Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RANBP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RANBP2 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, implicated in. Associated with ALS, Als, Cancer. Connected to 18 entities in the SciDEX knowledge graph.
| Gene Symbol | RANBP2 |
| Full Name | RAN Binding Protein 2 |
| Chromosome | 2q12.3 |
| Function | RANBP2 encodes a massive 3224 amino acid protein that serves as a critical component of the nuclear pore complex (NPC). |
| Primary Expression | brainstem nuclei |
| Molecular Weight | 358 kDa |
| Amino Acids | 3224 aa |
| Pathways | Autophagy, Glycolysis, RANGAP1-SUMO1 Complex Formation |
| UniProt ID | P49792 |
| NCBI Gene ID | 9918 |
| Ensembl ID | ENSG00000136404 |
| OMIM | 601181 |
| GeneCards | RANBP2 |
| Human Protein Atlas | RANBP2 |
| Associated Diseases | Acute Necrotizing Encephalopathy |
| Interactions | SUMO1, SUMO2, NBR1, FOXO1, UBIQUITIN, CKAP4 |
| KG Connections | 32 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RANBP2["<b>RANBP2</b>"]
Ms{"Ms"}
RANBP2 -->|"interacts with"| Ms
Als{"Als"}
RANBP2 -->|"interacts with"| Als
Carcinoma{"Carcinoma"}
RANBP2 -->|"activates"| Carcinoma
Cancer{"Cancer"}
RANBP2 -->|"activates"| Cancer
Tumor{"Tumor"}
RANBP2 -->|"activates"| Tumor
ALS{"ALS"}
RANBP2 -->|"interacts with"| ALS
SUMO1["SUMO1"]
RANBP2 -->|"interacts with"| SUMO1
SUMO2["SUMO2"]
RANBP2 -->|"interacts with"| SUMO2
AUTOPHAGY["AUTOPHAGY"]
RANBP2 -->|"activates"| AUTOPHAGY
NBR1["NBR1"]
RANBP2 -->|"activates"| NBR1
Autophagy(["Autophagy"])
RANBP2 -->|"activates"| Autophagy
Glycolysis(["Glycolysis"])
RANBP2 -->|"activates"| Glycolysis
SUMO1 -->|"interacts with"| RANBP2
SUMO2 -->|"interacts with"| RANBP2
CKAP4["CKAP4"]
CKAP4 -->|"activates"| RANBP2
AND["AND"]
AND -->|"interacts with"| RANBP2
style RANBP2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| RANGAP1 | interacts_with | protein | 0.95 |
| UBC9 | interacts_with | protein | 0.95 |
| SUMO1 | exhibits_specificity_for | protein | 0.90 |
| SUMO1 | exhibits_E3_ligase_activity_for | protein | 0.90 |
| RANGAP1-SUMO1 Complex Formation | regulates | process | 0.85 |
| Protease Degradation | protects_against | process | 0.85 |
| Ms | interacts_with | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Carcinoma | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| Infection | activates | disease | 0.65 |
| SUMO1 | interacts_with | gene | 0.60 |
| SUMO2 | interacts_with | gene | 0.60 |
| NBR1 | activates | gene | 0.60 |
| FOXO1 | interacts_with | gene | 0.60 |
| UBIQUITIN | interacts_with | gene | 0.60 |
| CKAP4 | activates | gene | 0.60 |
| SUMO1 | protects_against | entity | 0.60 |
| SUMO1 | activates | entity | 0.60 |
| Sumo | interacts_with | protein | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Glycolysis | activates | pathway | 0.60 |
| AND | activates | gene | 0.60 |
| HIF | activates | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||