Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TEMPORAL LOBE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | TEMPORAL LOBE |
| Key Genes/Proteins | ADAM10, TAU, GASDERMIN, WNT, STING |
| Related Diseases | MICROGLIAL ACTIVATION, COGNITIVE DECLINE, NEUROINFLAMMATION, ALZHEIMER |
Knowledge base pages for this entity
graph TD
TEMPORAL_LOBE["TEMPORAL LOBE"]
GASDERMIN["GASDERMIN"] -->|"degrades"| TEMPORAL_LOBE
PYROPTOSIS["PYROPTOSIS"] -->|"degrades"| TEMPORAL_LOBE
AGING["AGING"] -->|"regulates"| TEMPORAL_LOBE
AMYLOID["AMYLOID"] -->|"regulates"| TEMPORAL_LOBE
STING["STING"] -->|"regulates"| TEMPORAL_LOBE
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"expressed in"| TEMPORAL_LOBE
NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"] -->|"expressed in"| TEMPORAL_LOBE| Target | Relation | Type | Str |
|---|---|---|---|
| ADAM10 | causes | gene | 0.70 |
| ADAM10 | activates | gene | 0.70 |
| TAU | phosphorylates | protein | 0.65 |
| AMYGDALA | interacts_with | brain_region | 0.65 |
| COGNITIVE DECLINE | causes | phenotype | 0.65 |
| WNT | expressed_in | gene | 0.60 |
| ADAM10 | stabilizes | gene | 0.60 |
| PHAGOCYTOSIS | associated_with | phenotype | 0.50 |
| CHOLESTEROL | associated_with | phenotype | 0.50 |
| MICROGLIA | associated_with | cell_type | 0.50 |
| CYTOKINES | associated_with | phenotype | 0.50 |
| CYP46A1 | associated_with | gene | 0.50 |
| NEURONS | associated_with | cell_type | 0.50 |
| EXOSOME | associated_with | organelle | 0.50 |
| CX3CR1 | associated_with | gene | 0.50 |
| TDP-43 | associated_with | gene | 0.50 |
| ADAM10 | associated_with | gene | 0.50 |
| TREM2 | associated_with | gene | 0.50 |
| CD33 | associated_with | gene | 0.50 |
| TFEB | associated_with | gene | 0.50 |
| APP | associated_with | gene | 0.50 |
| TNF | associated_with | gene | 0.50 |
| CSF | associated_with | phenotype | 0.50 |
| NLRP3 | associated_with | gene | 0.45 |
| MTOR PATHWAY | associated_with | pathway | 0.45 |
| AMYLOID | associated_with | protein | 0.45 |
| TAU | associated_with | protein | 0.45 |
| NEURON | associated_with | cell_type | 0.45 |
| ASTROCYTES | associated_with | cell_type | 0.45 |
| ASTROCYTE | associated_with | cell_type | 0.45 |
| APOE | associated_with | gene | 0.45 |
| GLUTAMATE | associated_with | phenotype | 0.45 |
| P-TAU | associated_with | protein | 0.45 |
| WNT PATHWAY | associated_with | pathway | 0.45 |
| GLIOSIS | associated_with | phenotype | 0.45 |
| NEUROGENESIS | associated_with | phenotype | 0.45 |
| GFAP | associated_with | gene | 0.45 |
| CLU | associated_with | gene | 0.45 |
| NECROPTOSIS | associated_with | phenotype | 0.45 |
| RIPK1 | associated_with | gene | 0.45 |
| RIPK3 | associated_with | gene | 0.45 |
| MLKL | associated_with | gene | 0.45 |
| APOPTOSIS | associated_with | phenotype | 0.45 |
| CERAMIDE | associated_with | phenotype | 0.45 |
| UBIQUITIN | associated_with | protein | 0.45 |
| CD68 | associated_with | gene | 0.45 |
| ASTROGLIOSIS | associated_with | phenotype | 0.45 |
| STROKE | associated_with | disease | 0.45 |
| WHITE MATTER | co_discussed | brain_region | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MICROGLIAL ACTIVATION | exacerbates | phenotype | 0.70 |
| GASDERMIN | degrades | gene | 0.65 |
| CORTEX | activates | brain_region | 0.65 |
| NEUROINFLAMMATION | activates | phenotype | 0.65 |
| HIPPOCAMPUS | activates | brain_region | 0.65 |
| HIPPOCAMPUS | causes | brain_region | 0.65 |
| STING | regulates | gene | 0.60 |
| ALZHEIMER | treats | disease | 0.60 |
| ALZHEIMER'S | treats | disease | 0.60 |
| ALZHEIMER'S DISEASE | treats | disease | 0.60 |
| NEURON | contributes_to | cell_type | 0.60 |
| ACHE | treats | gene | 0.60 |
| APOE | causes | gene | 0.60 |
| ASTROCYTE | causes | cell_type | 0.60 |
| ASTROCYTES | causes | cell_type | 0.60 |
| LEWY BODY | regulates | disease | 0.60 |
| CORTEX | participates_in | brain_region | 0.55 |
| APOE4 | associated_with | gene | 0.50 |
| Hippocampus | associated_with | entity | 0.50 |
| AUTISM | associated_with | disease | 0.50 |
| DEPRESSION | associated_with | disease | 0.50 |
| EPILEPSY | associated_with | gene | 0.50 |
| Neurodegeneration | associated_with | disease | 0.50 |
| SCHIZOPHRENIA | associated_with | disease | 0.50 |
| ALZHEIMER | associated_with | gene | 0.50 |
| PARKINSON | associated_with | gene | 0.50 |
| DEMENTIA | associated_with | gene | 0.50 |
| amyotrophic lateral sclerosis | associated_with | gene | 0.50 |
| Alzheimer'S Disease | associated_with | disease | 0.50 |
| HUNTINGTON | associated_with | gene | 0.50 |
| Parkinson's Disease | associated_with | disease | 0.50 |
| MULTIPLE SCLEROSIS | associated_with | disease | 0.50 |
| disease | associated_with | disease | 0.50 |
| ALZHEIMER'S | associated_with | concept | 0.50 |
| FTLD | associated_with | concept | 0.50 |
| PARKINSON'S | associated_with | concept | 0.50 |
| HUNTINGTON'S | associated_with | concept | 0.50 |
| mTOR | associated_with | entity | 0.50 |
| EPILEPSY | regulates | gene | 0.50 |
| tau-pet | activates | disease | 0.50 |
| AMYLOID | activates | gene | 0.50 |
| GSDMD | regulates | protein | 0.50 |
| GASDERMIN D | regulates | protein | 0.50 |
| NLRP3 | regulates | protein | 0.50 |
| Pyroptosis | regulates | pathway | 0.50 |
| Nlrp3 Inflammasome | regulates | pathway | 0.50 |
| GASDERMIN | regulates | gene | 0.50 |
| Proteins | regulates | protein | 0.50 |
| adrenoleukodystrophy | associated_with | disease | 0.50 |
| FRONTOTEMPORAL DEMENTIA | associated_with | disease | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||