Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about neural stem cells: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Cell Type | neural stem cells |
| Also Known As | NSCs, Neural progenitor cells, NPCs, Radial glia |
| Key Pathways | Notch signaling, Wnt/beta-catenin, Sonic Hedgehog (SHH), FGF/EGF receptor signaling, BDNF/TrkB |
| Associated Diseases | Alzheimer's disease (impaired adult neurogenesis), Microcephaly, Glioblastoma (cancer stem cells), Zika virus (NSC destruction) |
| Related Genes | FIP200, TAX1BP1, ATP, MTOR, LAMP1, ACTB |
| Linked Hypotheses | 194 hypotheses |
Knowledge base pages for this entity
graph TD
FIP200["FIP200"] -->|"regulates"| neural_stem_cells["neural stem cells"]
style FIP200 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
TAX1BP1["TAX1BP1"] -->|"regulates"| neural_stem_cells["neural stem cells"]
style TAX1BP1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
ATP["ATP"] -->|"activates"| neural_stem_cells["neural stem cells"]
style ATP fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
MTOR["MTOR"] -->|"activates"| neural_stem_cells["neural stem cells"]
style MTOR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
LAMP1["LAMP1"] -->|"activates"| neural_stem_cells["neural stem cells"]
style LAMP1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
style neural_stem_cells fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| Adult Neurogenesis | involved_in | process | 0.95 |
| Neuronal Markers | associated_with | biomarker | 0.85 |
| Neurological Disorders | treats | disease | 0.82 |
| Tissue Damage | associated_with | phenotype | 0.80 |
| Multiple Sclerosis | treats | disease | 0.80 |
| Inflammation | modulates | process | 0.80 |
| Alzheimer'S Disease | treats | disease | 0.75 |
| Parkinson'S Disease | treats | disease | 0.75 |
| Amyotrophic Lateral Sclerosis | treats | disease | 0.75 |
| SPINAL CORD | associated_with | brain_region | 0.50 |
| WNT PATHWAY | associated_with | pathway | 0.50 |
| DENTATE GYRUS | associated_with | brain_region | 0.50 |
| WNT SIGNALING | associated_with | pathway | 0.50 |
| CURCUMIN | associated_with | drug | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| FIP200 | regulates | protein | 0.90 |
| TAX1BP1 | regulates | protein | 0.90 |
| ATP | activates | gene | 0.90 |
| MTOR | activates | gene | 0.90 |
| LAMP1 | activates | gene | 0.90 |
| ACTB | activates | gene | 0.90 |
| SQSTM1 | activates | gene | 0.90 |
| MAP1LC3B | activates | gene | 0.90 |
| MTORC1 | activates | gene | 0.90 |
| PIK3C3 | activates | gene | 0.90 |
| ATG | activates | gene | 0.90 |
| EGFR | activates | gene | 0.90 |
| CTSD | activates | gene | 0.90 |
| autophagy pathway | active_in | pathway | 0.90 |
| MTOR | regulates | gene | 0.90 |
| RAS | regulates | gene | 0.90 |
| SQSTM1 | regulates | gene | 0.90 |
| MAP1LC3B | regulates | gene | 0.90 |
| MTORC1 | regulates | gene | 0.90 |
| PIK3C3 | regulates | gene | 0.90 |
| ATG | regulates | gene | 0.90 |
| neurodegeneration | affects | disease | 0.90 |
| neuroinflammation | affects | disease | 0.90 |
| Alzheimer's disease | affects | disease | 0.90 |
| RNA | treats | gene | 0.90 |
| RNA | inhibits | gene | 0.90 |
| DNA | regulates | gene | 0.90 |
| RNA | regulates | gene | 0.90 |
| RNA | modulates | gene | 0.90 |
| ROS | activates | gene | 0.90 |
| LC3B | activates | gene | 0.90 |
| NLRP3 | activates | gene | 0.90 |
| AMPK | activates | gene | 0.90 |
| BECN1 | activates | gene | 0.90 |
| PINK1 | activates | gene | 0.90 |
| DNA | activates | gene | 0.90 |
| LC3 | activates | gene | 0.90 |
| ALS | activates | gene | 0.90 |
| PTEN | activates | gene | 0.90 |
| OPTN | activates | gene | 0.90 |
| Parkinson's disease | affects | disease | 0.90 |
| ALS | affects | disease | 0.90 |
| frontotemporal dementia | affects | disease | 0.90 |
| necroptosis | active_in | pathway | 0.90 |
| ROS | regulates | gene | 0.90 |
| AMPK | regulates | gene | 0.90 |
| BECN1 | regulates | gene | 0.90 |
| LC3 | regulates | gene | 0.90 |
| RNA | interacts_with | gene | 0.90 |
| cGAS-STING | active_in | pathway | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||