Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SCFD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SCFD1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, upregulates. Associated with Aging, Ms. Connected to 16 entities in the SciDEX knowledge graph.
| Gene Symbol | SCFD1 |
| Chromosome | 9q34.3 |
| Function | is a member of the Sec1/Munc18 (SM) protein family that plays essential roles in intracellular vesicle trafficking and membrane fusion events throughout the cell. |
| Primary Expression | both excitatory glutamatergic and inhibitory GABAergic neurons - Present in astrocytes and oligodendrocytes - High expression |
| Molecular Weight | 41 kDa |
| Amino Acids | 372 aa |
| Exons | 14 |
| Ensembl ID | ENSG00000084112 |
| GeneCards | SCFD1 |
| Human Protein Atlas | SCFD1 |
| gene = SCFD1 | name = Sec1 Family Domain Containing 1 |
| ncbi_gene_id = 23256 | ensembl = ENSG00000084112 |
| Associated Diseases | Ms |
| Interactions | JAK2, KDM5D, EXERCISE, AGING, AMPK |
| KG Connections | 17 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SCFD1["<b>SCFD1</b>"]
TREM2["TREM2"]
SCFD1 -->|"upregulates"| TREM2
Aging{"Aging"}
SCFD1 -->|"interacts with"| Aging
Ms{"Ms"}
SCFD1 -->|"associated with"| Ms
JAK2["JAK2"]
SCFD1 -->|"interacts with"| JAK2
AKT["AKT"]
SCFD1 -->|"associated with"| AKT
KDM5D["KDM5D"]
SCFD1 -->|"interacts with"| KDM5D
APOPTOSIS["APOPTOSIS"]
SCFD1 -->|"associated with"| APOPTOSIS
FOXO1["FOXO1"]
SCFD1 -->|"associated with"| FOXO1
EXERCISE["EXERCISE"]
SCFD1 -->|"interacts with"| EXERCISE
Apoptosis(["Apoptosis"])
SCFD1 -->|"associated with"| Apoptosis
Akt(["Akt"])
SCFD1 -->|"associated with"| Akt
Immune_Response(["Immune Response"])
SCFD1 -->|"associated with"| Immune_Response
OxPC["OxPC"]
OxPC -->|"causes"| SCFD1
microglia["microglia"]
microglia -->|"binds"| SCFD1
AGING["AGING"]
AGING -->|"interacts with"| SCFD1
style SCFD1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| SNARE complex formation | modulates | process | 0.90 |
| TREM2 | upregulates | gene | 0.80 |
| Aging | interacts_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| JAK2 | interacts_with | gene | 0.60 |
| AKT | associated_with | gene | 0.60 |
| KDM5D | interacts_with | gene | 0.60 |
| FOXO1 | associated_with | gene | 0.60 |
| APOPTOSIS | associated_with | gene | 0.60 |
| EXERCISE | interacts_with | gene | 0.60 |
| Apoptosis | associated_with | pathway | 0.60 |
| Akt | associated_with | pathway | 0.60 |
| Immune Response | associated_with | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||