Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Rett Syndrome: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| neural stem cells | affects | cell_type | 0.90 |
| neurons | affects | cell_type | 0.80 |
| temporal lobe | affects | brain_region | 0.70 |
| microglia | affects | cell_type | 0.70 |
| striatum | affects | brain_region | 0.60 |
| lipid metabolism | involves | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MICROBIOTA | implicated_in | biological_process | 0.80 |
| MECP2 | causes | gene | 0.70 |
| BDNF | associated_with | protein | 0.70 |
| BDNF | inhibits | gene | 0.70 |
| HDAC3 | regulates | gene | 0.60 |
| BDNF | activates | gene | 0.60 |
| ketamine | treats | compound | 0.60 |
| AADC | treats | gene | 0.60 |
| CREB1 | activates | gene | 0.60 |
| CREB1 | inhibits | gene | 0.60 |
| BDNF | regulates | gene | 0.60 |
| BDNF | phosphorylates | gene | 0.60 |
| BDNF | modulates | gene | 0.60 |
| BDNF | expressed_in | gene | 0.60 |
| HTT | expressed_in | gene | 0.60 |
| BDNF | transported_by | gene | 0.60 |
| HTT | transported_by | gene | 0.60 |
| HTT | inhibits | gene | 0.60 |
| HTT | phosphorylates | gene | 0.60 |
| NGF | associated_with | gene | 0.60 |
| ACSL4 | associated_with | gene | 0.60 |
| HCN1 | associated_with | gene | 0.60 |
| ALS | associated_with | gene | 0.60 |
| CREB | activates | gene | 0.60 |
| CREB | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||