gene 1,823 words KG: RAB7L1
Contents

RAB7L1 (RAB7 Like 1)

🧬 Gene Info
Gene SymbolRAB7L1
Full NameRAB7 Like 1
Chromosome9q31.3
Functionis a member of the Rab GTPase family that plays critical roles in late endosomal and lysosomal trafficking pathways.
Primary ExpressionBrain, heart, kidney, liver
Subcellular Localizationthrough geranylgeranyl lipid modification
Molecular Weight21 kDa
Amino Acids183 aa
Exons7
PathwaysVesicle Trafficking
UniProt IDQ9BY66
NCBI Gene ID57171
Ensembl IDENSG00000142530
OMIM614930
GeneCardsRAB7L1
Human Protein AtlasRAB7L1
Associated DiseasesALS, dementia, frontotemporal
InteractionsARHGEF7, AUTOPHAGY, C9ORF72, CDC42, GAIN, LRRK2
KG Connections58 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (5)

Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.78
Autophagosome Maturation Checkpoint Control
Score: 0.71
VCP-Mediated Autophagy Enhancement
Score: 0.59
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (3)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Amyotrophic Lateral Sclerosis
redirect · KG edge: regulates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: interacts_with
c9orf72-als-ftd-phenotype-mechanism
general · KG edge: interacts_with
ARHGEF7 Gene
gene · KG edge: interacts_with
C9orf72 — Chromosome 9 Open Reading Frame 72
gene · KG edge: activates

Knowledge Graph (12 edges)

GAIN activates RAB7L1
C9ORF72 regulates RAB7L1
RAB7L1 activates GAIN
RAB7L1 interacts_with ARHGEF7
RAB7L1 interacts_with RAC1
RAB7L1 interacts_with LRRK2
RAB7L1 interacts_with RGS2
RAB7L1 interacts_with CDC42
RAB7L1 interacts_with RAB5
GAIN transports RAB7L1

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