disease

Chronic Kidney Disease

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Chronic Kidney Disease: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

363Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	PI3K, AKT, MITOCHONDRIAL DYSFUNCTION, GENES, DIABETES MELLITUS, NEURODEGENERATIVE DISORDERS, CANCER, INFLAMMATION
Therapeutic Agents	CAR-T Therapy, Car-T Therapy, Zhenwu Decoction, Telmisartan, Aconite, telmisartan
KG Connections	327 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Chronic_Kidney_Disease["<b>Chronic Kidney Disease</b>"]
    Indoxyl_Sulfate["Indoxyl Sulfate"]
    Chronic_Kidney_Disease -->|"upregulates"| Indoxyl_Sulfate
    Fibrosis{"Fibrosis"}
    Chronic_Kidney_Disease -->|"therapeutic_target"| Fibrosis
    Alzheimer_s_Disease{"Alzheimer's Disease"}
    Chronic_Kidney_Disease -->|"risk_factor_for"| Alzheimer_s_Disease
    P2Y12["P2Y12"]
    Chronic_Kidney_Disease -->|"associated_with"| P2Y12
    Apoptosis["Apoptosis"]
    Chronic_Kidney_Disease -->|"activates"| Apoptosis
    Tgf__["Tgf-Beta"]
    Chronic_Kidney_Disease -->|"therapeutic_target"| Tgf__
    CAR_T_Therapy["["CAR-T Therapy""]]
    CAR_T_Therapy -->|"treats"| Chronic_Kidney_Disease
    INFLAMMATION(["INFLAMMATION"])
    INFLAMMATION -->|"treats"| Chronic_Kidney_Disease
    APOPTOSIS(["APOPTOSIS"])
    APOPTOSIS -->|"activates"| Chronic_Kidney_Disease
    style Chronic_Kidney_Disease fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0

Outgoing (137)

Target	Relation	Type	Str
Cognitive Impairment	causes	disease	0.95
End-Stage Renal Disease	causes	disease	0.90
Indoxyl Sulfate	upregulates	compound	0.85
Fibrosis	therapeutic_target	disease	0.85
Alzheimer's Disease	risk_factor_for	disease	0.80
Apoptosis	activates	pathway	0.80
Tgf-Β	therapeutic_target	pathway	0.80
Oxidative Stress	therapeutic_target	pathway	0.80
Inflammation	treats	disease	0.75
Inflammation	regulates	disease	0.75
Alzheimer's Disease	associated_with	disease	0.75
Plasma Phosphorylated Tau-217	associated_with	biomarker	0.75
Autophagy	activates	pathway	0.70
Mitophagy	activates	pathway	0.70
Oxidative Stress	regulates	pathway	0.70
Epigenetic	regulates	pathway	0.70
Apoptosis	therapeutic_target	pathway	0.70
P2Ry12	upregulates	protein	0.70
Type 2 Diabetes	inhibits	disease	0.65
Fibrosis	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Fibrosis	causes	disease	0.65
Type 2 Diabetes	treats	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Cardiovascular	causes	disease	0.65
Inflammation	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Oxidative Stress	treats	pathway	0.60
Autophagy	treats	pathway	0.60
Apoptosis	treats	pathway	0.60
Pi3K/Akt	implicated_in	pathway	0.60
Oxidative Stress	activates	pathway	0.60
Pi3K/Akt	inhibits	pathway	0.60
Mapk	inhibits	pathway	0.60
Nf-Κb	inhibits	pathway	0.60
Inflammasome	inhibits	pathway	0.60
Epithelial-Mesenchymal Transition	activates	pathway	0.60
Tgf-Β	activates	pathway	0.60
Glycolysis	causes	pathway	0.60
Mtor	activates	pathway	0.60
Ferroptosis	activates	pathway	0.60
Apoptosis	regulates	pathway	0.60
Oxidative Phosphorylation	regulates	pathway	0.60
Dna Methylation	regulates	pathway	0.60
Histone Modification	regulates	pathway	0.60
Nf-Κb	protects_against	pathway	0.60
Mitochondrial Function	therapeutic_target	pathway	0.60
Lipid Metabolism	therapeutic_target	pathway	0.60
Senescence	therapeutic_target	pathway	0.60

Incoming (226)

Source	Relation	Type	Str
Ferroptosis	associated_with	process	0.95
Ferroptosis	involved_in	process	0.95
CAR-T Therapy	treats	drug	0.90
Ferroptosis	contributes_to	process	0.90
Ferroptosis	causes	process	0.90
Gliflozins	protects_against	drug	0.90
Type 2 Diabetes	risk_factor_for	disease	0.90
Car-T Therapy	treats	drug	0.90
Dysregulation of YAP/Autophagy Pathway	associated_with	pathway	0.90
Zhenwu Decoction	treats	drug	0.90
Kidney Function Decline	biomarker_for	phenotype	0.90
Kidney Structural Damage	biomarker_for	phenotype	0.90
KL	implicated_in	protein	0.90
INFLAMMATION	treats	gene	0.85
APOPTOSIS	activates	gene	0.85
INFLAMMATION	regulates	gene	0.85
OXIDATIVE STRESS	therapeutic_target	gene	0.85
Extracellular Matrix Production	contributes_to	process	0.85
Extracellular Matrix	involved_in	process	0.85
Fibrosis	contributes_to	process	0.85
Programmed Cell Death	contributes_to	process	0.85
Apoptosis	contributes_to	process	0.85
Necroptosis	contributes_to	process	0.85
Kidney Fibrosis	associated_with	phenotype	0.85
Kidney Damage	biomarker_for	phenotype	0.85
kidney damage	biomarker_for	phenotype	0.85
Redox Imbalance	contributes_to	mechanism	0.80
Fibrosis	associated_with	disease	0.80
MTOR	therapeutic_target	protein	0.80
Apoptosis	drives	process	0.80
Necroptosis	drives	process	0.80
telmisartan	treats	drug	0.80
CHIP	associated_with	disease	0.75
AUTOPHAGY	activates	gene	0.75
AMPK	inhibits	gene	0.75
PINK1	activates	gene	0.75
MITOPHAGY	activates	gene	0.75
INFLAMMATION	activates	gene	0.75
PARKIN	activates	gene	0.75
Als	associated_with	disease	0.75
OXIDATIVE STRESS	regulates	gene	0.75
CANCER	causes	gene	0.75
APOPTOSIS	therapeutic_target	gene	0.75
NEURODEGENERATION	associated_with	gene	0.75
EGFR	associated_with	gene	0.75
PER	associated_with	gene	0.75
INFLAMMATION	associated_with	gene	0.75
NRF2	regulates	gene	0.75
PIEZO1	therapeutic_target	gene	0.75
Doxorubicin-induced Nephropathy	associated_with	disease	0.75

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Chronic Kidney Disease

Understanding Entity Pages

Wiki Pages (20)

Mediterranean and MIND Diets for Neurodegeneration

Cerebral Small Vessel Disease

Creatine for Neuroprotection

Beta-Amyloid 42/40 Ratio - Biomarker

FGF23 — Fibroblast Growth Factor 23

Liver-Brain Neurodegeneration Axis

epas1-protein

Kidney-Brain Neurodegeneration Axis

intermittent-fasting-neurodegeneration

sglt2-inhibitors-neurodegeneration

SLC9A3 — Solute Carrier Family 9 Member 3 (Na+/H+ Exchanger 3)

Hypoxia Response Pathway

Glial Fibrillary Acidic Protein (GFAP)

Nrf2 Signaling in Neurodegeneration

ANT2 (Adenine Nucleotide Translocator 2)

LRP2 — Low Density Lipoprotein Receptor-Related Protein 2 (Megalin)

Alpha-Klotho in Neurodegeneration

NRF2 Signaling Pathway in Neurodegeneration