Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ARK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| DRONC | activates | protein | 0.80 |
| benchmark_ot_ad_answer_key:ARK | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ARK | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
drug delivery | 2026-04-15 | 0 hypotheses
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.586
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.544
neurodegeneration | 2026-04-14 | 0 hypotheses
neuroinflammation | 2026-04-14 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| SIRT1 activation by SRT2104 enhances mitophagy and reduces senescence in auditor [PMID:41593189] | ["Cho S", "Jo E", "Jang H"] | Scientific reports | 2026 | 0 |
| Targeted nanovesicular delivery of dexmedetomidine modulates microglial lysosoma [PMID:41778730] | Zhang Y, Jiang H, Zhang F, Liao J | Neural regeneration research | 2026 | 0 |
| The myocardial ischemic cascade network and multi-target synergistic interventio [PMID:41544859] | Qi L, Yi J, Shen Y, Jiang H, Yao X et al | Biochem Pharmacol | 2026 | 0 |
| Homoplantaginin ameliorates osteoarthritis by activating Sirt3/PINK1/Parkin sign [PMID:41720004] | Zhang H, Xiao J, Yi Y, Chen B, Lv W et a | Phytomedicine | 2026 | 0 |
| Kakkalide promotes spinal cord injury repair by regulating microglial M2 polariz [PMID:41720005] | You T, Dai B, Ding X, He Z, Peng J et al | Phytomedicine | 2026 | 0 |
| AARS2 R199C mutation induces lactylation-driven premature ovarian insufficiency [PMID:41832996] | Zhang HH, Zhang ZL, Xu W | Reproduction | 2026 | 0 |
| Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Indu [PMID:41905969] | Wang Y, Yuan Q | Clin Exp Pharmacol Physiol | 2026 | 0 |
| FGFR1 suppresses ovarian cancer progression by modulating SIRT3-dependent lactyl [PMID:41946672] | Jiang F, Huang H, Dong Z, Zhang L, Zhang | Cell Death Discov | 2026 | 0 |
| Adipocyte small extracellular vesicle-derived microRNA-30a-3p exacerbates hepati [PMID:41965824] | Zhang T, Hu L, Chen D, Chen Y, Zhou F et | Nat Commun | 2026 | 0 |
| α7-nAChR activation mitigates pyridaben-induced hepatotoxicity in grass carp (Ct [PMID:41966317] | Wu C, Jiang J, Qiu H, Xie J, Li S | Fish Shellfish Immunol | 2026 | 0 |
| Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated [PMID:41896899] | Fang Y, Deng M, Huang K, Song H, Chu Y, | Cell communication and signali | 2026 | 0 |
| Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via P [PMID:41906653] | Xu Z, Cui X, Chu H, Wan H, Xie Y, Wang Y | Journal of diabetes | 2026 | 0 |
| Inhibition of mitochondrial ROS turns LC3-associated phagocytosis to autophagy u [PMID:41896101] | Cheng YL, Su MS, Liao CC, Chang TW, Hsie | Journal of microbiology, immun | 2026 | 0 |
| Hyperoside stabilizes ACAT1 to promote fatty acid oxidation and attenuate kidney [PMID:41903436] | Shan C, Szili-Torok T, Yue G, Zhang L, M | Phytomedicine : international | 2026 | 0 |
| Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promotin [PMID:41897550] | ["Gao L", "Shen J", "Gao J", "Li T", "Ya | Antioxidants (Basel, Switzerla | 2026 | 0 |
| Comprehensive Insights Into Mitophagy: Mechanisms, Disease Associations, and The [PMID:40714832] | ["Tang M", "Outissint I", "Chen Y", "Gon | Journal of cellular biochemist | 2025 | 0 |
| Sirtuins as mediators and targets of arsenic toxicity: unraveling signaling path [PMID:40844627] | El-Mahrouk SR, El-Kadi AOS | Archives of toxicology | 2025 | 0 |
| Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinf [PMID:40089796] | Liu C, Zhao Y, Zhang W, Dao JJ, Li Q, Hu | Journal of neuroinflammation | 2025 | 0 |
| Phenylpropanoids of Eleutherococcus senticosus (Rupr. & maxim.) maxim. Alleviate [PMID:40081261] | Yang R, Meng X, Zhao W, Xu SQ, Wang SY, | Bioorganic chemistry | 2025 | 0 |
| Small molecule DDQ involvement of ERK-mediated signaling pathway with enhanced m [PMID:40222458] | Pradeepkiran JA, Kshirsagar S, Alvir RV, | Biochimica et biophysica acta. | 2025 | 0 |