UBQLN2

Understanding Entity Pages

This page aggregates everything SciDEX knows about UBQLN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

UBQLN2 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with ALS, Aging, Als. Connected to 63 entities in the SciDEX knowledge graph.

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graph TD
    UBQLN2["<b>UBQLN2</b>"]
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    UBQLN2 -->|"associated with"| OXIDATIVE_STRESS
    PROTEIN_DEGRADATION(["PROTEIN_DEGRADATION"])
    UBQLN2 -->|"activates"| PROTEIN_DEGRADATION
    ALS{"ALS"}
    UBQLN2 -->|"associated with"| ALS
    HSP70["HSP70"]
    UBQLN2 -->|"interacts with"| HSP70
    UNC5B["UNC5B"]
    UBQLN2 -->|"interacts with"| UNC5B
    Neurodegeneration{"Neurodegeneration"}
    UBQLN2 -->|"therapeutic target"| Neurodegeneration
    Aging{"Aging"}
    UBQLN2 -->|"therapeutic target"| Aging
    Ms{"Ms"}
    UBQLN2 -->|"associated with"| Ms
    Als{"Als"}
    UBQLN2 -->|"therapeutic target"| Als
    UBQLN2 -->|"associated with"| Als
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    UBQLN2 -->|"associated with"| Amyotrophic_Lateral_Sclerosis
    UBQLN2 -->|"activates"| Neurodegeneration
    FUS["FUS"]
    FUS -->|"associated with"| UBQLN2
    MOTOR_NEURONS["MOTOR NEURONS"]
    MOTOR_NEURONS -->|"activates"| UBQLN2
    OXIDATIVE_STRESS -->|"associated with"| UBQLN2
    AND["AND"]
    AND -->|"activates"| UBQLN2
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"activates"| UBQLN2
    ALS -->|"activates"| UBQLN2
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"associated with"| UBQLN2
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"activates"| UBQLN2
    AGING["AGING"]
    AGING -->|"activates"| UBQLN2
    style UBQLN2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0