concept

STRESS GRANULES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STRESS GRANULES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

181Connections

0Hypotheses

7Analyses

14Outgoing

45Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	STRESS GRANULES
Key Genes/Proteins	TDP-43, SIRT1, UBQLN2
Related Diseases	SENESCENCE, AMYOTROPHIC LATERAL SCLEROSIS

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    STRESS_GRANULES["STRESS GRANULES"]
    style STRESS_GRANULES fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    STRESS_GRANULES -->|"involved_in"| Prostate_Cancer["Prostate Cancer"]
    STRESS_GRANULES -->|"modulates"| Senescence["Senescence"]
    STRESS_GRANULES -->|"involved_in"| TDP_43([TDP-43])
    STRESS_GRANULES -->|"mediates"| Cellular_Stress_Response["Cellular Stress Response"]
    STRESS_GRANULES -.->|"inhibits"| Protein_Translation["Protein Translation"]
    STRESS_GRANULES -->|"involved_in"| Glioma["Glioma"]
    STRESS_GRANULES -->|"component_of"| Stress_Granule_Assembly["Stress Granule Assembly"]
    STRESS_GRANULES -->|"activates"| ChaC2_Translation["ChaC2 Translation"]
    STRESS_GRANULES -->|"regulates"| mRNA_Stability["mRNA Stability"]
    PABP1_eIF4B_Complex([PABP1/eIF4B Complex]) -->|"involved_in"| STRESS_GRANULES
    Liquid_Liquid_Phase_Separation["Liquid-Liquid Phase Separation"] -->|"involved_in"| STRESS_GRANULES
    TRIM21([TRIM21]) -->|"regulates"| STRESS_GRANULES
    G3BP1([G3BP1]) -->|"mediates"| STRESS_GRANULES
    Phase_Separation["Phase Separation"] -->|"involved_in"| STRESS_GRANULES

Outgoing (82)

Target	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	entity	0.80
PARKINSON'S DISEASE	associated_with	entity	0.80
GLIOMA	associated_with	entity	0.80
SENESCENCE	interacts_with	entity	0.80
SENESCENCE	regulates	phenotype	0.65
TDP-43	causes	gene	0.65
SIRT1	inhibits	gene	0.65
SIRT1	protects_against	gene	0.65
AMYOTROPHIC LATERAL SCLEROSIS	implicated_in	disease	0.55
NEURONS	implicated_in	cell_type	0.55
IPSC	regulates	concept	0.50
ORGANOIDS	activates	concept	0.50
NUCLEUS	interacts_with	concept	0.50
B CELLS	activates	concept	0.50

Incoming (99)

Source	Relation	Type	Str
TAU	associated_with	entity	0.80
UBQLN2	recruits	gene	0.65
TDP-43	interacts_with	gene	0.65
Autophagy	regulates	process	0.50
G3BP1	regulates	gene	0.50
UBIQUITIN	regulates	protein	0.50
TRIM21	regulates	concept	0.50
Proteins	associated_with	protein	0.50
G3BP1	causes	gene	0.50
cancer	activates	disease	0.50
Glioma	activates	disease	0.50
disease	activates	disease	0.50
Proteins	activates	protein	0.50
mTOR	regulates	entity	0.50
Gastric Cancer	activates	disease	0.50
G3BP1	activates	gene	0.50
CLPP	associated_with	gene	0.50
LONP1	associated_with	gene	0.50
cancer	associated_with	disease	0.50
Prostate Cancer	associated_with	disease	0.50
Drug Resistance	associated_with	pathway	0.50
cancer	interacts_with	disease	0.50
FMRP	activates	protein	0.50
Tdp-43	activates	pathway	0.50
MOTOR NEURONS	activates	concept	0.50
NEURONS	activates	concept	0.50
Neurodegenerative Diseases	associated_with	disease	0.50
Proteins	interacts_with	protein	0.50
disease	associated_with	disease	0.50
NEURODEGENERATIVE DISEASE	associated_with	concept	0.50
ATXN2	regulates	gene	0.50
MOTOR NEURONS	regulates	concept	0.50
NEURONS	regulates	concept	0.50
Tdp-43	associated_with	pathway	0.50
oxidative stress	associated_with	phenotype	0.50
Autophagy	associated_with	process	0.50
HNRNPA2B1	interacts_with	gene	0.50
ELAVL4	activates	gene	0.50
MAPT	activates	gene	0.50
GLUTAMATE	activates	concept	0.50
Neurodegeneration	interacts_with	disease	0.50
NF-κB	activates	concept	0.50
IL-1	activates	concept	0.50
CALCIUM SIGNALING	associated_with	pathway	0.45
TYPE I INTERFERON SIGNALING	associated_with	pathway	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (7)

Scientific analyses that reference this entity

What determines the temporal transition from protective to pathological stress g

neurodegeneration | 2026-04-12 | 0 hypotheses

What determines the spatial organization of autophagy receptors at stress granul

neurodegeneration | 2026-04-08 | 0 hypotheses

What determines the specificity of RNA-protein interactions that drive distinct

neurodegeneration | 2026-04-07 | 0 hypotheses

How does TRIM21-mediated K63 ubiquitination of G3BP1 mechanistically inhibit liq

neurodegeneration | 2026-04-07 | 0 hypotheses

How do pathological stress granules transition from reversible to persistent in

neurodegeneration | 2026-04-06 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

STRESS GRANULES

Understanding Entity Pages

Wiki Pages (20)

nimodipine-als

NPM1 Gene

Frontotemporal Dementia (FTD) Mechanistic Pathway

Frontotemporal Dementia (FTD)

HNRNPA2B1 Protein

Pathway Diagram

Outgoing (82)

Incoming (99)

Targeting Hypotheses (0)

Mentioning Analyses (7)

What determines the temporal transition from protective to pathological stress g

What determines the spatial organization of autophagy receptors at stress granul

What determines the specificity of RNA-protein interactions that drive distinct

How does TRIM21-mediated K63 ubiquitination of G3BP1 mechanistically inhibit liq

How do pathological stress granules transition from reversible to persistent in

How do pathological stress granules in neurodegeneration escape TRIM21/autophagy

How do disease-associated mutations in G3BP1 or its binding partners alter stres

Related Papers (0)

STRESS GRANULES

Understanding Entity Pages

Wiki Pages (20)

nimodipine-als

NPM1 Gene

Frontotemporal Dementia (FTD) Mechanistic Pathway

Frontotemporal Dementia (FTD)

HNRNPA2B1 Protein

oxidative-stress-comparison

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

ftd-tdp-pathology

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases

rankings

TRA2B Protein - Transformer-2 Beta

Pre-symptomatic Conversion Windows in ALS Genetic Risk Carriers

Splice-Modulating Therapies for Neurodegeneration

TDP-43 Proteinopathy

Gemin-8 Protein

KARS1

RPL30 — Ribosomal Protein L30 in Neurodegeneration

Protein Aggregation Comparison in Neurodegeneration

RNA Metabolism Dysregulation in Alzheimer's Disease

Liquid Biopsy Diagnostics for Corticobasal Syndrome

Pathway Diagram

Outgoing (82)

Incoming (99)

Targeting Hypotheses (0)

Mentioning Analyses (7)

What determines the temporal transition from protective to pathological stress g

What determines the spatial organization of autophagy receptors at stress granul

What determines the specificity of RNA-protein interactions that drive distinct

How does TRIM21-mediated K63 ubiquitination of G3BP1 mechanistically inhibit liq

How do pathological stress granules transition from reversible to persistent in

How do pathological stress granules in neurodegeneration escape TRIM21/autophagy

How do disease-associated mutations in G3BP1 or its binding partners alter stres

Related Papers (0)