Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HTR1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
HTR1A is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, expressed in. Associated with ALS, Als, Ms. Connected to 15 entities in the SciDEX knowledge graph.
| Gene Symbol | HTR1A |
| Full Name | 5-Hydroxytryptamine Receptor 1A |
| Chromosome | 5q12.3 |
| Function | Adenylyl cyclase inhibition: Decreased cAMP production |
| Primary Expression | Raphe nuclei, Hippocampus, Cortex, Amygdala |
| Amino Acids | 421 aa |
| Exons | 1 |
| Pathways | NF-κB |
| UniProt ID | P08908 |
| NCBI Gene ID | 3350 |
| Ensembl ID | ENSG00000178394 |
| GeneCards | HTR1A |
| Human Protein Atlas | HTR1A |
| Associated Diseases | ALS |
| Known Drugs/Compounds | D-limonene |
| Interactions | CRH, CIRCADIAN RHYTHM, AND, GABA |
| KG Connections | 40 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
HTR1A["<b>HTR1A</b>"]
Ms{"Ms"}
HTR1A -->|"activates"| Ms
Als{"Als"}
HTR1A -->|"activates"| Als
HTR1A -->|"regulates"| Als
ALS{"ALS"}
HTR1A -->|"activates"| ALS
Circadian_Rhythm(["Circadian Rhythm"])
HTR1A -->|"activates"| Circadian_Rhythm
CRH["CRH"]
HTR1A -->|"activates"| CRH
CIRCADIAN_RHYTHM["CIRCADIAN RHYTHM"]
HTR1A -->|"activates"| CIRCADIAN_RHYTHM
AND["AND"]
HTR1A -->|"activates"| AND
Hypothalamus["Hypothalamus"]
HTR1A -->|"expressed in"| Hypothalamus
Thalamus["Thalamus"]
HTR1A -->|"expressed in"| Thalamus
neurodegeneration["neurodegeneration"]
HTR1A -->|"implicated in"| neurodegeneration
CRH -->|"activates"| HTR1A
CRH -->|"regulates"| HTR1A
CIRCADIAN_RHYTHM -->|"activates"| HTR1A
style HTR1A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Insomnia | therapeutic_target | disease | 0.85 |
| mitophagy | regulates | process | 0.85 |
| Sepsis-Associated Encephalopathy | modulates | disease | 0.80 |
| Ms | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| HYPOTHALAMUS | increases | brain_region | 0.65 |
| THALAMUS | increases | brain_region | 0.65 |
| CRH | activates | gene | 0.60 |
| thalamus | expressed_in | brain_region | 0.60 |
| MTNR1A | targets | gene | 0.60 |
| MTNR1B | targets | gene | 0.60 |
| Circadian Rhythm | activates | pathway | 0.60 |
| CIRCADIAN RHYTHM | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| GABA | activates | gene | 0.60 |
| ALS | associated_with | disease | 0.60 |
| Hypothalamus | expressed_in | brain_region | 0.55 |
| Thalamus | expressed_in | brain_region | 0.55 |
| IL6 | co_expressed_with | gene | 0.50 |
| MTNR1A | co_expressed_with | gene | 0.50 |
| HYPOTHALAMUS | activates | concept | 0.50 |
| HYPOTHALAMUS | co_discussed | brain_region | 0.40 |
| THALAMUS | co_discussed | brain_region | 0.40 |
| benchmark_ot_ad_answer_key:HTR1A | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| D-limonene | targets | compound | 0.75 |
| CRH | activates | gene | 0.60 |
| CRH | regulates | gene | 0.60 |
| GABRA1 | targets | gene | 0.60 |
| GABRB2 | targets | gene | 0.60 |
| CIRCADIAN RHYTHM | activates | gene | 0.60 |
| GABA | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| GABRA1 | co_expressed_with | gene | 0.50 |
| GABRB2 | co_expressed_with | protein | 0.50 |
| HYPOTHALAMUS | associated_with | brain_region | 0.45 |
| benchmark_ot_ad_answer_key:HTR1A | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||