outgoing

14Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	PABP1
Key Genes/Proteins	Eif4B, CHAC2, eIF4B
Related Diseases	Ms, Cancer, Tumor

Wiki Pages (12)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PABP1["PABP1"]
    PABP1 -->|"interacts"| Eif4B["Eif4B"]
    PABP1 -->|"involved_in"| Stress_Granules["Stress Granules"]
    PABP1 -->|"involved_in"| STRESS_GRANULE_FORMATION["STRESS GRANULE FORMATION"]
    PABP1 -->|"interacts"| EIF4B["EIF4B"]
    PABP1 -->|"interacts"| eIF4B["eIF4B"]
    PABP1 -->|"activates"| Ms["Ms"]
    PABP1 -->|"activates"| Cancer["Cancer"]
    PABP1 -->|"activates"| Tumor["Tumor"]
    Hypoxia["Hypoxia"] -->|"modulates"| PABP1
    GENES["GENES"] -->|"activates"| PABP1
    HIF_1_["HIF-1Alpha"] -->|"activates"| PABP1
    CHAC2["CHAC2"] -->|"activates"| PABP1
    EIF4B -->|"activates"| PABP1
    CANCER["CANCER"] -->|"activates"| PABP1
    G3BP1["G3BP1"] -->|"activates"| PABP1
    AND["AND"] -->|"activates"| PABP1

Outgoing (24)

Target	Relation	Type	Str
Eif4B	interacts_with	protein	0.95
Stress Granules	involved_in	process	0.95
Stress Granule Formation	involved_in	process	0.95
STRESS GRANULE FORMATION	involved_in	entity	0.90
EIF4B	interacts_with	entity	0.90
CHAC2	upregulates	gene	0.85
Stress Granules	associated_with	entity	0.80
eIF4B	interacts_with	protein	0.80
Ms	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
AND	activates	gene	0.60
HIF	activates	gene	0.60
G3BP1	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
CHAC2	activates	gene	0.60
EIF4B	activates	gene	0.60
Hif-1	activates	protein	0.60
ferroptosis	participates_in	pathway	0.60
ferroptosis	activates	process	0.60
TIA1	associated_with	gene	0.55
TIA1	interacts_with	gene	0.55
oxidative stress response	participates_in	pathway	0.55

Incoming (14)

Source	Relation	Type	Str
Hypoxia	modulates	process	0.90
Hypoxia	regulates	process	0.90
hypoxia	drives	process	0.90
phase separation	associated_with	process	0.85
GENES	activates	gene	0.60
HIF-1Α	activates	gene	0.60
CHAC2	activates	gene	0.60
EIF4B	activates	gene	0.60
CANCER	activates	gene	0.60
G3BP1	activates	gene	0.60
AND	activates	gene	0.60
HIF	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
G3BP1	interacts_with	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PABP1

Understanding Entity Pages

Wiki Pages (12)

DDX3X Gene

TAR DNA-Binding Protein 43 (TDP-43)

Stress Granules in Neurodegeneration

TIAL1 — TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1

TIA1L (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like)

eef1a1-protein

igf2bp3-protein

IGF2BP2

IGF2BP1

IGF2BP1 Protein