gene 1,533 words KG: TLR8 2026-03-24
kind:genesection:genesstate:published
Contents

TLR8 Gene

🧬 Gene Info
Gene SymbolTLR8
Full NameToll-Like Receptor 8
ChromosomeXp22.2
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionmyeloid cells and recognizes single-stranded RNA (ssRNA) from viruses as well as synthetic antiviral compounds
Molecular Weight110 kDa
Amino Acids200 aa
PathwaysMAPK
UniProt ID[Q9NYK5](https://www.uniprot.org/uniprot/Q9NYK5)
Ensembl IDENSG00000101916
OMIM300366
GeneCardsTLR8
Human Protein AtlasTLR8
Leucine-rich repeat (LRR) domainConsists of 25 LRR motifs that form the ligand-binding region
Associated DiseasesMs
InteractionsTLR9, TLR3, INFLAMMATION, LIPOPHAGY, MTOR, RAB7A
KG Connections20 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Microbial Inflammasome Priming Prevention
Score: 0.58
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.44
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.43

Related Analyses (5)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (10)

TLR Signaling Pathway in Neurodegeneration
mechanism · KG edge: activates
Lipophagy Pathway in Neurodegeneration
mechanism · KG edge: inhibits
TLR9 — Toll-Like Receptor 9
gene · KG edge: activates
TLR7 Gene
gene · KG edge: activates
TLR3 — Toll-Like Receptor 3
gene · KG edge: activates

Knowledge Graph (12 edges)

TLR8 activates TLR9
TLR8 activates TLR3
TLR8 inhibits INFLAMMATION
TLR8 inhibits LIPOPHAGY
TLR8 inhibits Ms
TLR8 inhibits Inflammation
TLR8 inhibits Lipid Metabolism
TLR8 activates Toll-Like Receptor
TLR8 activates Mtor
TLR8 causes Ms