gene

SORCS3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SORCS3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

0Analyses

29Outgoing

14Incoming

Summary

Page for SORCS3 Gene

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🧬 Gene Info

Gene Symbol	SORCS3
Full Name	Sortilin-Related VPS10 Domain Containing Receptor 3
Chromosome	10q25.3
Protein Type	Receptor
Function	is a member of the sortilin family of VPS10P domain receptors, a group of type I transmembrane proteins highly expressed in the central nervous system.
Primary Expression	the central nervous system
Molecular Weight	270 kDa
Amino Acids	456 aa
Exons	28
Pathways	Neurogenesis
UniProt ID	Q9Y6I8
NCBI Gene ID	23001
Ensembl ID	ENSG00000146411
OMIM	606285
GeneCards	SORCS3
Human Protein Atlas	SORCS3
Associated Diseases	neurodegeneration
KG Connections	43 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SORCS3 — AlphaFold Q9Y6I8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SORCS3["<b>SORCS3</b>"]
    Alzheimer["Alzheimer"]
    SORCS3 -->|"regulates"| Alzheimer
    Neurodegeneration["Neurodegeneration"]
    SORCS3 -->|"regulates"| Neurodegeneration
    Aging["Aging"]
    SORCS3 -->|"regulates"| Aging
    Parkinson["Parkinson"]
    SORCS3 -->|"regulates"| Parkinson
    Neurogenesis["Neurogenesis"]
    SORCS3 -->|"regulates"| Neurogenesis
    Neuron["Neuron"]
    SORCS3 -->|"regulates"| Neuron
    SYNAPSE["SYNAPSE"]
    SORCS3 -->|"regulates"| SYNAPSE
    AND["AND"]
    SORCS3 -->|"associated with"| AND
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    SORCS3 -->|"regulates"| ALZHEIMER_S_DISEASE
    SORCS2["SORCS2"]
    SORCS3 -->|"associated with"| SORCS2
    ENDOSOME["ENDOSOME"]
    SORCS3 -->|"regulates"| ENDOSOME
    AND["AND"]
    SORCS3 -->|"regulates"| AND
    ENDOSOMES["ENDOSOMES"]
    SORCS3 -->|"regulates"| ENDOSOMES
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    SORCS3 -->|"regulates"| NEURODEGENERATIVE_DISEASES
    SORCS2["SORCS2"]
    SORCS3 -->|"regulates"| SORCS2
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    SORCS3 -->|"regulates"| PARKINSON_S_DISEASE
    SORCS1["SORCS1"]
    SORCS1 -->|"associated with"| SORCS3
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"regulates"| SORCS3
    SORCS2["SORCS2"]
    SORCS2 -->|"associated with"| SORCS3
    SORLA["SORLA"]
    SORLA -->|"associated with"| SORCS3
    SORL1["SORL1"]
    SORL1 -->|"regulates"| SORCS3
    SORCS1["SORCS1"]
    SORCS1 -->|"regulates"| SORCS3
    PARKINSON["PARKINSON"]
    PARKINSON -->|"regulates"| SORCS3
    ENDOSOMES["ENDOSOMES"]
    ENDOSOMES -->|"regulates"| SORCS3
    SORCS2["SORCS2"]
    SORCS2 -->|"regulates"| SORCS3
    BDNF["BDNF"]
    BDNF -->|"regulates"| SORCS3
    AGING["AGING"]
    AGING -->|"regulates"| SORCS3
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"regulates"| SORCS3
    SYNAPSE["SYNAPSE"]
    SYNAPSE -->|"regulates"| SORCS3
    GENES["GENES"]
    GENES -->|"regulates"| SORCS3

Outgoing (29)

Target	Relation	Type	Str
Alzheimer	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Aging	regulates	disease	0.65
Parkinson	regulates	disease	0.65
SORCS2	associated_with	gene	0.60
SORCS2	regulates	gene	0.60
SORLA	associated_with	gene	0.60
BDNF	regulates	gene	0.60
Neurogenesis	regulates	pathway	0.60
Neuron	regulates	cell_type	0.60
SYNAPSE	regulates	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
ENDOSOME	regulates	gene	0.60
AND	regulates	gene	0.60
ENDOSOMES	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
Bdnf	regulates	protein	0.60
ALZHEIMER	transports	gene	0.60
Neurogenesis	transports	pathway	0.60
Neuron	transports	cell_type	0.60
Raf	regulates	protein	0.60
Neuron	expressed_in	cell_type	0.55
SORCS1	associated_with	protein	0.50
SORL1	regulates	gene	0.50
SORCS1	regulates	protein	0.50
SORTILIN	associated_with	protein	0.50
SORTILIN	regulates	protein	0.50

Incoming (14)

Source	Relation	Type	Str
SORCS1	associated_with	gene	0.60
SORCS2	associated_with	gene	0.60
SORLA	associated_with	gene	0.60
SORL1	regulates	gene	0.60
SORCS1	regulates	gene	0.60
SORCS2	regulates	gene	0.60
BDNF	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
ENDOSOMES	regulates	gene	0.60
AGING	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
SYNAPSE	regulates	gene	0.60
GENES	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SORCS3

Understanding Entity Pages

Summary

Wiki Pages (7)

SORCS3 Gene

SORCS2 Gene

SORCS1 Gene

SLC30A10 - Zinc Transporter 10

SORCS3 Protein