gene

SCFD1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCFD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections
0Hypotheses
0Analyses
13Outgoing
4Incoming

Summary

SCFD1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, upregulates. Associated with Aging, Ms. Connected to 16 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info
Gene SymbolSCFD1
Chromosome9q34.3
Functionis a member of the Sec1/Munc18 (SM) protein family that plays essential roles in intracellular vesicle trafficking and membrane fusion events throughout the cell.
Primary Expressionboth excitatory glutamatergic and inhibitory GABAergic neurons - Present in astrocytes and oligodendrocytes - High expression
Molecular Weight41 kDa
Amino Acids372 aa
Exons14
Ensembl IDENSG00000084112
GeneCardsSCFD1
Human Protein AtlasSCFD1
gene = SCFD1name = Sec1 Family Domain Containing 1
ncbi_gene_id = 23256ensembl = ENSG00000084112
Associated DiseasesMs
InteractionsJAK2, KDM5D, EXERCISE, AGING, AMPK
KG Connections17 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

SCFD1

gene · 1061 words

Motor Neuron Disease (MND)

disease · 3843 words

SCFD1 Protein

protein · 619 words

Proteins

index · 296 words

Genes

index · 271 words

Pathway Diagram

graph TD
    SCFD1["<b>SCFD1</b>"]
    TREM2["TREM2"]
    SCFD1 -->|"upregulates"| TREM2
    Aging{"Aging"}
    SCFD1 -->|"interacts with"| Aging
    Ms{"Ms"}
    SCFD1 -->|"associated with"| Ms
    JAK2["JAK2"]
    SCFD1 -->|"interacts with"| JAK2
    AKT["AKT"]
    SCFD1 -->|"associated with"| AKT
    KDM5D["KDM5D"]
    SCFD1 -->|"interacts with"| KDM5D
    APOPTOSIS["APOPTOSIS"]
    SCFD1 -->|"associated with"| APOPTOSIS
    FOXO1["FOXO1"]
    SCFD1 -->|"associated with"| FOXO1
    EXERCISE["EXERCISE"]
    SCFD1 -->|"interacts with"| EXERCISE
    Apoptosis(["Apoptosis"])
    SCFD1 -->|"associated with"| Apoptosis
    Akt(["Akt"])
    SCFD1 -->|"associated with"| Akt
    Immune_Response(["Immune Response"])
    SCFD1 -->|"associated with"| Immune_Response
    OxPC["OxPC"]
    OxPC -->|"causes"| SCFD1
    microglia["microglia"]
    microglia -->|"binds"| SCFD1
    AGING["AGING"]
    AGING -->|"interacts with"| SCFD1
    style SCFD1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (13)

TargetRelationTypeStr
SNARE complex formationmodulatesprocess0.90
TREM2upregulatesgene0.80
Aginginteracts_withdisease0.65
Msassociated_withdisease0.65
JAK2interacts_withgene0.60

Incoming (4)

SourceRelationTypeStr
AMPKphosphorylatesprotein0.95
OxPCcauseschemical0.70
microgliabindscell_type0.70
AGINGinteracts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found