RAB

The debate highlighted that G2019S shows elevated baseline RAB10 phosphorylation

closed · Rounds: 4 · Score: 0.80 · 2026-04-26

Do pathogenic LRRK2 mutations amplify volume-sensing signals or just elevate bas

closed · Rounds: 4 · Score: 0.74 · 2026-04-24

G2019S Acts as Lysosomal Volume-Sensing Amplifier via Enhanced RAB29-Dependent R

Score: 0.730 · neurodegeneration · 2026-04-26

G2019S specifically hyperactivates LRRK2 when recruited to swelling lysosomes via RAB29, creating pathogenic positive fe

Regional TREM2-Dependent Lipid Metabolism Determines Cortical Vulnerability in A

Score: 0.721 · neuroinflammation · 2026-04-22

## Mechanistic Overview Regional TREM2-Dependent Lipid Metabolism Determines Cortical Vulnerability in Alzheimer's Disea

RAB29 Is the Critical Molecular Switch That Determines Whether LRRK2 Signal Ampl

Score: 0.710 · neurodegeneration · 2026-04-26

RAB29 functions as a gatekeeper—when lysosomes swell, RAB29-GTP increases, recruits LRRK2, and G2019S hyperphosphorylate

Rab27A/B-mediated exosomal tau secretion from microglia drives frontal cortex pr

Score: 0.690 · neurodegeneration · 2026-04-21

## Mechanistic Overview Rab27A/B-mediated exosomal tau secretion from microglia drives frontal cortex propagation at Bra

Astrocyte Reactivity Heterogeneity with APOE4-Dependent Vulnerability

Score: 0.690 · neurodegeneration · 2026-04-22

## Mechanistic Overview Astrocyte Reactivity Heterogeneity with APOE4-Dependent Vulnerability starts from the claim that

Microglial NOX2 establishes an inflammatory ROS propagation loop around vulnerab

Score: 0.680 · neurodegeneration · 2026-04-25

Dying or stressed neurons release alpha-synuclein and DAMPs that activate microglia, which then generate superoxide thro

A downstream LRRK2-Rab10-JIP4 lysosomal stress loop promotes alpha-synuclein rel

Score: 0.680 · neurodegeneration · 2026-04-24

Even if G2019S mainly elevates the kinase floor, that increase may still become pathogenic by pushing a thresholded down

Selective Tau Kinase Inhibition in Vulnerable Neuronal Subtypes

Score: 0.676 · neurodegeneration · 2026-04-13

## Mechanistic Overview Selective Tau Kinase Inhibition in Vulnerable Neuronal Subtypes starts from the claim that modul

Excitatory Neuron Vulnerability via SLC17A7 Downregulation

Score: 0.675 · alzheimers · 2026-04-02

## Mechanistic Overview Excitatory Neuron Vulnerability via SLC17A7 Downregulation starts from the claim that modulating

RAB27A-dependent extracellular vesicle engineering for mitochondrial cargo deliv

Score: 0.674 · neurodegeneration · 2026-04-02

## Mechanistic Overview RAB27A-dependent extracellular vesicle engineering for mitochondrial cargo delivery starts from

OPTN/TBK1 mutations create selective vulnerability by blocking PINK1-Parkin-inde

Score: 0.670 · neurodegeneration · 2026-04-21

## Mechanistic Overview OPTN/TBK1 mutations create selective vulnerability by blocking PINK1-Parkin-independent mitophag

Rab12 may better report chronic lysosomal stress biology than Rab10 in G2019S co

Score: 0.670 · neurodegeneration · 2026-04-24

The strongest biomarker-oriented hypothesis is not that Rab12 is the main pathogenic target, but that pRab12 may outperf

White Matter Vulnerability Prevention via Oligodendrocyte Protection

Score: 0.667 · neurodegeneration · 2026-04-04

## Mechanistic Overview White Matter Vulnerability Prevention via Oligodendrocyte Protection starts from the claim that

Parvalbumin Interneuron Vulnerability Links Lactate Transport to Gamma Oscillati

Score: 0.656 · neurodegeneration · 2026-04-14

## Mechanistic Overview Parvalbumin Interneuron Vulnerability Links Lactate Transport to Gamma Oscillation Dysfunction s