Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SORCS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SORCS1 is a protein involved in neurodegeneration research. Key relationships include: implicated in, associated with. Associated with Als, Alzheimer, Bipolar. Connected to 11 entities in the SciDEX knowledge graph.
| Gene Symbol | SORCS1 |
| Full Name | Sortilin-Related VPS10 Domain Containing Receptor 1 |
| Chromosome | 10q25.3 |
| Protein Type | Receptor |
| Function | SORCS1 encodes a member of the sortilin family of VPS10P domain receptors. |
| Primary Expression | the brain that participates in intracellular protein trafficking and signaling |
| Subcellular Localization | **BACE1 interaction** - Affects β-secretase processing of APP |
| Molecular Weight | 116 kDa |
| Amino Acids | 600 aa |
| Pathways | Neurogenesis |
| UniProt ID | Q9Y6J0 |
| NCBI Gene ID | 22998 |
| Ensembl ID | ENSG00000146433 |
| OMIM | 606283 |
| GeneCards | SORCS1 |
| Human Protein Atlas | SORCS1 |
| Associated Diseases | Als, Alzheimer, Bipolar, Coronary Artery Disease, Diabetes |
| KG Connections | 54 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SORCS1["<b>SORCS1</b>"]
Diabetes["Diabetes"]
SORCS1 -->|"implicated in"| Diabetes
Bipolar["Bipolar"]
SORCS1 -->|"implicated in"| Bipolar
Als["Als"]
SORCS1 -->|"implicated in"| Als
Coronary_Artery_Disease["Coronary Artery Disease"]
SORCS1 -->|"implicated in"| Coronary_Artery_Disease
Alzheimer["Alzheimer"]
SORCS1 -->|"implicated in"| Alzheimer
Alzheimer["Alzheimer"]
SORCS1 -->|"regulates"| Alzheimer
Neurodegeneration["Neurodegeneration"]
SORCS1 -->|"regulates"| Neurodegeneration
Aging["Aging"]
SORCS1 -->|"regulates"| Aging
Parkinson["Parkinson"]
SORCS1 -->|"regulates"| Parkinson
ALZHEIMER["ALZHEIMER"]
SORCS1 -->|"implicated in"| ALZHEIMER
AMYLOID["AMYLOID"]
SORCS1 -->|"implicated in"| AMYLOID
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
SORCS1 -->|"implicated in"| ALZHEIMER_S_DISEASE
APP["APP"]
SORCS1 -->|"implicated in"| APP
ALZHEIMER["ALZHEIMER"]
SORCS1 -->|"regulates"| ALZHEIMER
SORCS2["SORCS2"]
SORCS1 -->|"associated with"| SORCS2
SORLA["SORLA"]
SORCS1 -->|"associated with"| SORLA
SORCS3["SORCS3"]
SORCS1 -->|"associated with"| SORCS3
Neurogenesis["Neurogenesis"]
SORCS1 -->|"regulates"| Neurogenesis
Neuron["Neuron"]
SORCS1 -->|"regulates"| Neuron
PARKINSON["PARKINSON"]
SORCS1 -->|"regulates"| PARKINSON
ENDOSOMES["ENDOSOMES"]
SORCS1 -->|"regulates"| ENDOSOMES
SORCS2["SORCS2"]
SORCS1 -->|"regulates"| SORCS2
BDNF["BDNF"]
SORCS1 -->|"regulates"| BDNF
SORCS3["SORCS3"]
SORCS1 -->|"regulates"| SORCS3
SYNAPSE["SYNAPSE"]
SORCS1 -->|"regulates"| SYNAPSE
AND["AND"]
SORCS1 -->|"associated with"| AND
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
SORCS1 -->|"regulates"| ALZHEIMER_S_DISEASE
ENDOSOME["ENDOSOME"]
SORCS1 -->|"regulates"| ENDOSOME
NEURODEGENERATION["NEURODEGENERATION"]
SORCS1 -->|"regulates"| NEURODEGENERATION
SORL1["SORL1"]
SORCS1 -->|"regulates"| SORL1| Target | Relation | Type | Str |
|---|---|---|---|
| Diabetes | implicated_in | disease | 0.65 |
| Bipolar | implicated_in | disease | 0.65 |
| Als | implicated_in | disease | 0.65 |
| Coronary Artery Disease | implicated_in | disease | 0.65 |
| Alzheimer | implicated_in | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| Aging | regulates | disease | 0.65 |
| Parkinson | regulates | disease | 0.65 |
| APP | implicated_in | gene | 0.60 |
| SORCS2 | associated_with | gene | 0.60 |
| SORLA | associated_with | gene | 0.60 |
| SORCS3 | associated_with | gene | 0.60 |
| SORCS2 | regulates | gene | 0.60 |
| BDNF | regulates | gene | 0.60 |
| SORCS3 | regulates | gene | 0.60 |
| SORL1 | regulates | gene | 0.60 |
| ALZHEIMER | implicated_in | gene | 0.60 |
| AMYLOID | implicated_in | gene | 0.60 |
| ALZHEIMER'S DISEASE | implicated_in | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| Neurogenesis | regulates | pathway | 0.60 |
| Neuron | regulates | cell_type | 0.60 |
| PARKINSON | regulates | gene | 0.60 |
| ENDOSOMES | regulates | gene | 0.60 |
| SYNAPSE | regulates | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.60 |
| ENDOSOME | regulates | gene | 0.60 |
| NEURODEGENERATION | regulates | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | regulates | gene | 0.60 |
| PARKINSON'S DISEASE | regulates | gene | 0.60 |
| Bdnf | regulates | protein | 0.60 |
| ALZHEIMER | transports | gene | 0.60 |
| Neurogenesis | transports | pathway | 0.60 |
| Neuron | transports | cell_type | 0.60 |
| Raf | regulates | protein | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SORLA | associated_with | gene | 0.60 |
| SORL1 | regulates | gene | 0.60 |
| BDNF | regulates | gene | 0.60 |
| AGING | regulates | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| ENDOSOMES | regulates | gene | 0.60 |
| PARKINSON | regulates | gene | 0.60 |
| SYNAPSE | regulates | gene | 0.60 |
| SORCS2 | associated_with | gene | 0.50 |
| SORCS3 | associated_with | gene | 0.50 |
| SORCS2 | regulates | gene | 0.50 |
| SORCS3 | regulates | gene | 0.50 |
| SORTILIN | associated_with | protein | 0.50 |
| SORTILIN | regulates | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||