gene

TLR7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TLR7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

121Connections

0Hypotheses

0Analyses

50Outgoing

38Incoming

Summary

TLR7 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with Als, Autism, Autoimmune. Connected to 87 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TLR7
Full Name	Toll-Like Receptor 7
Chromosome	Xp22.2
Function	TLR7 is a type I transmembrane protein localized primarily in endosomal compartments:
Molecular Weight	120 kDa
Pathways	NF-κB
UniProt ID	Q9NYK5
NCBI Gene ID	51284
Ensembl ID	ENSG00000196664
OMIM	300365
GeneCards	TLR7
Human Protein Atlas	TLR7
Extracellular domain	Leucine-rich repeats (LRRs) for nucleic acid recognition
Transmembrane domain	Single pass membrane protein
TIR domain	Intracellular signaling domain
Associated Diseases	Inflammation, Ms
Interactions	CAT, ACTB, RAC2, CTSD, CDK4, CDKN1A
KG Connections	121 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TLR7 — AlphaFold Q9NYK5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TLR7["TLR7"]
    TLR7 -->|"activates"| Tumor["Tumor"]
    TLR7 -->|"target for"| Diabetes["Diabetes"]
    TLR7 -->|"target for"| Obesity["Obesity"]
    TLR7 -->|"target for"| Als["Als"]
    TLR7 -.biomarker for.-> Ms["Ms"]
    TLR7 -->|"target for"| Metabolic_Syndrome["Metabolic Syndrome"]
    TLR7 -->|"regulates"| Autism["Autism"]
    TLR7 -->|"activates"| Inflammation["Inflammation"]
    GENES["GENES"] -->|"target for"| TLR7
    ERN1["ERN1"] -.biomarker for.-> TLR7
    CD4["CD4"] -->|"interacts"| TLR7
    MAPK3["MAPK3"] -->|"interacts"| TLR7
    ZAP70["ZAP70"] -->|"interacts"| TLR7
    TP53["TP53"] -->|"interacts"| TLR7
    MIRNAS["MIRNAS"] -->|"regulates"| TLR7
    CD19["CD19"] -->|"interacts"| TLR7
    EEF2["EEF2"] -->|"interacts"| TLR7
    CCL5["CCL5"] -->|"interacts"| TLR7

Outgoing (83)

Target	Relation	Type	Str
Inflammation	activates	disease	0.75
INFLAMMATION	activates	gene	0.70
Diabetes	therapeutic_target	disease	0.65
Obesity	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	biomarker_for	disease	0.65
Metabolic Syndrome	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Autism	regulates	disease	0.65
Ms	expressed_in	disease	0.65
Autoimmune	inhibits	disease	0.65
Inflammation	associated_with	disease	0.65
Als	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Sepsis	inhibits	disease	0.65
Ms	causes	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
PPARGC1A	biomarker_for	gene	0.60
MYC	biomarker_for	gene	0.60
SLC11A1	biomarker_for	gene	0.60
CAT	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
RAC2	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
CDK4	interacts_with	gene	0.60
CDKN1A	interacts_with	gene	0.60
LCK	interacts_with	gene	0.60
ERN1	biomarker_for	gene	0.60
CXCL10	activates	gene	0.60
ATG16L1	activates	gene	0.60
CD8	interacts_with	gene	0.60
ATG16L1	associated_with	gene	0.60
AURKA	associated_with	gene	0.60
AKT	regulates	gene	0.60
UBIQUITIN	activates	gene	0.60
TBK1	activates	gene	0.60
TLR9	activates	gene	0.60
MYD88	regulates	gene	0.60
TLR8	activates	gene	0.60
TLR3	activates	gene	0.60
TNF	therapeutic_target	gene	0.60
Ferroptosis	therapeutic_target	pathway	0.60
Mapk	interacts_with	pathway	0.60
FERROPTOSIS	therapeutic_target	gene	0.60
IMMUNE INFILTRATION	expressed_in	gene	0.60
INFLAMMATION	associated_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
Autophagy	interacts_with	pathway	0.60

Incoming (38)

Source	Relation	Type	Str
MYD88	activates	gene	0.70
CYTOKINES	activates	gene	0.70
ERN1	biomarker_for	gene	0.60
CD4	interacts_with	gene	0.60
MAPK3	interacts_with	gene	0.60
ZAP70	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
CD19	interacts_with	gene	0.60
EEF2	interacts_with	gene	0.60
CCL5	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
MYC	biomarker_for	gene	0.60
SLC11A1	biomarker_for	gene	0.60
MMP9	activates	gene	0.60
ISG15	associated_with	gene	0.60
PI3K	regulates	gene	0.60
BRCA1	associated_with	gene	0.60
FAS	regulates	gene	0.60
TLR3	activates	gene	0.60
TLR1	activates	gene	0.60
TLR4	activates	gene	0.60
TNF	activates	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
CEBPB	regulates	gene	0.60
CSF1R	regulates	gene	0.60
CX3CR1	regulates	gene	0.60
GENES	therapeutic_target	gene	0.60
MIRNAS	regulates	gene	0.60
TLR	activates	gene	0.60
MIRNAS	inhibits	gene	0.60
IL-6	activates	gene	0.60
TLR	contributes_to	gene	0.60
RNA	contributes_to	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
DNA	contributes_to	gene	0.60
COMPLEMENT	therapeutic_target	gene	0.60
IFN	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TLR7

Understanding Entity Pages

Summary

Wiki Pages (21)

TLR7 Gene

Therapeutics

RNA-Targeted Therapies in Neurodegeneration

PLD4 (Phospholipase D Family Member 4)

Sex-Specific Mechanisms in Alzheimer's Disease

viral-trigger-parkinsons

Post-Acute Viral Reservoir Hypothesis in Parkinson's Disease

Prion-Infected Neurons

Innate Immune Pattern Recognition in 4R-Tauopathies

Human Endogenous Retroviruses in Neurodegenerative Diseases

P2X7 Receptor Antagonists for Neurodegeneration

TLR Signaling in Parkinson's Disease

TLR Signaling Pathway in Neurodegeneration

SLC11A1

TLR8 Gene

Toll-Like Receptor Signaling in Neurodegeneration

TLR7/8/9 Antagonists for Neurodegeneration

IRF3 Protein

IRF7 Protein