Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HIF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
HIF is a concept in neurodegeneration research. Key relationships include: activates, interacts with, therapeutic target. Associated with AD, ALI, ALS. Connected to 636 entities in the SciDEX knowledge graph.
| Name | HIF |
| Summary | Page for HIF-1α Stabilization Therapy for Neurodegeneration |
| Key Genes/Proteins | CANCER, GENES, AKT, MTOR, INFLAMMATION, MYC |
| Related Diseases | Cancer, Tumor, Inflammation, Als, Carcinoma |
| Related Pathways | Glycolysis, Mtor, Pi3K/Akt |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
HIF["HIF"]
HIF -->|"activates"| ALS["ALS"]
HIF -->|"activates"| Carcinoma["Carcinoma"]
HIF -->|"activates"| Cancer["Cancer"]
HIF -->|"interacts"| Alzheimer["Alzheimer"]
HIF -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
HIF -->|"interacts"| Dementia["Dementia"]
HIF -->|"interacts"| Cardiovascular["Cardiovascular"]
HIF -->|"interacts"| Parkinson["Parkinson"]
HIF -->|"activates"| Tumor["Tumor"]
VHL["VHL"] -->|"regulates"| HIF
BCL2L11["BCL2L11"] -->|"interacts"| HIF
DNA["DNA"] -->|"interacts"| HIF
NIX["NIX"] -->|"interacts"| HIF
HIF1["HIF1"] -->|"interacts"| HIF
RB1["RB1"] -->|"interacts"| HIF
NLRP3["NLRP3"] -->|"interacts"| HIF
PARKINSON["PARKINSON"] -->|"interacts"| HIF
FMR1["FMR1"] -->|"interacts"| HIF
RB1CC1["RB1CC1"] -->|"interacts"| HIF| Target | Relation | Type | Str |
|---|---|---|---|
| CANCER | activates | gene | 1.00 |
| Cancer | activates | disease | 1.00 |
| Glycolysis | activates | pathway | 1.00 |
| Tumor | activates | disease | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Pi3K/Akt | activates | pathway | 1.00 |
| GENES | activates | gene | 1.00 |
| Inflammation | activates | disease | 1.00 |
| AKT | activates | gene | 1.00 |
| MTOR | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| Als | activates | disease | 1.00 |
| MYC | activates | gene | 1.00 |
| Carcinoma | activates | disease | 0.95 |
| Cancer | therapeutic_target | disease | 0.95 |
| Cancer | regulates | disease | 0.95 |
| oxidative stress response | participates_in | pathway | 0.90 |
| Oxidative Phosphorylation | activates | pathway | 0.90 |
| MITOCHONDRIA | activates | gene | 0.90 |
| CANCER | regulates | gene | 0.90 |
| Tumor | therapeutic_target | disease | 0.85 |
| Inflammation | regulates | disease | 0.85 |
| iron homeostasis | regulates | process | 0.85 |
| PI3K-AKT-mTOR signaling | participates_in | pathway | 0.80 |
| unfolded protein response | participates_in | pathway | 0.80 |
| apoptosis pathway | participates_in | pathway | 0.80 |
| microglia | expressed_in | cell_type | 0.80 |
| neural stem cells | activates | cell_type | 0.80 |
| AMPK | activates | gene | 0.80 |
| Oxidative Stress | inhibits | pathway | 0.80 |
| MTOR | associated_with | gene | 0.80 |
| Mtor | associated_with | pathway | 0.80 |
| Epigenetic | activates | pathway | 0.80 |
| RAS | activates | gene | 0.80 |
| Mapk | activates | pathway | 0.80 |
| NF-ΚB | activates | gene | 0.80 |
| Nf-Κb | activates | pathway | 0.80 |
| Lipid Metabolism | regulates | pathway | 0.80 |
| MICROGLIA | activates | gene | 0.80 |
| Glycolysis | regulates | pathway | 0.80 |
| CANCER | therapeutic_target | gene | 0.80 |
| Autophagy | inhibits | pathway | 0.80 |
| Stem Cell | inhibits | pathway | 0.80 |
| Oxidative Stress | therapeutic_target | pathway | 0.80 |
| Angiogenesis | activates | pathway | 0.80 |
| Apoptosis | activates | pathway | 0.80 |
| Ischemia | inhibits | disease | 0.75 |
| Cancer | inhibits | disease | 0.75 |
| Infection | activates | disease | 0.75 |
| Renal Cell Carcinoma | activates | disease | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PI3K | activates | gene | 1.00 |
| VHL | degrades | protein | 0.95 |
| OXIDATIVE STRESS | inhibits | gene | 0.80 |
| STAT3 | therapeutic_target | gene | 0.80 |
| PI3K | associated_with | gene | 0.80 |
| VHL | activates | gene | 0.80 |
| OXIDATIVE STRESS | therapeutic_target | gene | 0.80 |
| STAT3 | activates | gene | 0.80 |
| VHL | regulates | gene | 0.72 |
| INFLAMMATION | activates | gene | 0.70 |
| SLC7A11 | inhibits | gene | 0.70 |
| APOPTOSIS | therapeutic_target | gene | 0.70 |
| NAD | activates | gene | 0.70 |
| HK2 | activates | gene | 0.70 |
| PTEN | activates | gene | 0.70 |
| CD44 | therapeutic_target | gene | 0.70 |
| ERK | inhibits | gene | 0.70 |
| APOPTOSIS | activates | gene | 0.70 |
| APOPTOSIS | implicated_in | gene | 0.70 |
| PARKINSON'S DISEASE | therapeutic_target | gene | 0.70 |
| AKT1 | therapeutic_target | gene | 0.70 |
| ATG5 | regulates | gene | 0.70 |
| BCL2L11 | interacts_with | gene | 0.60 |
| DNA | interacts_with | gene | 0.60 |
| NIX | interacts_with | gene | 0.60 |
| HIF1 | interacts_with | gene | 0.60 |
| RB1 | interacts_with | gene | 0.60 |
| NLRP3 | interacts_with | gene | 0.60 |
| PARKINSON | interacts_with | gene | 0.60 |
| FMR1 | interacts_with | gene | 0.60 |
| RB1CC1 | interacts_with | gene | 0.60 |
| PARL | interacts_with | gene | 0.60 |
| EIF2S1 | interacts_with | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | interacts_with | gene | 0.60 |
| ALS | interacts_with | gene | 0.60 |
| CALCOCO2 | interacts_with | gene | 0.60 |
| MIRO1 | interacts_with | gene | 0.60 |
| PTEN | interacts_with | gene | 0.60 |
| MFN1 | interacts_with | gene | 0.60 |
| PERK | interacts_with | gene | 0.60 |
| ATP | interacts_with | gene | 0.60 |
| MITOCHONDRIA | interacts_with | gene | 0.60 |
| PGAM5 | interacts_with | gene | 0.60 |
| MAP1LC3B | interacts_with | gene | 0.60 |
| BECN1 | interacts_with | gene | 0.60 |
| RHOT1 | interacts_with | gene | 0.60 |
| RETREG1 | interacts_with | gene | 0.60 |
| AUTOPHAGY | interacts_with | gene | 0.60 |
| STING1 | interacts_with | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Targeting SASP-Complement Amplification Through HIF-1α Downs | 0.610 | neurodegeneration | What molecular mechanism causes VCP muta |
Scientific analyses that reference this entity
neuroimmunology | 2026-04-15 | 2 hypotheses Top: 0.674
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.609
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.610
neurodegeneration | 2026-04-12 | 0 hypotheses
neurodegeneration | 2026-04-11 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||