Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TLR8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TLR8 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, activates, implicated in. Associated with Inflammation, Ms. Connected to 10 entities in the SciDEX knowledge graph.
| Gene Symbol | TLR8 |
| Full Name | Toll-Like Receptor 8 |
| Chromosome | Xp22.2 |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | myeloid cells and recognizes single-stranded RNA (ssRNA) from viruses as well as synthetic antiviral compounds |
| Molecular Weight | 110 kDa |
| Amino Acids | 200 aa |
| Pathways | MAPK |
| UniProt ID | [Q9NYK5](https://www.uniprot.org/uniprot/Q9NYK5) |
| Ensembl ID | ENSG00000101916 |
| OMIM | 300366 |
| GeneCards | TLR8 |
| Human Protein Atlas | TLR8 |
| Leucine-rich repeat (LRR) domain | Consists of 25 LRR motifs that form the ligand-binding region |
| Associated Diseases | Ms |
| Interactions | TLR9, TLR3, INFLAMMATION, LIPOPHAGY, MTOR, RAB7A |
| KG Connections | 20 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TLR8["<b>TLR8</b>"]
Ms{"Ms"}
TLR8 -->|"inhibits"| Ms
Inflammation{"Inflammation"}
TLR8 -->|"inhibits"| Inflammation
INFLAMMATION["INFLAMMATION"]
TLR8 -->|"inhibits"| INFLAMMATION
LIPOPHAGY["LIPOPHAGY"]
TLR8 -->|"inhibits"| LIPOPHAGY
Lipid_Metabolism(["Lipid Metabolism"])
TLR8 -->|"inhibits"| Lipid_Metabolism
Toll_Like_Receptor(["Toll-Like Receptor"])
TLR8 -->|"activates"| Toll_Like_Receptor
Mtor(["Mtor"])
TLR8 -->|"activates"| Mtor
neurodegeneration["neurodegeneration"]
TLR8 -->|"implicated in"| neurodegeneration
MTOR["MTOR"]
MTOR -->|"activates"| TLR8
RAB7A["RAB7A"]
RAB7A -->|"activates"| TLR8
style TLR8 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | inhibits | disease | 0.65 |
| Inflammation | inhibits | disease | 0.65 |
| Ms | causes | disease | 0.65 |
| TLR9 | activates | gene | 0.60 |
| TLR3 | activates | gene | 0.60 |
| INFLAMMATION | inhibits | gene | 0.60 |
| LIPOPHAGY | inhibits | gene | 0.60 |
| Lipid Metabolism | inhibits | pathway | 0.60 |
| Toll-Like Receptor | activates | pathway | 0.60 |
| Mtor | activates | pathway | 0.60 |
| Toll-Like Receptor | associated_with | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||