gene

TET3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TET3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

0Hypotheses

0Analyses

6Outgoing

12Incoming

0Experiments

0Debates

Summary

TET3 (Tet Methylcytosine Dioxygenase 3): brain-enriched TET enzyme catalyzing DNA demethylation, essential for neuronal activity-dependent gene expression, learning, memory, and implicated in Alzheimer's disease, Parkinson's disease, and neurodevelopmental disorders.

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🧬 Gene Info

Gene Symbol	TET3
Full Name	Tet Methylcytosine Dioxygenase 3
Chromosome	2p13.1
Protein Family	TET family (Fe(II) and 2-oxoglutarate-dependent dioxygenases)
Function	catalyzing DNA demethylation
Primary Expression	neurons throughout the brain: - Cerebral cortex: Pyramidal neurons in layers 2-6 - Hippocampus: CA1, CA3, and dentate gyrus granule cells -
Amino Acids	298 aa
UniProt ID	Q8IU60
NCBI Gene ID	200316
Ensembl ID	ENSG00000196950
OMIM	617555
GeneCards	TET3
Human Protein Atlas	TET3
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	BMAL1, DNA, OCT4, STING, TET1, TET2
KG Connections	18 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TET3 — AlphaFold Q8IU60 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TET3 Gene

gene · 1532 words

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Pathway Diagram

graph TD
    TET3["TET3"]
    Als{"Als"}
    TET3 -->|"regulates"| Als
    Ms{"Ms"}
    TET3 -->|"regulates"| Ms
    GENES["GENES"]
    TET3 -->|"regulates"| GENES
    Epigenetic(["Epigenetic"])
    TET3 -->|"inhibits"| Epigenetic
    neurodegeneration["neurodegeneration"]
    TET3 -->|"implicated in"| neurodegeneration
    CLOCK["CLOCK"]
    CLOCK -->|"regulates"| TET3
    BMAL1["BMAL1"]
    BMAL1 -->|"inhibits"| TET3
    style TET3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
GENES	regulates	gene	0.60
Epigenetic	inhibits	pathway	0.60
epigenetic regulation	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.55

Incoming (12)

Source	Relation	Type	Str
STING	activates	gene	0.60
CLOCK	regulates	gene	0.60
BMAL1	inhibits	gene	0.60
DNMT3A	regulates	gene	0.60
MECP2	regulates	gene	0.60
OCT4	activates	gene	0.55
TET1	activates	gene	0.55
TET2	activates	gene	0.55
TET1	associated_with	gene	0.55
TET2	associated_with	gene	0.55
DNA	activates	gene	0.55
DNA	associated_with	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TET3 in their description or question text

No additional research found