Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SORTILIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SORTILIN |
| Function | Sortilin is a member of the vacuolar protein sorting 10 (VPS10) domain receptor family that functions as a multifunctional sorting receptor involved in intracellular trafficking, protein degradatio... |
| Molecular Weight | 100 kDa |
| Amino Acids | 600 aa |
| Pathways | Neurotrophic Signaling, Synaptic Plasticity |
| GeneCards | SORTILIN |
| Human Protein Atlas | SORTILIN |
| Associated Diseases | Alzheimer'S Disease, disease |
| Interactions | TRANSFERRIN, IGF2R, BDNF |
| KG Connections | 34 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SORTILIN["<b>SORTILIN</b>"]
INSULIN["INSULIN"]
SORTILIN -->|"interacts_with"| INSULIN
SORCS1(["SORCS1"])
SORTILIN -->|"associated_with"| SORCS1
ENDOSOME["ENDOSOME"]
SORTILIN -->|"interacts_with"| ENDOSOME
ALZHEIMER(["ALZHEIMER"])
SORTILIN -->|"associated_with"| ALZHEIMER
Alzheimer_S_Disease{"Alzheimer'S Disease"}
SORTILIN -->|"associated_with"| Alzheimer_S_Disease
disease{"disease"}
SORTILIN -->|"associated_with"| disease
TRANSFERRIN(["TRANSFERRIN"])
TRANSFERRIN -->|"interacts_with"| SORTILIN
IGF2R(["IGF2R"])
IGF2R -->|"interacts_with"| SORTILIN
SORCS2(["SORCS2"])
SORCS2 -->|"associated_with"| SORTILIN
SORCS3(["SORCS3"])
SORCS3 -->|"associated_with"| SORTILIN
style SORTILIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7| Target | Relation | Type | Str |
|---|---|---|---|
| BDNF | regulates | protein | 0.90 |
| Trk Receptors | regulates | protein | 0.88 |
| BDNF | transports | protein | 0.85 |
| Neurotrophic Signaling | modulates | pathway | 0.85 |
| Proneurotrophins | mediates | protein | 0.85 |
| NEURON | expressed_in | cell_type | 0.80 |
| INSULIN | interacts_with | concept | 0.50 |
| SORCS1 | associated_with | protein | 0.50 |
| ENDOSOME | interacts_with | concept | 0.50 |
| ALZHEIMER | associated_with | gene | 0.50 |
| Alzheimer'S Disease | associated_with | disease | 0.50 |
| disease | associated_with | disease | 0.50 |
| ALZHEIMER'S | associated_with | concept | 0.50 |
| SORCS1 | regulates | protein | 0.50 |
| SYNAPSE | regulates | concept | 0.50 |
| ALZHEIMER | causes | gene | 0.50 |
| Alzheimer'S Disease | causes | disease | 0.50 |
| disease | causes | disease | 0.50 |
| ALZHEIMER'S | causes | concept | 0.50 |
| Synaptic Plasticity | inhibits | pathway | 0.50 |
| disease | inhibits | disease | 0.50 |
| NEURONS | inhibits | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TDP-43 | regulates_splicing_of | protein | 0.90 |
| TRANSFERRIN | interacts_with | protein | 0.50 |
| IGF2R | interacts_with | protein | 0.50 |
| SORCS2 | associated_with | gene | 0.50 |
| SORCS3 | associated_with | gene | 0.50 |
| SORCS2 | regulates | gene | 0.50 |
| SORCS3 | regulates | gene | 0.50 |
| SORL1 | regulates | gene | 0.50 |
| BDNF | regulates | gene | 0.50 |
| SORL1 | causes | gene | 0.50 |
| BDNF | inhibits | gene | 0.50 |
| Tdp-43 | inhibits | pathway | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||