Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about STRESS GRANULE FORMATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | STRESS GRANULE FORMATION |
Knowledge base pages for this entity
graph TD
STRESS_GRANULE_FORMATION["STRESS GRANULE FORMATION"]
STRESS_GRANULE_FORMATION -.protects against.-> Neurodegeneration["Neurodegeneration"]
STRESS_GRANULE_FORMATION -->|"inhibits"| PROTEIN_SYNTHESIS["PROTEIN SYNTHESIS"]
STRESS_GRANULE_FORMATION -->|"inhibits"| Protein_Translation["Protein Translation"]
STRESS_GRANULE_FORMATION -->|"contributes to"| Neuronal_Degeneration["Neuronal Degeneration"]
STRESS_GRANULE_FORMATION -->|"promotes"| cell_survival["cell survival"]
Lysosomal_Damage["Lysosomal Damage"] -->|"causes"| STRESS_GRANULE_FORMATION
PABP1_eIF4B_Complex["PABP1/eIF4B Complex"] -->|"mediates"| STRESS_GRANULE_FORMATION
nsP3["nsP3"] -->|"inhibits"| STRESS_GRANULE_FORMATION
Oxidative_Stress["Oxidative Stress"] -->|"causes"| STRESS_GRANULE_FORMATION
OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"causes"| STRESS_GRANULE_FORMATION
ATG8YLATION["ATG8YLATION"] -->|"regulates"| STRESS_GRANULE_FORMATION
PABP1["PABP1"] -->|"involved_in"| STRESS_GRANULE_FORMATION
EIF4B["EIF4B"] -->|"involved_in"| STRESS_GRANULE_FORMATION| Target | Relation | Type | Str |
|---|---|---|---|
| PROTEIN SYNTHESIS | inhibits | entity | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| LYSOSOMAL DAMAGE | associated_with | entity | 0.95 |
| OXIDATIVE STRESS | causes | entity | 0.90 |
| MAPT | associated_with | entity | 0.90 |
| ATG8YLATION | regulates | entity | 0.90 |
| PABP1 | involved_in | entity | 0.90 |
| EIF4B | involved_in | entity | 0.90 |
| HIF1A | regulates | entity | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||