gene

NGF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NGF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1044Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

Summary

Nerve Growth Factor - founding member of neurotrophin family for neuronal survival

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🧬 Gene Info

Gene Symbol	NGF
Full Name	Nerve Growth Factor
Chromosome	1p13.1
Protein Family	Neurotrophin family
Primary Expression	Primarily in nociceptive sensory neurons, cholinergic basal forebrain neurons, sympathetic ganglia
Molecular Weight	30 kDa
Amino Acids	120 aa
Exons	3
Pathways	PI3K, MAPK
UniProt ID	P01138
NCBI Gene ID	4800
Ensembl ID	ENSG00000111665
OMIM	162030
GeneCards	NGF
Human Protein Atlas	NGF
Associated Diseases	ALS, ANGIOGENESIS, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	aducanumab, lecanemab, metformin
Interactions	CHR2, BDNF, GAIN, DCX, HES1, NESTIN
KG Connections	799 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NGF — AlphaFold P01138 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NGF["NGF"]
    NGF -->|"downregulates"| PRDM4["PRDM4"]
    NGF -->|"activates"| Als["Als"]
    NGF -->|"expressed in"| Ischemia["Ischemia"]
    NGF -->|"activates"| Ms["Ms"]
    NGF -->|"regulates"| Inflammation["Inflammation"]
    NGF -->|"target for"| Diabetes["Diabetes"]
    NGF -->|"target for"| Neurodegeneration["Neurodegeneration"]
    CHAT["CHAT"] -->|"regulates"| NGF
    TRKA["TRKA"] -->|"interacts"| NGF
    NRP1["NRP1"] -->|"activates"| NGF
    BDNF["BDNF"] -->|"activates"| NGF
    CHR2["CHR2"] -->|"regulates"| NGF
    GFAP["GFAP"] -->|"activates"| NGF
    TNF["TNF"] -->|"regulates"| NGF
    SLC7A11["SLC7A11"] -->|"activates"| NGF
    GAIN["GAIN"] -->|"activates"| NGF
    GPX4["GPX4"] -->|"activates"| NGF

Outgoing (575)

Target	Relation	Type	Str
NEUROTROPHINS	component_of	protein	0.95
Neurodegeneration	activates	disease	0.95
Nervous System Development	regulates	process	0.90
neurons	expressed_in	cell_type	0.90
Neurite Outgrowth	promotes	phenotype	0.85
neurotrophin signaling	participates_in	pathway	0.85
dorsal root ganglia	expressed_in	cell_type	0.85
ERK	activates	protein	0.85
hippocampus	expressed_in	brain_region	0.80
neurons	activates	cell_type	0.80
Als	activates	disease	0.75
Inflammation	activates	disease	0.75
Diabetes	activates	disease	0.75
Als	treats	disease	0.75
Senescence	activates	disease	0.75
Obesity	activates	disease	0.75
Hepatocellular Carcinoma	biomarker_for	disease	0.75
neurodegeneration	associated_with	disease	0.70
Oxidative Stress	activates	pathway	0.70
Lipid Metabolism	activates	pathway	0.70
Alzheimer's disease	interacts_with	disease	0.70
Alzheimer's disease	biomarker_for	disease	0.70
oxidative stress response	participates_in	pathway	0.70
Alzheimer's disease	treats	disease	0.70
neurons	associated_with	cell_type	0.70
PARP1	associated_with	gene	0.65
TAU	associated_with	gene	0.65
Opioid	therapeutic_target	disease	0.65
Chronic Pain	inhibits	disease	0.65
PI3K	targets	gene	0.65
CSF	interacts_with	phenotype	0.65
Ischemia	expressed_in	disease	0.65
Als	regulates	disease	0.65
Ms	activates	disease	0.65
Inflammation	regulates	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Depression	activates	disease	0.65
Dementia	regulates	disease	0.65
Schizophrenia	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Cancer	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	interacts_with	disease	0.65
Bipolar	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65

Incoming (469)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
BDNF	associated_with	gene	0.90
Optogenetic Stimulation	upregulates	mechanism	0.90
ChR2	upregulates	protein	0.85
FB23	upregulates	drug	0.85
NEURODEGENERATION	associated_with	concept	0.82
PARKINSON'S DISEASE	associated_with	disease	0.82
CYTOKINES	activates	gene	0.80
NEURODEGENERATION	activates	gene	0.80
BDNF	activates	gene	0.74
AMYLOID	associated_with	gene	0.74
CHAT	regulates	gene	0.70
BDNF	implicated_in	gene	0.70
BDNF	protects_against	gene	0.70
GDNF	regulates	gene	0.70
AKT	associated_with	gene	0.66
ALS	associated_with	disease	0.66
GDNF	associated_with	gene	0.65
NOREPINEPHRINE	activates	phenotype	0.65
ULK1	activates	gene	0.65
TRKA	interacts_with	gene	0.60
NRP1	activates	gene	0.60
CHR2	regulates	gene	0.60
GFAP	activates	gene	0.60
TNF	regulates	gene	0.60
SLC7A11	activates	gene	0.60
GAIN	activates	gene	0.60
GPX4	activates	gene	0.60
BDNF	co_discussed	gene	0.60
BAX	activates	gene	0.60
BCL2	activates	gene	0.60
TUBB3	activates	gene	0.60
P38	regulates	gene	0.60
PKC	activates	gene	0.60
SIRT3	activates	gene	0.60
TXNRD1	activates	gene	0.60
APP	activates	gene	0.60
TAU	activates	gene	0.60
TRKB	associated_with	gene	0.60
TPH2	activates	gene	0.60
NBN	regulates	gene	0.60
SGK3	regulates	gene	0.60
SLC24A2	activates	gene	0.60
DNAJC2	regulates	gene	0.60
CHMP3	regulates	gene	0.60
PDE4C	activates	gene	0.60
BAG1	regulates	gene	0.60
VTI1B	regulates	gene	0.60
EIF4G1	regulates	gene	0.60
NOX1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.670

Epigenetic clocks and biological aging in neurodegeneration

neurodegeneration | 2026-04-01 | 6 hypotheses Top: 0.469

Neuroinflammation resolution mechanisms and pro-resolving mediators

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.552

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NGF

Understanding Entity Pages

Summary

Wiki Pages (21)

NGF (Redirect)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

CBS/PSP Supplements Guide

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Neuroresilience Mechanisms and Evidence

CBS/PSP Treatment Rankings

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Growth Factor Therapeutics: Investment Landscape Analysis

IGF-1 Signaling Pathway in Neurodegeneration

Pedunculopontine Nucleus Cholinergic Neurons in Neurodegeneration

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NF-kB Signaling Pathway in Neurodegeneration