Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TET3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TET3 (Tet Methylcytosine Dioxygenase 3): brain-enriched TET enzyme catalyzing DNA demethylation, essential for neuronal activity-dependent gene expression, learning, memory, and implicated in Alzheimer's disease, Parkinson's disease, and neurodevelopmental disorders.
| Gene Symbol | TET3 |
| Full Name | Tet Methylcytosine Dioxygenase 3 |
| Chromosome | 2p13.1 |
| Protein Family | TET family (Fe(II) and 2-oxoglutarate-dependent dioxygenases) |
| Function | catalyzing DNA demethylation |
| Primary Expression | neurons throughout the brain: - Cerebral cortex: Pyramidal neurons in layers 2-6 - Hippocampus: CA1, CA3, and dentate gyrus granule cells - |
| Amino Acids | 298 aa |
| UniProt ID | Q8IU60 |
| NCBI Gene ID | 200316 |
| Ensembl ID | ENSG00000196950 |
| OMIM | 617555 |
| GeneCards | TET3 |
| Human Protein Atlas | TET3 |
| Length | 2,298 amino acids |
| Approach | Status |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | BMAL1, OCT4, TET1, TET2, STING, DNA |
| KG Connections | 18 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
TET3["<b>TET3</b>"]
Als{"Als"}
TET3 -->|"regulates"| Als
Ms{"Ms"}
TET3 -->|"regulates"| Ms
GENES["GENES"]
TET3 -->|"regulates"| GENES
Epigenetic(["Epigenetic"])
TET3 -->|"inhibits"| Epigenetic
neurodegeneration["neurodegeneration"]
TET3 -->|"implicated in"| neurodegeneration
CLOCK["CLOCK"]
CLOCK -->|"regulates"| TET3
BMAL1["BMAL1"]
BMAL1 -->|"inhibits"| TET3
style TET3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| GENES | regulates | gene | 0.60 |
| Epigenetic | inhibits | pathway | 0.60 |
| epigenetic regulation | participates_in | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CLOCK | regulates | gene | 0.60 |
| BMAL1 | inhibits | gene | 0.60 |
| DNMT3A | regulates | gene | 0.60 |
| MECP2 | regulates | gene | 0.60 |
| STING | activates | gene | 0.60 |
| OCT4 | activates | gene | 0.55 |
| TET1 | activates | gene | 0.55 |
| TET2 | activates | gene | 0.55 |
| TET1 | associated_with | gene | 0.55 |
| TET2 | associated_with | gene | 0.55 |
| DNA | activates | gene | 0.55 |
| DNA | associated_with | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||