protein

SORCS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SORCS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

54Connections
0Hypotheses
0Analyses
40Outgoing
14Incoming

Summary

SORCS1 is a protein involved in neurodegeneration research. Key relationships include: implicated in, associated with. Associated with Als, Alzheimer, Bipolar. Connected to 11 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolSORCS1
Full NameSortilin-Related VPS10 Domain Containing Receptor 1
Chromosome10q25.3
Protein TypeReceptor
FunctionSORCS1 encodes a member of the sortilin family of VPS10P domain receptors.
Primary Expressionthe brain that participates in intracellular protein trafficking and signaling
Subcellular Localization**BACE1 interaction** - Affects β-secretase processing of APP
Molecular Weight116 kDa
Amino Acids600 aa
PathwaysNeurogenesis
UniProt IDQ9Y6J0
NCBI Gene ID22998
Ensembl IDENSG00000146433
OMIM606283
GeneCardsSORCS1
Human Protein AtlasSORCS1
Associated DiseasesAls, Alzheimer, Bipolar, Coronary Artery Disease, Diabetes
KG Connections54 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: SORCS1 — AlphaFold Q9Y6J0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (10)

Knowledge base pages for this entity

Canonical Page

SORCS1 Gene

gene · 1092 words

SORL1 Gene

gene · 2912 words

SORCS2 Gene

gene · 2710 words

SORCS3 Gene

gene · 2104 words

Retromer Complex

mechanism · 1629 words

SNX6 Protein (Sorting Nexin 6)

protein · 974 words

Pathway Diagram

graph TD
    SORCS1["<b>SORCS1</b>"]
    Diabetes["Diabetes"]
    SORCS1 -->|"implicated in"| Diabetes
    Bipolar["Bipolar"]
    SORCS1 -->|"implicated in"| Bipolar
    Als["Als"]
    SORCS1 -->|"implicated in"| Als
    Coronary_Artery_Disease["Coronary Artery Disease"]
    SORCS1 -->|"implicated in"| Coronary_Artery_Disease
    Alzheimer["Alzheimer"]
    SORCS1 -->|"implicated in"| Alzheimer
    Alzheimer["Alzheimer"]
    SORCS1 -->|"regulates"| Alzheimer
    Neurodegeneration["Neurodegeneration"]
    SORCS1 -->|"regulates"| Neurodegeneration
    Aging["Aging"]
    SORCS1 -->|"regulates"| Aging
    Parkinson["Parkinson"]
    SORCS1 -->|"regulates"| Parkinson
    ALZHEIMER["ALZHEIMER"]
    SORCS1 -->|"implicated in"| ALZHEIMER
    AMYLOID["AMYLOID"]
    SORCS1 -->|"implicated in"| AMYLOID
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    SORCS1 -->|"implicated in"| ALZHEIMER_S_DISEASE
    APP["APP"]
    SORCS1 -->|"implicated in"| APP
    ALZHEIMER["ALZHEIMER"]
    SORCS1 -->|"regulates"| ALZHEIMER
    SORCS2["SORCS2"]
    SORCS1 -->|"associated with"| SORCS2
    SORLA["SORLA"]
    SORCS1 -->|"associated with"| SORLA
    SORCS3["SORCS3"]
    SORCS1 -->|"associated with"| SORCS3
    Neurogenesis["Neurogenesis"]
    SORCS1 -->|"regulates"| Neurogenesis
    Neuron["Neuron"]
    SORCS1 -->|"regulates"| Neuron
    PARKINSON["PARKINSON"]
    SORCS1 -->|"regulates"| PARKINSON
    ENDOSOMES["ENDOSOMES"]
    SORCS1 -->|"regulates"| ENDOSOMES
    SORCS2["SORCS2"]
    SORCS1 -->|"regulates"| SORCS2
    BDNF["BDNF"]
    SORCS1 -->|"regulates"| BDNF
    SORCS3["SORCS3"]
    SORCS1 -->|"regulates"| SORCS3
    SYNAPSE["SYNAPSE"]
    SORCS1 -->|"regulates"| SYNAPSE
    AND["AND"]
    SORCS1 -->|"associated with"| AND
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    SORCS1 -->|"regulates"| ALZHEIMER_S_DISEASE
    ENDOSOME["ENDOSOME"]
    SORCS1 -->|"regulates"| ENDOSOME
    NEURODEGENERATION["NEURODEGENERATION"]
    SORCS1 -->|"regulates"| NEURODEGENERATION
    SORL1["SORL1"]
    SORCS1 -->|"regulates"| SORL1

Outgoing (40)

TargetRelationTypeStr
Diabetesimplicated_indisease0.65
Bipolarimplicated_indisease0.65
Alsimplicated_indisease0.65
Coronary Artery Diseaseimplicated_indisease0.65
Alzheimerimplicated_indisease0.65

Incoming (14)

SourceRelationTypeStr
SORLAassociated_withgene0.60
SORL1regulatesgene0.60
BDNFregulatesgene0.60
AGINGregulatesgene0.60
ALZHEIMERregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found