Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RGS5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | RGS5 |
| Full Name | Regulator of G Protein Signaling 5 |
| Chromosome | 1q23.3 |
| Function | By accelerating GTP hydrolysis on Gαq subunits, RGS5 terminates signaling from vasoconstrictor receptors including angiotensin II (AT1R), endothelin-1 (ETA), and α1-adrenergic receptors. |
| Primary Expression | Vascular smooth muscle cells, Pericytes, Brain vasculature |
| Amino Acids | 177 aa |
| UniProt ID | Q9NZH6 |
| NCBI Gene ID | 6053 |
| Ensembl ID | ENSG00000143248 |
| OMIM | 607073 |
| GeneCards | RGS5 |
| Human Protein Atlas | RGS5 |
| Interactions | PDGFRB, PENK, SST, INFLAMMATION, EPILEPSY, CRH |
| KG Connections | 21 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RGS5["<b>RGS5</b>"]
Inflammation{"Inflammation"}
RGS5 -->|"activates"| Inflammation
INFLAMMATION["INFLAMMATION"]
RGS5 -->|"activates"| INFLAMMATION
PDGFRB["PDGFRB"]
RGS5 -->|"activates"| PDGFRB
neurodegeneration["neurodegeneration"]
RGS5 -->|"implicated in"| neurodegeneration
COL1A1["COL1A1"]
COL1A1 -->|"associated with"| RGS5
style RGS5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Inflammation | activates | disease | 0.65 |
| Epilepsy | inhibits | disease | 0.65 |
| PDGFRB | activates | gene | 0.60 |
| PENK | inhibits | gene | 0.60 |
| PVALB | expressed_in | gene | 0.60 |
| SST | inhibits | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| Neuron | inhibits | cell_type | 0.60 |
| Astrocyte | associated_with | cell_type | 0.60 |
| EPILEPSY | inhibits | gene | 0.60 |
| Albumin | associated_with | protein | 0.60 |
| App | associated_with | protein | 0.60 |
| pericytes | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||