ARK

The debate revealed a critical gap: while PINK1/PARKIN deficiency correlates wit

closed · Rounds: 4 · Score: 0.50 · 2026-04-20

The debate revealed a critical gap: while excitatory neurons show mitochondrial

closed · Rounds: 4 · Score: 0.50 · 2026-04-20

NMN Supplementation Restores SIRT1/p66Shc/FOXO3 Epigenetic Axis and Dopaminergic

Score: 0.790 · neurodegeneration · 2026-04-22

## Mechanistic Overview NMN Supplementation Restores SIRT1/p66Shc/FOXO3 Epigenetic Axis and Dopaminergic Neuron Survival

Integrated Biomarker Panel for Therapeutic Window Identification

Score: 0.784 · neurodegeneration · 2026-04-15

## Mechanistic Overview Integrated Biomarker Panel for Therapeutic Window Identification starts from the claim that modu

GBA1/GCase restoration to reduce alpha-synuclein pathology in Parkinson's diseas

Score: 0.760 · neurodegeneration · 2026-04-29

Heterozygous GBA1 loss of function reduces beta-glucocerebrosidase activity, disrupts lysosomal lipid handling, and prom

STMN2 Cryptic Exon Inclusion is the Earliest Loss-of-Function Marker of TDP-43 N

Score: 0.760 · als · 2026-04-27

Loss of nuclear TDP-43 in ALS motor neurons first manifests as aberrant inclusion of the STMN2 cryptic exon 2a, producin

sTREM2 as Biomarker of Cystatin-C Therapeutic Efficacy

Score: 0.757 · neurodegeneration · 2026-04-17

## Mechanistic Overview sTREM2 as Biomarker of Cystatin-C Therapeutic Efficacy starts from the claim that modulating not

LAMP2A-Mediated Autophagy Enhancement Blocks Alpha-Synuclein Propagation in Park

Score: 0.745 · neurodegeneration · 2026-05-10

AAV9-mediated overexpression of LAMP2A enhances chaperone-mediated autophagy to selectively degrade pathological alpha-s

SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK1/Parkin Mitophagy D

Score: 0.738 · alzheimers · 2026-04-02

## Mechanistic Overview SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK1/Parkin Mitophagy Dysfunction start

Stage-Specific TREM2 Biomarker-Guided Switching — Agonist in Amyloid Phase, Anta

Score: 0.735 · alzheimers · 2026-04-04

## Mechanistic Overview Stage-Specific TREM2 Biomarker-Guided Switching — Agonist in Amyloid Phase, Antagonist in Tau Ph

TDP-43 condensation thermodynamics as a therapeutic target and biomarker for nuc

Score: 0.724 · neuroscience · 2026-04-26

FRAP-based measurement of TDP-43 liquid-liquid phase separation state provides a continuous biomarker of nuclear-cytopla

CSF YKL-40 as a Priming-Specific Chitinase Marker

Score: 0.723 · biomarkers · 2026-04-22

## Mechanistic Overview CSF YKL-40 as a Priming-Specific Chitinase Marker starts from the claim that modulating CHI3L1/Y

NLRP3 Inflammasome Inhibition for Neuroprotection in Parkinson's Disease

Score: 0.720 · neurodegeneration · 2026-04-28

Targeted inhibition of NLRP3 inflammasome activation attenuates alpha-synuclein-driven microglial neuroinflammation, red

Pharmacologic activation of GBA1 to reduce alpha-synuclein burden in Parkinson's

Score: 0.720 · neurodegeneration · 2026-05-01

GBA1 mutations represent the strongest genetic risk factor for PD (OR 5-20x), and GCase dysfunction creates a druggable

LRRK2 kinase inhibition to normalize lysosomal trafficking in Parkinson's diseas

Score: 0.710 · neurodegeneration · 2026-05-01

LRRK2 G2019S mutations cause autosomal dominant PD through hyperactivation that impairs vesicular trafficking via Rab GT