Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Programmed Cell Death: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Cell Type | Programmed Cell Death |
| Key Markers | ARK |
| Associated Diseases | Neurodegenerative Diseases, ALZHEIMER'S DISEASE, PARKINSON'S DISEASE, Alzheimer'S Disease, Parkinson'S Disease, ALS |
Knowledge base pages for this entity
graph TD
Programmed_Cell_Death["Programmed Cell Death"] -->|"contributes to"| Neurodegenerative_Diseases["Neurodegenerative Diseases"]
style Neurodegenerative_Diseases fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Programmed_Cell_Death["Programmed Cell Death"] -->|"involved in"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
style ALZHEIMER_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Programmed_Cell_Death["Programmed Cell Death"] -->|"involved in"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
style PARKINSON_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Programmed_Cell_Death["Programmed Cell Death"] -->|"involved in"| Neuronal_Development["Neuronal Development"]
style Neuronal_Development fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
Programmed_Cell_Death["Programmed Cell Death"] -->|"involved in"| ALS["ALS"]
style ALS fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Programmed_Cell_Death["Programmed Cell Death"] -->|"regulates"| Neuron["Neuron"]
style Neuron fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Programmed_Cell_Death["Programmed Cell Death"] -->|"causes"| Neuronal_Loss["Neuronal Loss"]
style Neuronal_Loss fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
Lncrna["Lncrna"] -->|"regulates"| Programmed_Cell_Death["Programmed Cell Death"]
style Lncrna fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
ARK["ARK"] -->|"participates in"| Programmed_Cell_Death["Programmed Cell Death"]
style ARK fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
autophagy["autophagy"] -->|"interacts"| Programmed_Cell_Death["Programmed Cell Death"]
style autophagy fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
style Programmed_Cell_Death fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| Neurodegenerative Diseases | contributes_to | disease | 0.95 |
| ALZHEIMER'S DISEASE | involved_in | disease | 0.95 |
| PARKINSON'S DISEASE | involved_in | disease | 0.95 |
| Neuronal Development | involved_in | process | 0.90 |
| Alzheimer'S Disease | involved_in | disease | 0.90 |
| Parkinson'S Disease | involved_in | disease | 0.90 |
| ALS | involved_in | disease | 0.90 |
| Neuron | regulates | cell_type | 0.90 |
| Neuronal Loss | causes | phenotype | 0.90 |
| Neural Architecture | involved_in | phenotype | 0.90 |
| Amyotrophic Lateral Sclerosis | involved_in | disease | 0.85 |
| Myocardial Ischemia/Reperfusion Injury | contributes_to | disease | 0.85 |
| Chronic Kidney Disease | contributes_to | disease | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Lncrna | regulates | process | 0.95 |
| Natural Products | modulates | compound | 0.95 |
| Apoptosis | involved_in | process | 0.90 |
| Necroptosis | involved_in | process | 0.90 |
| PI3K/AKT | regulates | pathway | 0.90 |
| ZFPs | associated_with | protein | 0.80 |
| Zinc Finger Proteins | regulates | protein | 0.80 |
| Zhenwu Decoction | inhibits | drug | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||