gene

RANBP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RANBP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

32Connections
0Hypotheses
0Analyses
28Outgoing
4Incoming

Summary

RANBP2 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, implicated in. Associated with ALS, Als, Cancer. Connected to 18 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolRANBP2
Full NameRAN Binding Protein 2
Chromosome2q12.3
FunctionRANBP2 encodes a massive 3224 amino acid protein that serves as a critical component of the nuclear pore complex (NPC).
Primary Expressionbrainstem nuclei
Molecular Weight358 kDa
Amino Acids3224 aa
PathwaysAutophagy, Glycolysis, RANGAP1-SUMO1 Complex Formation
UniProt IDP49792
NCBI Gene ID9918
Ensembl IDENSG00000136404
OMIM601181
GeneCardsRANBP2
Human Protein AtlasRANBP2
Associated DiseasesAcute Necrotizing Encephalopathy
InteractionsSUMO1, SUMO2, NBR1, FOXO1, UBIQUITIN, CKAP4
KG Connections32 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: RANBP2 — AlphaFold P49792 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (18)

Knowledge base pages for this entity

Canonical Page

RANBP2 — RAN Binding Protein 2

gene · 534 words

cbs-psp-daily-action-plan

therapeutic · 30834 words

Protein SUMOylation Pathway in Neurodegeneration

mechanism · 3042 words

Nucleocytoplasmic Transport Defects in Neurodegenerative Diseases

mechanism · 2930 words

RAN Gene

gene · 2633 words

sumoylation

mechanism · 2034 words

Pathway Diagram

graph TD
    RANBP2["<b>RANBP2</b>"]
    Ms{"Ms"}
    RANBP2 -->|"interacts with"| Ms
    Als{"Als"}
    RANBP2 -->|"interacts with"| Als
    Carcinoma{"Carcinoma"}
    RANBP2 -->|"activates"| Carcinoma
    Cancer{"Cancer"}
    RANBP2 -->|"activates"| Cancer
    Tumor{"Tumor"}
    RANBP2 -->|"activates"| Tumor
    ALS{"ALS"}
    RANBP2 -->|"interacts with"| ALS
    SUMO1["SUMO1"]
    RANBP2 -->|"interacts with"| SUMO1
    SUMO2["SUMO2"]
    RANBP2 -->|"interacts with"| SUMO2
    AUTOPHAGY["AUTOPHAGY"]
    RANBP2 -->|"activates"| AUTOPHAGY
    NBR1["NBR1"]
    RANBP2 -->|"activates"| NBR1
    Autophagy(["Autophagy"])
    RANBP2 -->|"activates"| Autophagy
    Glycolysis(["Glycolysis"])
    RANBP2 -->|"activates"| Glycolysis
    SUMO1 -->|"interacts with"| RANBP2
    SUMO2 -->|"interacts with"| RANBP2
    CKAP4["CKAP4"]
    CKAP4 -->|"activates"| RANBP2
    AND["AND"]
    AND -->|"interacts with"| RANBP2
    style RANBP2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (28)

TargetRelationTypeStr
RANGAP1interacts_withprotein0.95
UBC9interacts_withprotein0.95
SUMO1exhibits_specificity_forprotein0.90
SUMO1exhibits_E3_ligase_activity_forprotein0.90
RANGAP1-SUMO1 Complex Formationregulatesprocess0.85

Incoming (4)

SourceRelationTypeStr
SUMO1interacts_withgene0.60
SUMO2interacts_withgene0.60
CKAP4activatesgene0.60
HIF-1Αactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found