gene

HTR1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HTR1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections
0Hypotheses
0Analyses
27Outgoing
13Incoming

Summary

HTR1A is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, expressed in. Associated with ALS, Als, Ms. Connected to 15 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolHTR1A
Full Name5-Hydroxytryptamine Receptor 1A
Chromosome5q12.3
FunctionAdenylyl cyclase inhibition: Decreased cAMP production
Primary ExpressionRaphe nuclei, Hippocampus, Cortex, Amygdala
Amino Acids421 aa
Exons1
PathwaysNF-κB
UniProt IDP08908
NCBI Gene ID3350
Ensembl IDENSG00000178394
GeneCardsHTR1A
Human Protein AtlasHTR1A
Associated DiseasesALS
Known Drugs/CompoundsD-limonene
InteractionsCRH, CIRCADIAN RHYTHM, AND, GABA
KG Connections40 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: HTR1A — AlphaFold P08908 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

HTR1A Gene

gene · 1030 words

Serotonin Signaling Pathway in Neurodegeneration

mechanism · 2600 words

Otsuka Pharmaceutical

company · 2507 words

SLC6A4 Gene — Serotonin Transporter

gene · 1892 words

Peduncular Ponto-Tegmental Nucleus Neurons

cell · 1582 words

Fast-Spiking Parvalbumin Interneurons

cell · 1505 words

Pathway Diagram

graph TD
    HTR1A["<b>HTR1A</b>"]
    Ms{"Ms"}
    HTR1A -->|"activates"| Ms
    Als{"Als"}
    HTR1A -->|"activates"| Als
    HTR1A -->|"regulates"| Als
    ALS{"ALS"}
    HTR1A -->|"activates"| ALS
    Circadian_Rhythm(["Circadian Rhythm"])
    HTR1A -->|"activates"| Circadian_Rhythm
    CRH["CRH"]
    HTR1A -->|"activates"| CRH
    CIRCADIAN_RHYTHM["CIRCADIAN RHYTHM"]
    HTR1A -->|"activates"| CIRCADIAN_RHYTHM
    AND["AND"]
    HTR1A -->|"activates"| AND
    Hypothalamus["Hypothalamus"]
    HTR1A -->|"expressed in"| Hypothalamus
    Thalamus["Thalamus"]
    HTR1A -->|"expressed in"| Thalamus
    neurodegeneration["neurodegeneration"]
    HTR1A -->|"implicated in"| neurodegeneration
    CRH -->|"activates"| HTR1A
    CRH -->|"regulates"| HTR1A
    CIRCADIAN_RHYTHM -->|"activates"| HTR1A
    style HTR1A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (27)

TargetRelationTypeStr
ds-83b31ef18d49provides_data_fordataset1.00
Insomniatherapeutic_targetdisease0.85
mitophagyregulatesprocess0.85
Sepsis-Associated Encephalopathymodulatesdisease0.80
Msactivatesdisease0.65

Incoming (13)

SourceRelationTypeStr
ds-83b31ef18d49data_indataset1.00
D-limonenetargetscompound0.75
CRHactivatesgene0.60
CRHregulatesgene0.60
GABRA1targetsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found