entity

RAB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections
15Hypotheses
30Analyses
1Outgoing
1Incoming

Wiki Pages (20)

Knowledge base pages for this entity

Vesicle Trafficking Dysfunction in Corticobasal Syndrome

mechanism · 4859 words

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases

mechanism · 4604 words

Synaptic Vesicle Trafficking in Parkinson's Disease

mechanism · 4417 words

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

mechanism · 4337 words

LRRK2 Pathway in Parkinson's Disease

mechanism · 4238 words

Outgoing (1)

TargetRelationTypeStr
LRRK2activatesprotein0.90

Incoming (1)

SourceRelationTypeStr
LRRK2interacts_withprotein0.95

Targeting Hypotheses (15)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
CLU/APOE Duality in Amyloid Clearance Determines Cell-Type-S 0.576 neurodegeneration What are the cell-type-specific transcri
Parvalbumin Interneuron Vulnerability Links Lactate Transpor 0.569 neurodegeneration What is the molecular mechanism by which
Layer V excitatory neurons show selectively enhanced vulnera 0.510 Alzheimer's disease SEA-AD Single-Cell Analysis: Cell-Type V
Selective Tau Kinase Inhibition in Vulnerable Neuronal Subty 0.504 neurodegeneration Cell type vulnerability in Alzheimers Di
Dual-Circuit Tau Vulnerability Cascade 0.499 neuroscience Circuit-level neural dynamics in neurode
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vul 0.485 Alzheimer's Disease Cell type vulnerability in Alzheimers Di
Age-Dependent Complement C4b Upregulation Drives Synaptic Vu 0.470 neurodegeneration Gene expression changes in aging mouse b
White Matter Vulnerability Prevention via Oligodendrocyte Pr 0.468 neurodegeneration Gene expression changes in aging mouse b
Dual-Circuit Tau Vulnerability Cascade with Glial-Mediated A 0.461 neuroscience Circuit-level neural dynamics in neurode
Complement Cascade Activation Bridges Microglial OxPC Sensin 0.452 neuroinflammation What molecular mechanisms enable microgl
Excitatory Neuron Vulnerability via SLC17A7 Downregulation 0.445 Alzheimer's Disease SEA-AD Gene Expression Profiling — Allen
Spatially-Targeted Regional Vulnerability Prevention 0.444 neurodegeneration Cell type vulnerability in Alzheimers Di
Selective Neuronal Vulnerability Network Targeting 0.431 neurodegeneration Gene expression changes in aging mouse b
RAB27A-dependent extracellular vesicle engineering for mitoc 0.414 neurodegeneration Mitochondrial transfer between astrocyte
Oligodendrocyte White Matter Vulnerability 0.398 neurodegeneration Gene expression changes in aging mouse b

Mentioning Analyses (30)

Scientific analyses that reference this entity

What are the cell-type-specific transcriptomic signatures of vulnerability in SE

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.576

What determines the GPX4/ACSL4 balance that switches microglia from protective t

immunology | 2026-04-15 | 0 hypotheses

How do ALS-associated OPTN mutations mechanistically disrupt Rab8a binding and c

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.521

Which specific cell types show greatest vulnerability in AD based on SEA-AD tran

neurodegeneration | 2026-04-11 | 0 hypotheses

Which cell-type vulnerability signatures from SEA-AD single-cell data represent

systems biology | 2026-04-11 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] Zhou Y, Song WM, Andhey PS, Swain A, Lev Nat Med 2020 1
Repurposing of doxycycline as a novel therapeutic avenue for management of parki [PMID:41925933] Ali NH, Al-Kuraishy HM, Hussain NR, Al-G Inflammopharmacology 2026 0
Histological findings in follow-up liver biopsies up to 15 years after pediatric [PMID:41370831] Quintero-Bernabeu J, Salcedo-Allende MT, Liver Transpl 2026 0
Protein Corona Reprograms Hepatic Clearance Pathways of Biomimetic Nanoparticles [PMID:41944292] He T, Fang X, Zhu L, Fan H, Qiu Y et al. Small 2026 0
Mid-Term Comparison of N-Butyl Cyanoacrylate, Endovenous Laser Ablation, and Rad [PMID:41964281] Dilek I, Kocaoglu AS, Büyükceran EU, Nay Vasc Endovascular Surg 2026 0
Knee Osteoarthritis as a Causal Risk Factor for Parkinson's Disease: Converging [PMID:41925436] Peng Z, Wang G The American journal of geriat 2026 0
Reactive astrocyte subpopulations with high Gfap and C4b expression in different [PMID:41837502] Huang C, Han Y, He J, Ma W, Chen Y, Dong Neural regeneration research 2026 0
Longitudinal investigation of the T helper (Th)1-Th2 balance and complement syst [PMID:41872173] Zhang T, Zhao J, Tang X, Wei Y, Ju M, Zh Translational psychiatry 2026 0
Unveiling the choroidal immune landscape revealed interferon-gamma and TNF-alpha [PMID:41077603] Ye L, Zhao T, Tian H, Li R, Li Z et al. Sci China Life Sci 2026 0
The mechanism of Qing-Fei-Yin decoction against influenza: Synergistical inhibit [PMID:41317805] Nie W, Wang M, Cheng M, Ren Z, Liu G et J Ethnopharmacol 2026 0
Elucidating the biological characteristics of overweight populations based on ur [PMID:41529508] Li Y, Miao Y, Liang H, Zhou K, Li R et a Spectrochim Acta A Mol Biomol 2026 0
Indole-3-propionic acid inhibits astrocyte inflammation and promotes motor funct [PMID:41663028] Yu D, Kang J, Jiang W, Zhang C, Zhao X e Neuropharmacology 2026 0
Cobrotoxin mitigates neuroinflammation and cognitive impairment by suppressing C [PMID:41671614] Li Z, Tan B, Dong K, Yu X, Zhang SW et a Biochem Pharmacol 2026 0
Peripheral macrophages and T-cells accumulate in the degenerating optic tract af [PMID:41740873] Main BS, Villapol S, Buenaventura RG, Ha Brain Behav Immun 2026 0
Melanoma cell inoculation improves cognitive impairment in the 5xFAD mouse model [PMID:41760781] Bruna-Jara B, More J, Lobos P, Ponce DP, Scientific reports 2026 0
Microenvironment-educated MSC-EVs loaded injectable smart hydrogel for targeting [PMID:41799958] Wu W, Cheng Z, Shi P, Gao H, Chen X et a Bioact Mater 2026 0
Genetic Variation in the Chemokine Network and Atherosclerosis Risk. [PMID:41824188] Zangas P, Georgakis MK Curr Atheroscler Rep 2026 0
Primary Infection with Cystoisospora suis Modulates Systemic Immunity and the Gu [PMID:41942044] Ye X, Huang YJ, Deng XL, He ZY, Tan JJ e Int J Parasitol 2026 0
Early repetitive transcranial magnetic stimulation for preventing chronic postop [PMID:41943114] Zhou WW, Yang Z, Zhou C, Qiao Q, Zhang Y BMC Med 2026 0
HTLV1-associated myelopathy as a translational model of progressive neurodegener [PMID:41926707] da Silva MTT, Araujo AQC Brain : a journal of neurology 2026 0